Molecular Mechanism of Maternal to Zygotic Transition in Germ Cells
Tosin Oyewale studied Biochemistry for his Bachelors and Medical Molecular Biology for his Masters degree. He started a PhD in the lab of Christian Eckmann, where he is currently investigating the Maternal to Zygotic Transition (MZT) and its molecular mechanisms in germ cells, using embryonic germ cell development in C. elegans as a model system.
Maternal to zygotic transition allows developmental control to be transferred from maternally controlled gene expression program to zygotic gene expression program. The global silencing of the zygotic genome during the earliest stages of embryogenesis makes post-transcriptional control, by maternally donated factors, the prevalent gene expression program. Major findings have revealed that the timing, scale and the molecular mechanisms of MZT differ in germ cells and the soma. For example, compared to the soma, germ cells experience delayed MZT and hence undergo prolonged maternal control. In his PhD, Tosin aims to elucidate the molecular principles that assist germ cells in establishing prolonged maternal control.
Supervisor: Prof. Christian Eckmann