VHL- and hypoxia-mediated alterations in the metabolism of renal cell carcinoma
Sandra studied biology at the Martin Luther University Halle-Wittenberg. As a PhD student she investigates the altered metabolism of clear cell renal cell carcinoma.
During the last decade the knowledge about the molecular mechanisms of the cellular and metabolic adaption to hypoxia and the function of the “von Hippel Lindau” (VHL) protein in renal cell carcinoma (RCC) has increased, but there exists little information about the overlap and differences in gene/protein expression of both processes. Therefore the aim of this study was to dissect VHL- and hypoxia-regulated alterations in the metabolism of RCC using ome-based strategies. The effect of the VHL- and hypoxia-regulated altered gene and protein expression pattern on the cellular metabolism was analyzed by determination of glucose uptake, lactate secretion, extracellular pH, lactate dehydrogenase activity, amino acid content and ATP levels.
Supervisor: Prof. Barbara Seliger
Phone: +49-(0)345 557 4445