Investigating the role of IGF2BP1 in the anaplastic thyroid carcinoma
Jacob studied Biology at the Martin-Luther-University Halle-Wittenberg. In the lab of Prof. Hatzfeld, Medical Faculty/Section Pathobiochemistry, he made efforts on investigating the post-transcriptional regulation of the NPRAP/δ-catenin expression in MCF-7 cells. In 2014 he started his PhD thesis in the lab of Stefan Hüttelmaier. There he further investigates the role of the mRNA-binding protein IGF2BP1 in the anaplastic thyroid carcinoma.
The insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is found to be highly expressed during embryogenesis, but is almost exclusively lost in adult tissues. As a RNA-binding protein it was found to modulate the fate of several targeted transcripts which often encode proteins involved in developmental processes. Previous in vitro and in vivo-studies revealed that IGF2BP1 acts as a post-transcriptional driver of cancer progression as its de novo-synthesis in tumor-derived cells likely causes aggressive malignancy phenotypes. Jacob aims on further investigating the assumed oncogenic role of IGF2BP1 in the anaplastic thyroid carcinoma by focusing on migration, invasion, stemness and survival.