Expression and function of the non-coding WISP1 transcript (lncWISP1) in fibrosis
Patrick studies medicine at the Martin-Luther-University Halle-Wittenberg. As a MD student he explores the expression and function of the non-coding WISP1 transcript (lncWISP1) in fibrosis.
Wnt1-inducible signaling pathway protein 1 (WISP1) is involved in organ development but also in fibrogenic and cancerous tissue alterations. Recent data showed that an alternative WISP1 transcript is upregulated by different cell stressors in renal cells leading to the increased formation of extracellular matrix (ECM) components such as collagens. In subsequent studies it turned out that this transcript very likely does not code for a protein, hence it is a representative of the new class of long noncoding RNAs which was named lncWISP1 (long noncoding WISP1). We are characterizing the functional interactions of lncWisp, the cellular consequences of lncWISP1 expression, the occurrence of lncWISP1 in healthy and diseased tissues, as well as the half-life of lncWISP1.
Supervisor: Prof. Michael Gekle