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Publikationen der letzten 5 Jahre

  • Ebelt H, Geißler I, Ruccius S, Otto V, Hoffmann S, Korth H, Klöckner U, Zhang Y, Li Y, Grossmann C, Rueckschloss U, Gekle M, Stieber J, Frantz S, Werdan K, Müller-Werdan U, Loppnow H. Direct inhibition, but indirect sensitization of pacemaker activity to sympathetic tone by the interaction of endotoxin with HCN-channels. Clin Exp Pharmacol Physiol. 2015 Apr 30 [Epub ahead of print]. [PubMed]
  • Schreier B, Rabe S, Winter S, Ruhs S, Mildenberger S, Schneider B, Sibilia M, Gotthardt M, Kempe S, Mäder K, Grossmann C, Gekle M. Moderate inappropriately high aldosterone/NaCl constellation in mice: cardiovascular effects and the role of cardiovascular epidermal growth factor receptor. Sci Rep. 2014 Dec 11;4:7430. [PubMed]
  • Meinel S, Gekle M, Grossmann C. Mineralocorticoid receptor signaling: Crosstalk with membrane receptors and other modulators. Steroids. 2014 Dec;91C:3-10. [PubMed]
  • Korte S, Sträter AS, Drüppel V, Oberleithner H, Jeggle P, Grossmann C, Fobker M, Nofer JR, Brand E, Kusche-Vihrog K. Feedforward activation of endothelial ENaC by high sodium. FASEB J. 2014 Sept;28(9):4015-25. [PubMed]
  • Schreier B, Gekle M, Grossmann C. Role of epidermal growth factor receptor in vascular structure and function. Curr Opin Nephrol Hypertens. 2014 Mar;23(2):113-21. [PubMed]
  • Klöckner U, Rueckschloss U, Grossmann C, Matzat S, Schumann K, Ebelt H, Müller-Werdan U, Loppnow H, Werdan K, Gekle M. Inhibition of cardiac pacemaker channel hHCN2 depends on intercalation of lipopolysaccharide into channel-containing membrane microdomains. J Physiol. 2014 Mar 15;592(Pt6):1199-211. [PubMed]
  • Gekle M, Bretschneider M, Meinel S, Ruhs S, Grossmann C. Rapid mineralocorticoid receptor trafficking. Steroids. 2014 Mar;81:103-8. [PubMed]
  • Drüppel V, Kusche-Vihrog K, Grossmann C, Gekle M, Kasprzak B, Brand E, Pavenstädt H, Oberleithner H, Kliche K. Long-term application of the aldosterone antagonist spironolactone prevents stiff endothelial cell syndrome. FASEB J. 2013 Sep;27(9):3652-9. [PubMed]
  • Meinel S, Ruhs S, Schumann K, Strätz N, Trenkmann K, Grosse I, Keilwagen J, Gekle M, Grossmann C. Mineralocorticoid Receptor Interaction with SP1 Generates a New Response Element for Gene Expression, Nucleic Acids Research 2013 Sep;41(17):8045-60. [PubMed]
  • Schreier B, Rabe S, Schneider B, Bretschneider M, Rupp S, Ruhs S, Neumann J, Rueckschloss U, Sibilia M, Gotthardt M, Grossmann C, Gekle M. Loss of epidermal growth factor receptor in vascular smooth muscle cells and cardiomyocytes causes arterial hypotension and cardiac hypertrophy. Hypertension. 2013 Feb;61(2):333-40. [PubMed]
  • Ruhs S, Strätz N, Schlör K, Meinel S, Mildenberger S, Rabe S, Gekle M, Grossmann C. Modulation of transcriptional mineralocorticoid receptor activity by nitrosative stress. Free Radic Biol Med. 2012 Jun 26;53(5):1088-1100. [PubMed]
  • Grossmann C, Ruhs, S, Langenbruch, L, Mildenberger, S, Straetz, N, Schumann, K, Gekle, M. Nuclear Shuttling Precedes Dimerization in Mineralocorticoid Receptor Signaling. Chem Biol. 2012 Jun 22;19(6):742-51. [PubMed]
  • Grossmann C, Gekle M. Interaction between mineralocorticoid receptor and epidermal growth factor receptor signaling. Mol Cell Endocrinol. 2012 Mar 24;350(2):235-41. [PubMed]
  • Schwerdt G, Frisch A, Mildenberger S, Hilgenfeld T, Grossmann C, Gekle M. Influence of Aldosterone and Salt or Ouabain in A10 Rat Aorta Smooth Muscle Cells. J Vasc Res. 2012 Mar 15;49(3):231-241. [PubMed]
  • Seiferth A, Ruhs S, Mildenberger S, Gekle M, Grossmann C. The phosphatase calcineurin PP2BAβ mediates part of mineralocorticoid receptor transcriptional activity. FASEB J. 2012 Jun;26(6):2327-37. [PubMed]
  • Klöckner U, Rueckschloss U, Grossmann C, Ebelt H, Müller-Werdan U, Loppnow H, Werdan K, Gekle M. Differential reduction of HCN channel activity by various types of lipopolysaccharide. J Mol Cell Cardiol. 2011 Aug;51(2):226-35. 
    [PubMed]
  • Schreier B, Rabe S, Schneider B, Ruhs S, Grossmann C, Hauptmann S, Blessing M, Neumann J, Gekle M. Aldosterone/NaCl-induced renal and cardiac fibrosis is modulated by TGF-β responsiveness of T cells. Hypertens Res. 2011 May;34(5):623-9. [PubMed]
  • Schreier B, Döhler M, Rabe S, Schneider B, Schwerdt G, Ruhs S, Sibilia M, Gotthardt M, Gekle M, Grossmann C. Consequences of epidermal growth factor receptor (ErbB1) loss for vascular smooth muscle cells from mice with targeted deletion of ErbB1. Arterioscler Thromb Vasc Biol. 2011 Jul;31(7):1643-52. [PubMed]
  • Grossmann C, Ruhs S, Seiferth A, Gekle M. Interaction between mineralocorticoid receptor and cAMP/CREB signaling. Steroids. 2010 Aug-Sep;75(8-9):539-43. [PubMed]
  • Günther S, Baba HA, Hauptmann S, Holzhausen HJ, Grossmann C, Punkt K, Kusche T, Jones LR, Gergs U, Neumann J. Losartan reduces mortality in a genetic model of heart failure. Naunyn Schmiedebergs Arch Pharmacol. 2010 Sep;382(3):265-78. [PubMed]
  • Grossmann C, Wuttke M, Ruhs S, Seiferth A, Mildenberger S, Rabe S, Schwerdt G, Gekle M. Mineralocorticoid receptor inhibits CREB signaling by calcineurin activation. FASEB J. 2010 Jun;24(6):2010-9. [PubMed]
  • Grossmann C, Husse B, Mildenberger S, Schreier B, Schuman K, Gekle M. Colocalization of mineralocorticoid and EGF receptor at the plasma membrane. Biochim Biophys Acta. 2010 May;1803(5):584-90. [PubMed]