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Multifactorial diseases

  • Founder populations

Hypertension and Type 2 Diabetes

Complex traits are harder to elucidate but highly relevant for public health. The traits we are working at, type 2 diabetes and hypertension, affect more than 10% of the population and are major risk factors for cardiovascular disease, stroke, renal failure, and others.

In a sample of hypertensive patients we performed a linkage scan with 1,100 microsatellite markers and identified one region with genome-wide significance. In that sample, we also performed a genome-wide association study with 500,000 SNPs (500K Affy EA; Collaboration with CGC). An example for a region with association is shown below.

Software Association Database

Software Association Database

Reduced heterogeneity in isolated or founder populations – increased power

We recruit patients also from isolated or founder populations where fewer genetic variants contribute to the gene pool and thus also to the pathogenetically relevant sequence variants.

Founder population

Founder population