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Scientists

SP1 - Marcus A. Glomb 
Glycation alters the functionality of proteins during ageing

SP2 - Rüdiger HorstkorteHeidi Olzscha 
Acetylation and glycosylation in protein folding and misfolding: Impact on ageing-related diseases

SP3 - Thorsten Pfirrmann 
The GID-complex as a regulator of cellular energy homeostasis and organismal longevity

SP7 - Anne Navarrete Santos 
Investigation of histone modifications in stem cells from young and old donors: Impact of EZH2 O-GlcNAcylation on stem cell ageing
 
SP8 - Andreas Simm 
Cellular and molecular impact of nuclear protein glycation

SP9 - Lars-Oliver Klotz 
Protein glycation and glutathionylation as modulators of the activity of pro-ageing factors in C. elegans

SP10 - Christian A. Hübner 
Age-dependent changes of the skeletal muscle glycome

SP11 - Claudia Großmann 
Age-dependent impact of nitrosative stress-induced changes of mineralocorticoid receptor signalling 

SP12 - Stefan H. Heinemann 
Visualisation of protein modifications and their impact on the electrical signalling

SP13 - Regine Heller 
AGE modifications in endothelial cells – functional characterisation and relevance for senescence and ageing

SP14 - Otmar Huber 
The role of Nit1 in Wnt/b-catenin – FOXO signalling and ageing

SP15 - Alessandro Ori 
Functional characterisation of AGE modifications in ageing

SP16 - Dan Rujescu 
Glycosylation in Alzheimer-associated proteins in the context of microglia-mediated inflammation and disturbed blood-brain barrier functions

SP17 - Christoph Kaether 
Role of Klotho in brain ageing

SP181 - Julia von Maltzahn 
Molecular differences underlying functional impairment of aged muscle stem cells

SP192 - Steve Hoffmann 
Bioinformatics analysis of transcriptional and epigenomic responses to posttranslational modifications

SP202,3 - Florian MeierDarya Zibrova 
Identification of novel O-GlcNAcylated substrates in endothelial cells and investigation of their role in senescence and ageing

SP212,3 Patricia FranzkaSonnhild MittagChristian Hübner 
The role of GMPPA in the developing and ageing brain 

 

 

1,2,3 These projects are associated with the RTG in the second-generation period (funding sources: JSMM (SP18), FLI (SP19), IZKF (SP20,21)) FLI - Leibniz Institute on Aging- Fritz Lipmann Institute; JSMM - Jena School of Molecular Medicine; IZKF - Interdisciplinary Centre of Clinical Research