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Selected Publications

  • Seifert A and Posern G (2017): 
      Tightly controlled MRTF-A activity regulates epithelial differentiation during formation of mammary acini. 
     Breast Cancer Res. 19(1):68
  • Veß A, Blache U, Leitner L, Kurz ARM, Ehrenpfordt A, Sixt M and Posern G (2017): 
      Dual phenotype of MDA-MB-468 cancer cells reveals mutual regulation of tensin3 and adhesion plasticity. 
     J Cell Sci. 130(13), 2172-2184
  • Kojonazarov B, Novoyatleva T, Boehm M, Happe C, Sibinska Z, Tian X, Sajjad A, Luitel H, Posern G, Evans SM, Grimminger F, Ghofrani HA, Weissmann N, Bogaard HJ, Seeger W and Schermuly RT (2017): 
      p38 MAPK Inhibition Improves Heart Function in Pressure Loaded Right Ventricular Hypertrophy. 
     Am J Respir Cell Mol Biol. doi: 10.1165/rcmb.2016-0374OC
  • Weissbach J, Schikora F, Weber A, Kessels M and Posern G (2016): 
      Myocardin-Related Transcription Factor A activation by competition with WH2 domain proteins for actin binding. 
     Mol Cell Biol. 36(10), 1526-39
  • Hermann MR, Jakobson M, Colo GP, Rognoni E, Jakobson M, Kupatt C, Posern G and Fässler R (2016): 
      Integrins synergize to induce expression of the MRTF-A/SRF target gene ISG15 for promoting cancer cell invasion. 
     J Cell Sci. 129(7), 1391-403
  • Eisenach PA, Schikora F and Posern G (2014): 
      Inhibition of arginyltransferase 1 induces transcriptional activity of myocardin-related transcription factor A (MRTF-A) and promotes directional migration. 
     J Biol Chem. 289(51), 35376-87  
  • Hinkel R, Trenkwalder T, Petersen B, Husada W, Gesenhues F, Lee S, Hannappel E, Bock-Marquette I, Theisen D, Leitner L, Boekstegers P, Cierniewski C, Müller OJ, le Noble F, Adams RH, Weinl C, Nordheim A, Reichart B, Weber C, Olson E, Posern G, Deindl E, Niemann H and Kupatt C (2014): 
      MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2
     Nat Commun. 5, 3970
  • Kokai E, Beck H, Weissbach J, Anrold F, Sinske D, Sebert U, Gaiselmann G, Schmidt V, Walther P, Münch J, Posern G and Knöll B (2013): 
      Analysis of nuclear actin by overexpression of wild-type and actin mutant proteins
     Histochem Cell Biol. 141(2), 123-35
  • Shaposhnikov D, Kuffer C, Storchova Z and Posern G (2013): 
      Myocardin related transcription factors are required for coordinated cell cylce progression
     Cell Cycle. 12(11), 1762-72
  • Novoyatleva T, Schymura Y, Janssen W, Strobl F, Swiercz JM, Patra C, Posern G, Wietelmann A, Zheng TS, Schermuly RT and Engel FB (2013): 
      
    Deletion of Fn14 receptor protects from right heart fibrosis and dysfunction
     
    Basic Res Cardiol. 108(2), 325
  • Blajecka K, Marinov M, Leitner L, Uth K, Posern G and Arcaro A (2012): 
      
    Phosphoinositide 3-kinase C2β regulates RhoA and the actin cytoskeleton through an interaction with Dbl
     
    PLoS One. 7(9), e44945
  • Katsch K, Jill de Jong S, Albrecht JC, Steger J, Genth H, Posern G and Biesinger B (2012): 
      Actin-dependent activation of the serum response factor in T cells by the viral oncoprotein Tip
     Cell Commun Signal. 10(1), 5
  • Shaposhnikov D, Descot A, Schilling J and Posern G (2012)
      
    MRTF regulates expression of Bok and Noxa and is involved in apoptotic signalling
     Cell Cycle. 11(1), 141-150
  • Leitner L, Shaposhnikov D, Mengel A, Descot A, Julien S, Hoffmann R and Posern G (2011): 
      
    MAL/MRTF controls migration of non-invasive cells by upregulation of cytoskeleton-associated proteins
     
    J Cell Sci. 124(24), 4318-4331
  • Liang G, Ahlqvist K, Pannem RR, Posern G and Massoumi R (2011): 
      
    Serum response factor controls CYLD expression via MAPK signaling pathway
     
    PLoS ONE. 6(5), e19613
  • Posern G (2011): 
      Should I stall or should I cycle: an inhibitor for Polo-like Kinase 1 with distinct roles in primary cells
     Cell Cycle. 10(7), 1029-1030
  • Smith-Hicks C, Xiao B, Deng R, Ji Y, Zhao X, Shepherd JD, Posern G, Kuhl D, Huganir RL, Ginty DD, Worley PF and Linden DJ (2010): 
      
    SRF binding to SRE 6.9 in the Arc promoter is essential for LTD in cultured Purkinje cells
     Nat Neurosci. 13(9),1082-1089
  • Busche S, Kremmer E and Posern G (2010): 
      E-cadherin regulates MAL-SRF-mediated transcription in epithelial cells
     J Cell Sci. 123(16), 2803-2809
  • Leitner L, Shaposhnikov D, Descot A, Hoffmann R and Posern G (2010): 
      
    Epithelial Protein Lost in Neoplasm a (Eplin-a) is transcriptionally regulated by G-actin and MAL/MRTF coactivators
     
    Mol Cancer. 9(1), 60
  • Descot A, Hoffmann R, Shaposhnikov D, Reschke M, Ullrich A and Posern G (2009): 
      
    Negative regulation of the EGFR-MAPK cascade by actin-MAL mediated Mig6/Errfi-1 induction
     
    Mol Cell. 35(3), 291-304
  • Stern S, Debre E, Stritt C, Berger J, Posern G and Knoell B (2009): 
      
    A nuclear actin function regulates neuronal motility by SRF dependent gene transcription
     
    J Neurosci. 29(14), 4512-4518 
  • Descot A, Rex-Haffner M, Courtois G, Bluteau D, Menssen A, Mercher T, Bernard O, Treisman R and Posern G (2008): 
      
    OTT-MAL is a deregulated activator of SRF-dependent gene expression
     
    Mol Cell Biol. 28(20), 6171-6181
  • Busche S, Descot A, Julien S, Genth H and Posern G (2008): 
      
    Epithelial cell-cell contacts regulate SRF-mediated transcription via Rac-Actin-MAL signalling
     
    J Cell Sci. 121(7), 1025-1035
  • Muehlich S, Cicha I, Garlichs CD, Krueger B, Posern G and Goppelt-Struebe M (2007): 
      
    Actin-dependent regulation of connective tissue growth factor (CTGF) 
     
    Am J Physiol Cell Physiol. 292(5), C1732-1738
  • Posern G and Treisman R (2006): 
      
    Actin' together: serum response factor, its cofactors and the link to signal transduction
     
    Trends in Cell Biol. 16(11), 588-596
  • Posern G, Miralles F, Guettler S and Treisman R (2004): 
      
    Mutant Actins which stabilise F-Actin use distinct mechanisms to activate the SRF coactivator MAL
     
    EMBO J. 23(20), 3973-3983
  • Miralles F, Posern G, Zaromytidou A and Treisman R (2003): 
      
    Actin dynamics control SRF activity by regulation of its coactivator MAL
     
    Cell. 113(3), 329-342
  • Posern G, Sotiropoulos A and Treisman R (2002): 
      
    Mutant Actins reveal a role for unpolymerised actin in control of transcription by serum response factor
     Mol Biol Cell. 13(12), 4167-4178
  • Schmidt M, Goebeler M, Posern G, Feller SM, Seitz CS, Brocker EB, Rapp UR and Ludwig S (2000): 
      
    Ras-independent activation of the Raf/MEK/ERK pathway upon calcium-induced differentiation of keratinocytes
     
    J Biol Chem. 275(52), 41011-41017
  • Posern G, Rapp UR and Feller SM (2000): 
      
    The Crk signalling pathway contributes to the bombesin-induced activation of the small GTPase Rap1
     
    Oncogene. 19(54), 6361-6368
  • Posern G, Saffrich R, Ansorge W and Feller SM (2000): 
      
    Rapid lamellipodia formation in NGF-induced PC12 cells is dependent on Rac and PI3K activity
     
    J Cell Physiol. 183, 416-424
  • Kardinal C, Konkol B, Schulz S, Posern G, Lin H, Adermann K, Eulitz M, Estrov Z, Talpaz M, Arlinghaus RB and Feller SM (2000): 
      
    Cell-penetrating SH3 domain blocker peptides inhibit proliferation of primary blast cells from CML patients
     FASEB J. 14(11), 1529-1538 
  • Sakkab D, Lewitzky M, Posern G, Schaeper U, Sachs M, Birchmeier W and Feller SM (2000): 
      
    Signaling of Hepatocyte Growth Factor / Scatter Factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL
     
    J Biol Chem. 275(15), 10772-10778
  • Voss J, Posern G, Hannemann JR, Wiedemann LM, Turhan AG, Poirel H, Bernard OA, Adermann K, Kardinal C and Feller SM (2000): 
      
    The leukaemic oncoproteins Bcr-Abl and Tel-Abl(ETV6/Abl) have altered substrate preferences and activate similar intracellular signalling pathways
     
    Oncogene. 19, 1684-1690
  • Posern G, Weber CK, Rapp UR and Feller SM (1998): 
      
    Activity of Rap 1 is regulated by bombesin, cell adhesion and cell density in NIH3T3 fibroblasts
     
    J Biol Chem. 273(38), 24297-24300
  • Posern G, Zheng J, Knudsen B, Kardinal C, Müller K, Voss J, Shishido T, Cowburn D, Cheng G, Wang B, Kruh GD, Burrell S, Jakobson C, Lenz D, Zamborelli T, Adermann K, Hanafusa H and Feller SM (1998): 
      
    Development of highly selective SH3 binding peptides for Crk and CRKL which disrupt Crk complexes with DOCK180, SoS and C3G
     
    Oncogene. 16, 1903-1912
  • Feller SM, Posern G, Voss J, Kardinal C, Sakkab D, Zheng J and Knudsen B (1998): 
      
    Physiological signals and oncogenesis mediated through Crk family adapter proteins
     
    J Cell Physiol. 177, 535-552

 

Direktor:
Prof. Dr. Guido Posern

Abt. Genregulation: 
Leiter:    Guido Posern 
Telefon: (0345) 557-3805 
Email:    
Guido Posern

Hausanschrift:
Institut für Physiologische Chemie
Hollystrasse 1
06114 Halle (Saale)

Sekretariat:
Frau Liebert-Hoang
Telefon: (0345) 557-3812 
Fax:        (0345) 557-3811
Email:    Sekretariat