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Komplikationen der Leberzirrhose

Ansprechpartner:

PD Dr. med. A. Zipprich/ Frau PD Dr. med. C. Ripoll 

Schwerpunkte "Komplikationen der Leberzirrhose":

  • Therapie von Frühformen der portosystemischen Enzephalopathie
  • Medikamentöse Beeinflussung der splanchnischen und systemischen Hämodynamik bei portaler Hypertension.
  • Verbesserung der Hämostase- bzw. Frührezidivrate in der medikamentösen und endoskopischen Therapie der akuten Ösophagusvarizenblutung. 
  • Veränderungen des Kreislauf bei Patienten mit Leberzirrhose
    • Untersuchungen zu Prognosemarkern bei Patienten mit kompensierter und dekompensierter Leberzirrhose

 

Publikationen

Ripoll C, Genescà J, Araujo IK, Graupera I, Augustin S, Tejedor M, Cirera I,
Aracil C, Sala M, Hernandez-Guerra M, Llop E, Escorsell A, Catalina MV, Cañete N,
Albillos A, Villanueva C, Abraldes JG, Bañares R, Bosch J. Rebleeding prophylaxis
improves outcomes in patients with hepatocellular carcinoma. A multicenter
case-control study. Hepatology. 2013 Dec;58(6):2079-88

Ripoll C, Lastra P, Rincón D, Catalina V, Bañares R. Comparison of MELD,
HVPG, and their changes to predict clinically relevant endpoints in cirrhosis.
Scand J Gastroenterol. 2012 Feb;47(2):204-11

Ripoll C, Yotti R, Bermejo J, Bañares R. The heart in liver transplantation. 
J Hepatol. 2011 Apr;54(4):810-22

Olmedilla L, Pérez-Peña JM, Ripoll C, Garutti I, de Diego R, Salcedo M,
Jiménez C, Bañares R. Early noninvasive measurement of the indocyanine green
plasma disappearance rate accurately predicts early graft dysfunction and
mortality after deceased donor liver transplantation. Liver Transpl. 2009
Oct;15(10):1247-53

Ripoll C, Groszmann RJ, Garcia-Tsao G, Bosch J, Grace N, Burroughs A, Planas 
R, Escorsell A, Garcia-Pagan JC, Makuch R, Patch D, Matloff DS; Portal
Hypertension Collaborative Group. Hepatic venous pressure gradient predicts
development of hepatocellular carcinoma independently of severity of cirrhosis. J
Hepatol. 2009 May;50(5):923-8

Ripoll C, Catalina MV, Yotti R, Olmedilla L, Pérez-Peña J, Lo Iacono O,
Rincón D, García-Fernández MA, Bermejo J, Bañares R. Cardiac dysfunction during
liver transplantation: incidence and preoperative predictors. Transplantation.
2008 Jun 27;85(12):1766-7

Ripoll C, Groszmann R, Garcia-Tsao G, Grace N, Burroughs A, Planas R,
Escorsell A, Garcia-Pagan JC, Makuch R, Patch D, Matloff DS, Bosch J; Portal
Hypertension Collaborative Group. Hepatic venous pressure gradient predicts
clinical decompensation in patients with compensated cirrhosis. Gastroenterology.
2007 Aug;133(2):481-8

Wiese M, Fischer J, Löbermann M, Göbel U, Grüngreiff K, Güthoff W, Kullig U,
Richter F, Schiefke I, Tenckhoff H, Zipprich A, Berg T, Müller T; for the East
German HCV Study Group. Evaluation of liver disease progression in the German
hepatitis C virus (1b)-contaminated anti-D cohort at 35 years after infection.
Hepatology. 2013 

Bañares R, Nevens F, Larsen FS, Jalan R, Albillos A, Dollinger M, Saliba F,
Sauerbruch T, Klammt S, Ockenga J, Pares A, Wendon J, Brünnler T, Kramer L,
Mathurin P, de la Mata M, Gasbarrini A, Müllhaupt B, Wilmer A, Laleman W, Eefsen 
M, Sen S, Zipprich A, Tenorio T, Pavesi M, Schmidt HH, Mitzner S, Williams R,
Arroyo V; RELIEF study group. Extracorporeal albumin dialysis with the molecular 
adsorbent recirculating system in acute-on-chronic liver failure: the RELIEF
trial. Hepatology. 2013 Mar;57(3):1153-62

Zipprich A, Seufferlein T, Dollinger MM. Subclinical ascites defines an
intermediate stage between compensated and decompensated cirrhosis. Z
Gastroenterol. 2012 Sep;50(9):996-1001

Garcia-Pagán JC, Di Pascoli M, Caca K, Laleman W, Bureau C, Appenrodt B, Luca 
A, Zipprich A, Abraldes JG, Nevens F, Vinel JP, Sauerbruch T, Bosch J. Use of
early-TIPS for high-risk variceal bleeding: results of a post-RCT surveillance
study. J Hepatol. 2013 Jan;58(1):45-50 

Zipprich A, Garcia-Tsao G, Rogowski S, Fleig WE, Seufferlein T, Dollinger MM. 
Prognostic indicators of survival in patients with compensated and decompensated 
cirrhosis. Liver Int. 2012 Oct;32(9):1407-14 

Zipprich A, Winkler M, Seufferlein T, Dollinger MM. Comparison of balloon vs. 
straight catheter for the measurement of portal hypertension. Aliment Pharmacol
Ther. 2010 Dec;32(11-12):1351-6 

Zipprich A, Kuss O, Rogowski S, Kleber G, Lotterer E, Seufferlein T, Fleig
WE, Dollinger MM. Incorporating indocyanin green clearance into the Model for End
Stage Liver Disease (MELD-ICG) improves prognostic accuracy in intermediate to
advanced cirrhosis. Gut. 2010 Jul;59(7):963-8

Zipprich A, Mehal WZ, Ripoll C, Groszmann RJ. A distinct nitric oxide and
adenosine A1 receptor dependent hepatic artery vasodilatatory response in the
CCl-cirrhotic liver. Liver Int. 2010 Aug;30(7):988-94

Sohail MA, Hashmi AZ, Hakim W, Watanabe A, Zipprich A, Groszmann RJ, Dranoff 
JA, Torok NJ, Mehal WZ. Adenosine induces loss of actin stress fibers and
inhibits contraction in hepatic stellate cells via Rho inhibition. Hepatology.
2009 Jan;49(1):185-94

Zipprich A, Loureiro-Silva MR, Jain D, D'Silva I, Groszmann RJ. Nitric oxide 
and vascular remodeling modulate hepatic arterial vascular resistance in the
isolated perfused cirrhotic rat liver. J Hepatol. 2008 Nov;49(5):739-45

Zipprich A, Loureiro-Silva MR, D'Silva I, Groszmann RJ. The role of hepatic
arterial flow on portal venous and hepatic venous wedged pressure in the isolated
perfused CCl4-cirrhotic liver. Am J Physiol Gastrointest Liver Physiol. 2008
Jul;295(1):G197-G202

Zipprich A. Hemodynamics in the isolated cirrhotic liver. J Clin
Gastroenterol. 2007 Nov-Dec;41 Suppl 3:S254-8

Zipprich A, Meiss F, Steudel N, Sziegoleit U, Fleig WE, Kleber G.
13C-Methacetin metabolism in patients with cirrhosis: relation to disease
severity, haemoglobin content and oxygen supply. Aliment Pharmacol Ther. 2003 Jun
15;17(12):1559-62

Zipprich A, Steudel N, Behrmann C, Meiss F, Sziegoleit U, Fleig WE, Kleber G.
Functional significance of hepatic arterial flow reserve in patients with
cirrhosis. Hepatology. 2003 Feb;37(2):385-92


Kleber G, Steudel N, Behrmann C, Zipprich A, Hübner G, Lotterer E, Fleig WE. 
Hepatic arterial flow volume and reserve in patients with cirrhosis: use of
intra-arterial Doppler and adenosine infusion. Gastroenterology. 1999
Apr;116(4):906-14