Evamaria Gonschoreck, MD student

The regulation of selected antigen processing genes by microRNAs

In a variety of human tumors of distinct origin a down-regulation or complete loss of MHC class I surface expression was detected, which was associated with a reduced T cell-mediated lysis and poor prognosis of patients. The underlying molecular mechanisms of MHC class I abnormalities could be caused by the modulation and/or inhibition of the expression of APM components. Previous work often demonstrated a discordant mRNA and protein expression for the antigen processing components ERAP1, TAP1 and TAP2 in human tumors suggesting a posttranscriptional gene regulation of APM components. Therefore, the aim of the project is determine whether APM-specific microRNAs are involved in this process.

Supervisor: Prof. Seliger

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E-mail: eva-online(at)hotmail.de