Mechanisms of post‐transcriptional regulation of plakophilin 1 (PKP1) expression and its role in carcinogenesis
Tina studied Biochemistry at the Martin-Luther-University of Halle-Wittenberg. As a PhD student she investigates the posttranscriptional regulation of p120-cell contact proteins by microRNAs. The members of the p120-catenin subfamily of armadillo proteins are essential for cell-cell contact formation. Besides this function in cell-cell adhesion, they participate in various signaling pathways. Their deregulated expression with up- as well as down-regulation has been connected to cancer and metastasis. Because of this it is important to understand how their expression is controlled at the post-transcriptional level by microRNAs and RNA-binding proteins. For example the RNA-binding protein FMRP associates with and inhibits the translation of the p0071 mRNA. In this way FMRP can regulate the actin cytoskeleton in fibroblasts and neuronal cells via the armadillo protein p0071.
Supervisor: Prof. Hatzfeld