Messages from Mutant Desmosomes.
Magin TM, Hatzfeld M.
J Invest Dermatol. 2022 Feb;142(2):272-274. doi: 10.1016/j.jid.2021.08.389. Epub 2021 Nov 17.
PMID: 34799122

Desmosomes as Signaling Hubs in the Regulation of Cell Behavior.
Müller L, Hatzfeld M, Keil R.
Front Cell Dev Biol. 2021 Sep 23;9:745670. doi: 10.3389/fcell.2021.745670. eCollection 2021.
PMID: 34631720

Identification of lymphocyte cell-specific protein-tyrosine kinase (LCK) as a driver for invasion and migration of oral cancer by tumor heterogeneity exploitation.
Weiße J, Rosemann J, Müller L, Kappler M, Eckert AW, Glaß M, Misiak D, Hüttelmaier S, Ballhausen WG, Hatzfeld M, Haemmerle M, Gutschner T.
Mol Cancer. 2021 Jun 11;20(1):88. doi: 10.1186/s12943-021-01384-w.
PMID: 34116687

Plakophilin 3 phosphorylation by ribosomal S6 kinases supports desmosome assembly.
Müller L, Rietscher K, Keil R, Neuholz M, Hatzfeld M.
J Cell Sci. 2020 Apr 16;133(8):jcs238295. doi: 10.1242/jcs.238295.
PMID: 32122945

Alterations of protein expression of phospholamban, ZASP and plakoglobin in human atria in subgroups of seniors.
Gergs U, Mangold W, Langguth F, Hatzfeld M, Hauptmann S, Bushnaq H, Simm A, Silber RE, Neumann J.
Sci Rep. 2019 Apr 4;9(1):5610. doi: 10.1038/s41598-019-42141-w.
PMID: 30948763

Cross-Talk between Hemidesmosomes and Focal Adhesions: A Primer for Wound Healing, Blistering Skin Disease, and Skin Aging.
Hatzfeld M, Magin TM.
J Invest Dermatol. 2019 Sep;139(9):1854-1856. doi: 10.1016/j.jid.2019.04.010.
PMID: 31445572

Plakophilin 1 but not plakophilin 3 regulates desmoglein clustering.
Fuchs M, Foresti M, Radeva MY, Kugelmann D, Keil R, Hatzfeld M, Spindler V, Waschke J, Vielmuth F.
Cell Mol Life Sci. 2019 Sep;76(17):3465-3476. doi: 10.1007/s00018-019-03083-8. Epub 2019 Apr 4.
PMID: 30949721

14-3-3 proteins regulate desmosomal adhesion via plakophilins.
Rietscher K, Keil R, Jordan A, Hatzfeld M.
J Cell Sci. 2018 May 22;131(10):jcs212191. doi: 10.1242/jcs.212191.
PMID: 29678907

Phosphorylation-induced unfolding regulates p19INK4d during the human cell cycle.
Kumar A, Gopalswamy M, Wolf A, Brockwell DJ, Hatzfeld M, Balbach J.
Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):3344-3349. doi: 10.1073/pnas.1719774115. Epub 2018 Mar 12.
PMID: 29531090

Desmosomes and Intermediate Filaments: Their Consequences for Tissue Mechanics.
Hatzfeld M, Keil R, Magin TM.
Cold Spring Harb Perspect Biol. 2017 Jun 1;9(6):a029157. doi: 10.1101/cshperspect.a029157.
PMID: 28096266

The armadillo protein p0071 controls KIF3 motor transport.
Becher A, Eiseler T, Porzner M, Walther P, Keil R, Bobrovich S, Hatzfeld M, Seufferlein T.
J Cell Sci. 2017 Oct 1;130(19):3374-3387. doi: 10.1242/jcs.200170. Epub 2017 Aug 14.
PMID: 28808088

Antagonistic Regulation of Intercellular Cohesion by Plakophilins 1 and 3.
Keil R, Rietscher K, Hatzfeld M.
J Invest Dermatol. 2016 Oct;136(10):2022-2029. doi: 10.1016/j.jid.2016.05.124. Epub 2016 Jun 29.
PMID: 27375112

Growth Retardation, Loss of Desmosomal Adhesion, and Impaired Tight Junction Function Identify a Unique Role of Plakophilin 1 In Vivo.
Rietscher K, Wolf A, Hause G, Rother A, Keil R, Magin TM, Glass M, Niessen CM, Hatzfeld M.
J Invest Dermatol. 2016 Jul;136(7):1471-1478. doi: 10.1016/j.jid.2016.03.021. Epub 2016 Mar 28.
PMID: 27033150

Plakophilins in desmosomal adhesion and signaling.
Hatzfeld M, Wolf A, Keil R.
Cell Commun Adhes. 2014 Feb;21(1):25-42. doi: 10.3109/15419061.2013.876017.
PMID: 24460199

The armadillo protein p0071 is involved in Rab11-dependent recycling.
Keil R, Hatzfeld M.
J Cell Sci. 2014 Jan 1;127(Pt 1):60-71. doi: 10.1242/jcs.132266. Epub 2013 Oct 25.
PMID: 24163434

FMRP regulates actin filament organization via the armadillo protein p0071.
Nolze A, Schneider J, Keil R, Lederer M, Hüttelmaier S, Kessels MM, Qualmann B, Hatzfeld M.
RNA. 2013 Nov;19(11):1483-96. doi: 10.1261/rna.037945.112. Epub 2013 Sep 23.
PMID: 24062571

Insulin signaling via Akt2 switches plakophilin 1 function from stabilizing cell adhesion to promoting cell proliferation.
Wolf A, Rietscher K, Glaß M, Hüttelmaier S, Schutkowski M, Ihling C, Sinz A, Wingenfeld A, Mun A, Hatzfeld M.
J Cell Sci. 2013 Apr 15;126(Pt 8):1832-44. doi: 10.1242/jcs.118992. Epub 2013 Feb 26.
PMID: 23444369

p0071/PKP4, a multifunctional protein coordinating cell adhesion with cytoskeletal organization.
Keil R, Schulz J, Hatzfeld M.
Biol Chem. 2013 Aug;394(8):1005-17. doi: 10.1515/hsz-2013-0114.
PMID: 23640939

Folliculin interacts with p0071 (plakophilin-4) and deficiency is associated with disordered RhoA signalling, epithelial polarization and cytokinesis.
Nahorski MS, Seabra L, Straatman-Iwanowska A, Wingenfeld A, Reiman A, Lu X, Klomp JA, Teh BT, Hatzfeld M, Gissen P, Maher ER.
Hum Mol Genet. 2012 Dec 15;21(24):5268-79. doi: 10.1093/hmg/dds378. Epub 2012 Sep 10.
PMID: 22965878

Keratin function and regulation in tissue homeostasis and pathogenesis.
Roth W, Hatzfeld M, Friedrich M, Thiering S, Magin TM.
Biomol Concepts. 2012 Apr;3(2):161-73. doi: 10.1515/bmc.2011.060.
PMID: 25436530

Targeting the palm: a leap forward toward treatment of keratin disorders.
Roth W, Hatzfeld M, Magin TM.
J Invest Dermatol. 2012 Jun;132(6):1541-2. doi: 10.1038/jid.2012.99.
PMID: 22584502

A nuclear function for plakophilin-1 in the DNA damage response?
Hatzfeld M.
J Invest Dermatol. 2010 Nov;130(11):2538-40. doi: 10.1038/jid.2010.258.
PMID: 20944636

A role of plakophilins in the regulation of translation.
Wolf A, Hatzfeld M.
Cell Cycle. 2010 Aug 1;9(15):2973-8. doi: 10.4161/cc.9.15.12446. Epub 2010 Aug 20.
PMID: 20699665

Plakophilin 1 stimulates translation by promoting eIF4A1 activity.
Wolf A, Krause-Gruszczynska M, Birkenmeier O, Ostareck-Lederer A, Hüttelmaier S, Hatzfeld M.
J Cell Biol. 2010 Feb 22;188(4):463-71. doi: 10.1083/jcb.200908135. Epub 2010 Feb 15.
PMID: 20156963

Affilin molecules selected against the human papillomavirus E7 protein inhibit the proliferation of target cells.
Mirecka EA, Hey T, Fiedler U, Rudolph R, Hatzfeld M.
J Mol Biol. 2009 Jul 24;390(4):710-21. doi: 10.1016/j.jmb.2009.05.027. Epub 2009 May 21.
PMID: 19464299

Targeting of p0071 to the midbody depends on KIF3.
Keil R, Kiessling C, Hatzfeld M.
J Cell Sci. 2009 Apr 15;122(Pt 8):1174-83. doi: 10.1242/jcs.045377.
PMID: 19339549

Beyond regulation of cell adhesion: local control of RhoA at the cleavage furrow by the p0071 catenin.
Keil R, Wolf A, Hüttelmaier S, Hatzfeld M.
Cell Cycle. 2007 Jan 15;6(2):122-7. doi: 10.4161/cc.6.2.3741. Epub 2007 Jan 19.
PMID: 17264675

Plakophilins: Multifunctional proteins or just regulators of desmosomal adhesion?
Hatzfeld M.
Biochim Biophys Acta. 2007 Jan;1773(1):69-77. doi: 10.1016/j.bbamcr.2006.04.009. Epub 2006 May 6.
PMID: 16765467

The armadillo protein p0071 regulates Rho signalling during cytokinesis.
Wolf A, Keil R, Götzl O, Mun A, Schwarze K, Lederer M, Hüttelmaier S, Hatzfeld M.
Nat Cell Biol. 2006 Dec;8(12):1432-40. doi: 10.1038/ncb1504. Epub 2006 Nov 19.
PMID: 17115030

ZBP1 regulates mRNA stability during cellular stress.
Stöhr N, Lederer M, Reinke C, Meyer S, Hatzfeld M, Singer RH, Hüttelmaier S.
J Cell Biol. 2006 Nov 20;175(4):527-34. doi: 10.1083/jcb.200608071. Epub 2006 Nov 13.
PMID: 17101699

The p120 family of cell adhesion molecules.
Hatzfeld M.
Eur J Cell Biol. 2005 Mar;84(2-3):205-14. doi: 10.1016/j.ejcb.2004.12.016.
PMID: 15819401

Emerging functions: diseases and animal models reshape our view of the cytoskeleton.
Magin TM, Reichelt J, Hatzfeld M.
Exp Cell Res. 2004 Nov 15;301(1):91-102. doi: 10.1016/j.yexcr.2004.08.018.
PMID: 15501450

A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells.
Straub BK, Boda J, Kuhn C, Schnoelzer M, Korf U, Kempf T, Spring H, Hatzfeld M, Franke WW.
J Cell Sci. 2003 Dec 15;116(Pt 24):4985-95. doi: 10.1242/jcs.00815.
PMID: 14625392

Defining desmosomal plakophilin-3 interactions.
Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F.
J Cell Biol. 2003 Apr 28;161(2):403-16. doi: 10.1083/jcb.200303036. Epub 2003 Apr 21.
PMID: 12707304

Targeting of p0071 to desmosomes and adherens junctions is mediated by different protein domains.
Hatzfeld M, Green KJ, Sauter H.
J Cell Sci. 2003 Apr 1;116(Pt 7):1219-33. doi: 10.1242/jcs.00275.
PMID: 12615965

The Armadillo family protein p0071 is a VE-cadherin- and desmoplakin-binding protein.
Calkins CC, Hoepner BL, Law CM, Novak MR, Setzer SV, Hatzfeld M, Kowalczyk AP.
J Biol Chem. 2003 Jan 17;278(3):1774-83. doi: 10.1074/jbc.M205693200. Epub 2002 Nov 7.
PMID: 12426320

Interaction between Erbin and a Catenin-related protein in epithelial cells.
Jaulin-Bastard F, Arsanto JP, Le Bivic A, Navarro C, Vély F, Saito H, Marchetto S, Hatzfeld M, Santoni MJ, Birnbaum D, Borg JP.
J Biol Chem. 2002 Jan 25;277(4):2869-75. doi: 10.1074/jbc.M109652200. Epub 2001 Nov 15.
PMID: 11711544

Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling.
Chen X, Bonne S, Hatzfeld M, van Roy F, Green KJ.
J Biol Chem. 2002 Mar 22;277(12):10512-22. doi: 10.1074/jbc.M108765200. Epub 2002 Jan 14.
PMID: 11790773

The mitotic-spindle-associated protein astrin is essential for progression through mitosis.
Gruber J, Harborth J, Schnabel J, Weber K, Hatzfeld M.
J Cell Sci. 2002 Nov 1;115(Pt 21):4053-9. doi: 10.1242/jcs.00088.
PMID: 12356910

Plakophilin 1 interferes with plakoglobin binding to desmoplakin, yet together with plakoglobin promotes clustering of desmosomal plaque complexes at cell-cell borders.
Bornslaeger EA, Godsel LM, Corcoran CM, Park JK, Hatzfeld M, Kowalczyk AP, Green KJ.
J Cell Sci. 2001 Feb;114(Pt 4):727-38. doi: 10.1242/jcs.114.4.727.
PMID: 11171378

The fate of desmosomal proteins in apoptotic cells.
Weiske J, Schöneberg T, Schröder W, Hatzfeld M, Tauber R, Huber O.
J Biol Chem. 2001 Nov 2;276(44):41175-81. doi: 10.1074/jbc.M105769200. Epub 2001 Aug 10.
PMID: 11500511

Expression of secreted frizzled related proteins 3 and 4 in human ventricular myocardium correlates with apoptosis related gene expression.
Schumann H, Holtz J, Zerkowski HR, Hatzfeld M.
Cardiovasc Res. 2000 Feb;45(3):720-8. doi: 10.1016/s0008-6363(99)00376-4.
PMID: 10728394

p0071, a member of the armadillo multigene family, is a constituent of sarcomeric I-bands in human skeletal muscle.
Schröder R, van der Ven PF, Warlo I, Schumann H, Fürst DO, Blümcke I, Schmidt MC, Hatzfeld M.
J Muscle Res Cell Motil. 2000;21(6):577-86. doi: 10.1023/a:1026587530656.
PMID: 11206135

The function of plakophilin 1 in desmosome assembly and actin filament organization.
Hatzfeld M, Haffner C, Schulze K, Vinzens U.
J Cell Biol. 2000 Apr 3;149(1):209-22. doi: 10.1083/jcb.149.1.209.
PMID: 10747098

Molecular map of the desmosomal plaque.
North AJ, Bardsley WG, Hyam J, Bornslaeger EA, Cordingley HC, Trinnaman B, Hatzfeld M, Green KJ, Magee AI, Garrod DR.
J Cell Sci. 1999 Dec;112 ( Pt 23):4325-36. doi: 10.1242/jcs.112.23.4325.
PMID: 10564650

The armadillo family of structural proteins.
Hatzfeld M.
Int Rev Cytol. 1999;186:179-224. doi: 10.1016/s0074-7696(08)61054-2.
PMID: 9770300

The head domain of plakophilin-1 binds to desmoplakin and enhances its recruitment to desmosomes. Implications for cutaneous disease.
Kowalczyk AP, Hatzfeld M, Bornslaeger EA, Kopp DS, Borgwardt JE, Corcoran CM, Settler A, Green KJ.
J Biol Chem. 1999 Jun 25;274(26):18145-8. doi: 10.1074/jbc.274.26.18145.
PMID: 10373410

Protein-protein interactions between keratin polypeptides expressed in the yeast two-hybrid system.
Schnabel J, Weber K, Hatzfeld M.
Biochim Biophys Acta. 1998 Jun 22;1403(2):158-68. doi: 10.1016/s0167-4889(98)00036-6.
PMID: 9630597

Tyrosine phosphorylation and src family kinases control keratinocyte cell-cell adhesion.
Calautti E, Cabodi S, Stein PL, Hatzfeld M, Kedersha N, Paolo Dotto G.
J Cell Biol. 1998 Jun 15;141(6):1449-65. doi: 10.1083/jcb.141.6.1449.
PMID: 9628900