Aktuelle Publikationen aus dem Anatomischen Institut


AG Prof. Kielstein

Oswald J, Büttner M, Jasinski-Bergner S, Jacobs R, Rosenstock P, Kielstein H (2018) Leptin affects filopodia and cofilin in NK-92 cells in a dose- and time-dependent manner. European Journal of Histochemistry 62:2848.


AG Prof. Kielstein

Bähr I, Goritz V, Doberstein H, GGR Hiller, Rosenstock P, Jahn J, Pörtner O, Berreis T, Mueller T, Spielmann J, Kielstein H. (2017) Diet-induced obesity is associated with an impaired NK cell function and an increased colon cancer incidence. J Nutr Metab. 2017:4297025, doi:10.1155/2017/4297025.

Gutteck N, Martin H, Hanke T, Heilmann A, Kielstein H, Gradl G, Richter M, Delank KS, Wohlrab D. (2017) Posterolateral plate fixation with Talarlock® is more stable than screw fixation in ankle arthrodesis in a biomechanical cadaver study. Foot and Ankle Surgery. (in press)

Jasinski-Bergner S, Büttner M, Quandt D, Seliger B, Kielstein H. (2017) Adiponectin and Its Receptors Are Differentially Expressed in Human Tissues and Cell Lines of Distinct Origin. Obes Facts. 10(6):569-583, doi: 10.1159/000481732.

Jasinski-Bergner S, Radetzki A.-L., Jahn J, Wohlrab D, Kielstein H. (2017) Impact of the body mass index on perioperative immunological disturbances in patients with hip and knee arthroplasty. J Orthop Surg Res. 12(1):58. 

Hiller RG, Patecki M, Neunaber C, Reifenrath J, Kielstein JT, Kielstein H. (2017) A comparative study of bone biopsies from the iliac crest, the tibial bone, and the lumbar spine. BMC Nephrol. 18(1):134. doi: 10.1186/s12882-017-0550-5.

Rosenstock P, Horstkorte R, Gnanapragassam VS, Harth J, Kielstein H. (2017) Siglec-7 expression is reduced on a natural killer (NK) cell subset of obese humans. Immunol Res. 65(5): 1017-1024, doi: 10.1007/s12026-017-8942-y.

Spielmann J, Hanke J, Knauf D, Ben-Eliyahu S, Jacobs R, Stangl GI, Bähr I, Kielstein H. (2017) Significantly enhanced lung metastasis and reduced organ NK cell functions in diet-induced obese rats. BMC Obesity 4:24. doi: 10.1186/s40608-017-0161-5.

Yussif A-S, Lassey A, Ganyaglo G Y-k, Kantelhardt EJ, Kielstein H (2017) The long-term effects of adolescent pregnancies in a community in Northern Ghana on subsequent pregnancies and births of the young mothers. Reproductive Health 14:178.

AG Prof. Dehghani

Bazwinsky-Wutschke I, Zipprich A, Dehghani F. Daytime-Dependent Changes of Cannabinoid Receptor Type 1 and Type 2 Expression in Rat Liver. Int J Mol Sci. 2017 18(9). pii: E1844. doi: 10.3390/ijms18091844.

Grabiec U and Dehghani F (2017) N-Arachidonoyl Dopamine: A Novel Endocannabinoid and Endovanilloid with Widespread Physiological and Pharmacological Activities. Cannabis and Cannabinoid Research. 2(1)183-196.

Grabiec U, Hohmann T, Hammer N, Dehghani F. (2017) Organotypic Hippocampal Slice Cultures As a Model to Study Neuroprotection and Invasiveness of Tumor Cells. 
J. Vis. Exp. (126)e55359.

Höch A, Özkurtul O, Pieroh P, Josten C, Böhme J.(2017) Outcome and 2-Year Survival Rate in Elderly Patients With Lateral Compression Fractures of the Pelvis. Geriatr Orthop Surg Rehabil. 8(1):3-9.

Höch A, Pieroh P, Henkelmann R, Josten C, Böhme J. (2017) In-screw polymethylmethacrylate-augmented sacroiliac screw for the treatment of fragility fractures of the pelvis: a prospective, observational study with 1-year follow-up.BMC Surg. 17(1):132. doi: 10.1186/s12893-017-0330-y.

Hohmann T, Grabiec U, Ghadban C, Feese K, Dehghani F. (2017) The Influence of Biomechanical Properties and Cannabinoids on Tumor Invasion. Cell Adh Migr. 11(1):54-67.

Hohmann T, Grabiec U, Vogel C, Ghadban C, Ensminger S, Bache M, Vordermark D, Dehghani F (2017) The Impact of Non-Lethal Single-Dose Radiation on Tumor Invasion and Cytoskeletal Properties. Int. J. Mol. Sci. 18(9), 2001; doi:10.3390/ijms18092001.

Hohmann T, Kessler J, Grabiec U, Bache M, Vordermark D, Dehghani F. (2017) Automatic detection of DNA double strand breaks after irradiation using an γH2AX assay. Histol Histopathol. 15:11945. doi: 10.14670/HH-11-945.

Jafarpour A, Dehghani F, Korf HW. (2017) Identification of an endocannabinoid system in the rat pars tuberalis-a possible interface in the hypothalamic-pituitary-adrenal system? Cell Tissue Res. 368(1)115-123.

Kurz S*, Pieroh P*, Lenk M, Josten C, Böhme J. (2017) Three-dimensional reduction and finite element analysis improves the treatment of pelvic malunion reconstructive surgery. A case report. Medicine 96:42(e8136) *
These authors contributed equally to the article as first authors.

Kurz S, Thieme R, Amberg R, Groth M, Jahnke HG, Pieroh P, Horn LC, Kolb M, Huse K, Platzer M, Volke D, Dehghani F, Buzdin A, Engel K, Robitzki A, Hoffmann R, Gockel I, Birkenmeier G. (2017) The anti-tumorigenic activity of A2M-A lesson from the naked mole-rat. PLoS One. 12(12):e0189514. 

Pieroh P, Wagner DC, Alessandri B, Dabbagh Nazari M, Ehrlich A, Ghadban C, Hobusch C, Birkenmeier G, Dehghani F. (2017) Comparative Examination of Temporal Glyoxalase 1 Variations Following Perforant Pathway Transection, Excitotoxicity, and Controlled Cortical Impact Injury. Neurotox Res. doi: 10.1007/s12640-017-9808-8. [Epub ahead of print]

Pieroh P, Wagner DC, Ghadban C, Birkenmeier G, Dehghani F (2017). Ethyl pyruvate does not require microglia for mediating neuroprotection after excitotoxic injury. CNS Neurosci Ther. 23(10): 798-807, doi: 10.1111/cns.12725.

AG Prof. Fischer/ Forschungsteam Navarrete Santos

Barandalla M, Haucke E, Fischer B, Navarrete Santos Al, Colleoni S, Galli C, Navarrete Santos An, Lazzari G. (2017) Comparative Analysis of AGE and RAGE Levels in Human Somatic and Embryonic Stem Cells under H2O2-Induced Noncytotoxic Oxidative Stress Conditions. Oxidative Medicine and Cellular Longevity. Volume 2017, Article ID 4240136,

Fischer B, Schindler M, Mareike Pendzialek S, Gürke J, Haucke E, Grybel KJ, Thieme R, Navarrete Santos A. (2017) The Long-Term Effect of the Periconception Period on the Embryo's Epigenetic Profile and Phenotype: The Role of Maternal Disease Such as Diabetes and How the Effect Is Mediated (Example from a Rabbit Model). Adv Exp Med Biol. 1014:107-115. doi: 10.1007/978-3-319-62414-3_6.

Pendzialek SM, Schindler M, Plösch T, Gürke J, Haucke E, Hecht S, Fischer B, Navarrete Santos A. (2017) Cholesterol metabolism in rabbit blastocysts under maternal diabetes. Reprod Fertil Dev. 29(10):1921-1931. doi: 10.1071/RD15542. 

Schindler M, Pendzialek M, Grybel KJ, Seeling T, Gürke J, Fischer B, Navarrete Santos A.(2017) Adiponectin stimulates lipid metabolism via AMPK in rabbit blastocysts.Hum Reprod. 32(7): 1382-1392, doi: 10.1093/humrep/dex087.

Seeling T, Čikoš Š, Grybel KJ, Janštová Ž, Pendzialek SM, Schindler M, Špirková A, Navarrete Santos A. (2017) A Diabetic Pregnancy Alters the Expression of Stress-Related Receptors in Gastrulating Rabbit Blastocyst and in the Reproductive Tract. Reprod Sci. 1:19337919117707055, doi: 10.1177/1933719117707055. 

apl. Prof. Claassen

Claassen H, Schicht M, Fleiner B, Hillmann R, Hoogeboom S, Tillmann B, Paulsen F. (2017) Different Patterns of Cartilage Mineralization Analyzed by Comparison of Human, Porcine, and Bovine Laryngeal Cartilages. J Histochem Cytochem. 1:22155417703025. 


AG Prof. Kielstein

Jasinski-Bergner S, Reches A, Stoehr C, Massa C, Gonschorek E, Huettelmaier S, Braun J, Wach S, Wullich B, Spath V, Wang E, Marincola FM, Mandelboim O, Hartmann A, Seliger B. (2016) Identification of novel microRNAs regulating HLA-G expression and investigating their clinical relevance in renal cell carcinoma. Oncotarget. 7(18):26866-78.

Lenz M, Stoffel K, Gueorguiev B, Kielstein H, Hofmann GO. (2016) Enhancing fixation strength in periprosthetic femur fractures by orthogonal plating - a biomechanical study. J Orthop Res. 34(4):591-6.

Lenz M, Stoffel K, Kielstein H, Mayo K, Hofmann GO, Gueorguiev B. (2016) Plate fixation in periprosthetic femur fractures Vancouver type B1—Trochanteric hook plate or subtrochanterical bicortical locking? Injury. 47(12):2800-4.

Mattheis L, Jung J-S, Hiebl B, Garrels W, Kielstein H, Spielmann J. (2016) Perioperative support reduces mortality of obese BALB/c mice after ovariectomy. Lab Animal. 45(7):262-7.

Rothe K, Quandt D, Schubert K, Rossol M, Klingner M, Jasinski-Bergner S, Scholz R, Seliger B, Pierer M, Baerwald C, Wagner U. (2016) Latent Cytomegalovirus Infection in Rheumatoid Arthritis and Increased Frequencies of cytolytic LIR-1+ CD8+ T Cells. Arthritis Rheumatol. 68(2):337-46.

Scheurer J, Stoevesandt D, Siekmann H, Kielstein, H. (2016) The tell-tale thigh. BMJ Case reports. 

Schwimmer-Okike N, Niebuhr J, Schramek GG, Frantz S, Kielstein H.(2016) The Presence of a Large Chiari Network in a Patient with Atrial Fibrillation and Stroke. Case Rep Cardiol. 2016:4839315.

Seliger B, Jasinski-Bergner S, Quandt D, Stoehr C, Bukur J, Wach S, Legal W, Taubert H, Wullich B, Hartmann A. (2016) HLA-E expression and its clinical relevance in human renal cell carcinoma. Oncotarget. 7(41):67360-72.

Skopp A, May M, Janke J, Kielstein H, Wunder R, Flade-Kuthe R, Kuthe A, Jordan J, Engeli S (2016) Regulation of G0/G1 Switch Gene 2 (G0S2) expression in human adipose tissue. Arch Physiol Biochem. 122(2):47-53.

AG Prof. Dehghani

Bazwinsky-Wutschke I, Härtig W, Kretzschmar R, Rübsamen R. (2016) Differential morphology of the superior olivary complex of Meriones unguiculatus and Monodelphis domestica revealed by calcium-binding proteins. Brain Struct Funct. 221(9):4505-45B.

Birkenmeier G, Hemdan NY, Kurz S, Bigl M, Pieroh P, Debebe T, Buchold M, Thieme R, Wichmann G, Dehghani F. (2016) Ethyl Pyruvate Combats Human Leukemia Cells but Spares Normal Blood Cells. PLoS One. 11(8):e0161571.

Ernst J, Grabiec U, Greither T, Fischer B, Dehghani F. (2016) The endocannabinoid system in the human granulosa cell line KGN. Mol Cell Endocrinol. 423:67-76.

Höch A, Pieroh P, Dehghani F, Josten C, Böhme J (2016) An Atraumatic Symphysiolysis with a Unilateral Injured Sacroiliac Joint in a Patient with Cushing's Disease: A Loss of Pelvic Stability Related to Ligamentous Insufficiency? Case Rep Orthop. 2016:9250938.

Pieroh P, Schneider S, Lingslebe U, Sichting F, Wolfskämpf T, Josten C, Böhme J, Hammer N, Steinke H. (2016) The Stress-Strain Data of the Hip Capsule Ligaments Are Gender and Side Independent Suggesting a Smaller Contribution to Passive Stiffness. PLoS One. 11(9):e0163306.

Pieroh P, Spindler N, Langer S, Josten C, Böhme J (2016) A double-barrelled fibula graft restoring pelvic stability after late posterior ring instability related to a surgical treated osteitis pubis: a case report. Arch Orthop Trauma Surg. 136(1):47-53.

Theopold J, Pieroh P, Scharge ML, Marquaß B, Hohmann T, Josten C, Hepp P. (2016) Improved accuracy of K-wire positioning into the glenoid vault by intraoperative 3D image intensifier-based navigation for the glenoid component in shoulder arthoplasty. Orthop Traumatol Surg Res. pii: S1877-0568(16)30016-0.

Zhao M, Altankov G, Grabiec U, Bennett M, Salmeron-Sanchez M, Dehghani F, Groth T. (2016) Molecular composition of GAG-collagen I multilayers affects remodeling of terminal layers and osteogenic differentiation of adipose-derived stem cells. Acta Biomater. 41:86-99.

AG Prof. Fischer/ Forschungsteam Navarrete Santos

Ernst J, Grabiec U, Greither T, Fischer B, Dehghani F. (2016) The endocannabinoid system in the human granulosa cell line KGN. Mol Cell Endocrinol. 423:67-76.

Fiandanese N, Borromeo V, Berrini A, Fischer B, Schaedlich K, Schmidt J-S, Secchi C, Pocar P. (2016) Maternal exposure to a mixture of di(2-ethylhexyl) phthalate (DEHP) and polychlorinated biphenyls (PCBs) causes reproductive dysfunction in adult male mouse offspring. Reprod Toxicol. 65:123-132.

Guerke J, Schindler M, Pendzialek M, Thieme R, Grybel KJ, Heller R, Spengler K, Fleming T, Fischer B, Navarrete Santos A. (2016) Maternal diabetes promotes mTORC1 downstream signalling in rabbit preimplantation embryos. Reproduction. 151(5):465-76.

Pendzialek SM, Schindler M, Plösch T, Gürke J, Haucke E, Hecht S, Fischer B, Navarrete Santos A. (2016) Cholesterol metabolism in rabbit blastocysts under maternal diabetes. Reproduction, Fertility and Development (accepted for publication)

apl. Prof. Claassen

Claassen, H., Schmitt, O., Wree, A., Schulze, M. (2016): Variations in brachial plexus with respect to concomitant accompanying aberrant arm arteries. Ann Anat 208: 40-48.


AG Prof. Kielstein

Jahn J, Spielau M, Brandsch C, Stangl GI, Delank K-S, Bähr I, Berreis T, Wrann CD, Kielstein H. (2015) Decreased NK cell functions in obesity can be re-activated by fat mass reduction. Obesity. 23(11):2233-41.

Jasinski-Bergner S, Stoehr C, Bukur J, Massa C, Braun J, Huettelmaier S, Spath V, Wartenberg R, Legal W, Taubert H, Wach S, Wullich B, Hartmann A, Seliger B. (2015) Clinical relevance of miR-mediated HLA-G regulation and the associated immune cell infiltration in renal cell carcinoma. Oncoimmunology. 4(6):e1008805.

Kielstein H, Suntharalingam M, Perthel R, Song R, Schneider S, Martens-Lobenhoffer J, Jäger K, Bode-Böger SM, Kielstein JT. (2015) Role of the endogenous nitric oxide inhibitor ADMA and BDNF in depression and behavioral changes– clinical and preclinical data in chronic kidney disease. Nephrol Dial Transplant. 30(10):1699-705.

Laue T, Wrann CD, Hoffmann-Castendiek B, Pietsch D, Hübner L, Kielstein H. (2015) Altered NK cell function in obese healthy humans. BMC Obesity. 2:1.

Schmidt JJ, Jahn J, Golla P, Hafer C, Kielstein JT, Kielstein H. (2015) Effect of therapeutic plasma exchange on plasma levels and total removal of adipokines and inflammatory markers. BMC Obesity. 2:37.

Schneider SM, Malecki AK, Muller K, Schonfeld R, Girndt M, Mohr P, Hiss M, Kielstein H, Jager K, Kielstein JT. (2015) Effect of a single dialysis session on cognitive function in CKD5D patients: a prospective clinical study. Nephrology Dialysis Transplantation. 30(9):1551-9.

Waschke A, Berger-Roscher N, Kielstein H, Ewald C, Kalff R, Wilke HJ. (2015) Cement Augmented Anterior Odontoid Screw Fixation is Biomechanically Advantageous in Osteoporotic Patients with Anderson Type II Fractures. J Spinal Disord Tech. 28(3):E126-32.

AG Prof. Dehghani

Kanawade R, Lengenfelder B, Menezes TM, Hohmann M, Kopfinger S, Hohmann T, Grabiec U, Klämpfl F, Menezes Gonzales J, Waldner M, Schmidt M (2015) Improved cancer diagnostics by different image processing techniques on OCT images  Proc. SPIE 9541, Optical Coherence Imaging Techniques and Imaging in Scattering Media, 95410J (July 9, 2015); doi: 10.1117/12.2183838

Koch M, Ferreirós N, Geisslinger G, Dehghani F, Korf HW. (2015) Rhythmic control of endocannabinoids in the rat pineal gland. Chronobiol Int. 32(6):869-74. 

AG Prof. Fischer

Gürke J, Hirche F, Thieme R, Haucke E, Schindler M, Stangl G, Fischer B, Navarrete Santos A. (2015) Maternal diabetes leads to adaptation in embryonic amino acid metabolism during early pregnancy. PLOS ONE. 10(5):e0127465.

Klöting N, Hesselbarth N, Gericke M, Kunath A, Biemann R, Chakaroun R, Kosacka J, Kovacs P, Kern M, Stumvoll M, Fischer B, Rolle-Kampczyk U, Feltens R, Otto W, Wissenbach DK, von Bergen M, Blüher M. (2015) Di-(2-Ethylhexyl)-Phthalate (DEHP) Causes Impaired Adipocyte Function and Alters Serum Metabolites. PLoS One. 10(12):e0143190.

Schaedlich K, Schmidt JS, Kwong WY, Sinclair KD, Kurz R, Jahnke HG, Fischer B. (2015) Impact of di-ethylhexylphthalate (DEHP) exposure on metabolic programming in P19-ECC derived cardiomyocytes. J Appl Toxicol. 35:861-869.

apl. Prof. Claassen

Beileke S, Claassen H, Wagner W, Matthies C, Ruf C, Hartmann A, Garreis F, Paulsen F, Schicht M, Bräuer L. (2015) Expression and Localization of Lung Surfactant Proteins in Human Testis. PLoS One. 10(11):e0143058.

Prof. Peschke

Peschke E, Bähr I, Mühlbauer E. (2015) Experimental and clinical aspects of melatonin and clock genes in diabetes. J Pineal Res. 59(1):1-23.

Zibolka J, Mühlbauer E, Peschke E. (2015) Melatonin influences somatostatin secretion from human pancreatic δ-cells via MT1 and MT2 receptors. J Pineal Res. 58(2):198-209.


AG Prof. Kielstein

Fischer MJ, Stephan M, Kielstein H, Rahne H, Nugraha B, Gutenbrunner C, Ro JY, Svensson P. (2014) Functions of the temporomandibular system in extracranial chronic pain conditions: modulatory effects on nocifensive behavior in an animal model. J Manip Physiol Ther. 37:485-593.

Friedrich LH, Jungebluth P, Sjöqvist S, Lundin V, Haag JC, Lemon G, Gustafsson Y, Ajalloueian F, Sotnichenko A, Kielstein H, Burguillos MA, Joseph B, Teixeira AI, Lim ML, Macchiarini P. (2014) Preservation of aortic root architecture and properties using a detergent-enzymatic perfusion protocol. Biomaterials. 35:1907-13.

Schmidt JJ, Hafer C, Spielmann J, Hadem J, Schönenberger E, Schmidt BMW, Kielstein JT. (2014) Removal characteristics and total dialysate content of glutamine and other amino acids in critically ill patients with acute kidney injury undergoing extended dialysis. Nephron Clin Pract. 126:62-6.

AG Prof. Dehghani

Herzfeld E, Strauss C, Simmermacher S, Bork K, Horstkorte R, Dehghani F, Scheller C. (2014) Investigation of the neuroprotective impact of nimodipine on Neuro2a cells by means of a surgery-like stress model. Int J Mol Sci. 15:18453-65.

Pieroh P, Birkenmeier G, Dehghani F. (2014) The temporal and spatial dynamics of glyoxalase I following excitoxicity and brain ischaemia. Biochem Soc T. 42:534-7.

Pieroh P, Koch M, Wagner DC, Boltze J, Ehrlich A, Ghadban C, Hobusch C, Birkenmeier G, Dehghani F. (2014) Temporal dynamics of glyoxalase 1 in secondary neuronal injury. PLoS One. 9:e87364.

Weis S, Schlaich TC, Dehghani F, Carvalho T, Sommerer I, Fricke S, Kahlenberg F, Mössner J, Hoffmeister A. (2014) p8 Deficiency causes siderosis in spleens and lymphocyte apoptosis in acute pancreatitis. Pancreas. 43:1277-85.

AG Prof. Fischer

Biemann R, Fischer B, Blüher M, Navarrete Santos A. (2014) Tributyltin affects adipogenic cell fate commitment in mesenchymal stem cells by a PPARgamma independent mechanism. Chem-Biol Interact. 214:1-9.

Biemann R, Fischer B, Navarrete Santos A. (2014) Adipogenic Effects of a Combination of the Endocrine-Disrupting Compounds Bisphenol A, Diethylhexylphthalate, and Tributyltin. Obesity Facts. 7:48-56.

Ernst J, Jann JC, Biemann R, Koch HM, Fischer B. (2014) Effects of the environmental contaminants DEHP and TCDD on estradiol synthesis and aryl hydrocarbon receptor and peroxisome proliferator-activated receptor signalling in the human granulosa cell line KGN. Mol Hum Reprod. 20:919-28.

Haucke E, Navarrete Santos Al, Simm A, Henning C, Glomb M, Guerke J, Schindler M, Fischer B, Navarrete Santos An. (2014) Accumulation of advanced glycation end products in the rabbit blastocyst under maternal diabetes. Reproduction. 148:169-78.

Haucke E, Navarrete Santos Al, Simm A, Silber R-E, Hofmann B. (2014) Glycation of extracellular matrix proteins impairs migration of immune cells. Wound Repair Regen. 22:239–45.

Ott C, Jacobs K, Haucke E, Navarrete Santos A, Grune T, Simm A. (2014) Role of advanced glycation end products in cellular signaling. Redox Biol. 2:411-29.

Schindler M, Pendzialek M, Navarrete Santos Al, Plösch T, Seyring S, Gürke J, Haucke E, Knelangen JM, Fischer B and Navarrete Santos An. (2014) Maternal diabetes leads to unphysiological high lipid accumulation in rabbit preimplantation embryos. Endocrinology. 155:1498-1509.

apl. Prof. Claassen

Claassen H, Schicht M, Sel S, Paulsen F. (2014) Special pattern of endochondral ossification in human laryngeal cartilages: X-ray and light-microscopic studies on thyroid cartilage. Clin Anat. 27:423-30.

Schicht M, Ernst J, Nielitz A, Fester L, Tsokos M, Guddat SS, Bräuer L, Bechmann J, Delank KS, Wohlrab D, Paulsen F, Claassen H. (2014) Articular cartilage chondrocytes express aromatase and use enzymes involved in estrogen metabolism. Arthritis Res Ther. 16:R93.

Prof. Peschke

Bazwinsky-Wutschke I, Bieseke L, Mühlbauer E, Peschke E. (2014) Influence of melatonin receptor signalling on parameters involved in blood glucose regulation. J Pineal Res. 56:82-96.

Bazwinsky-Wutschke I, Mühlbauer E, Albrecht E, Peschke E. (2014) Calcium-signaling components in rat insulinoma β-cells (INS-1) and pancreatic islets are differentially influenced by melatonin. J Pineal Res. 56:439-49.

Klemenz A, Wolgast S, Hanitzsch R, Markwardt F, Peschke E. (2014) Effects of insulin on norepinephrine- and acetylcholine-induced membrane currents of pinealocytes from healthy Wistar and type 2 diabetic GK rats. Cell Tissue Res. 355:437-46.


AG Prof. Kielstein

Beutel G, Perthel R, Suntharalingam M, Bode-Böger SM, Martens-Lobenhoffer J, Kielstein JT, Kielstein H. (2013) Effect of chronic elevated asymmetric dimethylarginine (ADMA) levels on granulopoiesis. Ann Hematol. 92(4):505-8.

Brunkhorst L, Kielstein H (2013) Comparison of anthropometric characteristics in professional triathletes and cyclists. Biol Sport. 30:269-73.

Huebner L, Engeli S, Wrann CD, Goudeva L, Laue T, Kielstein H. (2013) Human NK cell subset functions are differentially affected by adipokines. PLoS One. 8(9): e75703.

Jäger K, Kielstein H, Dunse M, Nass N, Paulsen F, Sel S. (2013) Enzymes of urea synthesis are expressed at the ocular surface, and decreased urea in the tear fluid is associated with dry-eye syndrome. Graefes Arch Clin Exp Ophthalmol. 251(8):1995-2002.

Jäger K, Wolf S, Dobrowolny H, Steiner J, Nave H, Maronde E, Bogerts B, Bernstein HG. (2013) Differential topochemistry of three cationic amino acid transporter proteins, hCAT1, hCAT2 and hCAT3, in the adult human brain. Amino Acids. 44(2):423-33.

Nugraha B, Korallus C, Kielstein H, Gutenbrunner C. (2013) CD3+CD56+ Natural Killer T cells in fibromyalgia syndrome patients: relation to anxiety and depression. Clin Exp Rheumatol. 31:9-15.

Peschke E, Bähr I, Mühlbauer E. (2013) Melatonin and Pancreatic Islets: Interrelationships between Melatonin, Insulin and Glucagon. Int J Mol Sci. 14:6981-7015.

Poppendieck S, Kapapa M, Haas P, Kielstein H. (2013) Prolonged postsurgical recovery period and adverse effects of a leptin application in endotoxemic obese rodents. Life Sci. 93(5-6):247-56.

Schramek GGR, Stoevesandt D, Reising A, Kielstein JT, Hiss M, Kielstein H (2013) Imaging in anatomy: a comparison of imaging techniques in embalmed human cadavers. BMC Medical Education. 13(1):143.

AG Prof. Dehghani

Benz AH, Renné C, Maronde E, Koch M, Grabiec U, Kallendrusch S, Rengstl B, Newrzela S, Hartmann S, Hansmann ML, Dehghani F. (2013) Expression and functional relevance of cannabinoid receptor 1 in Hodgkin lymphoma. PLoS One. 8(12):e81675.

Chuang HN, Lohaus R, Hanisch UK, Binder C, Dehghani F, Pukrop T. (2013) Coculture system with an organotypic brain slice and 3D spheroid of carcinoma cells. J Vis Exp. Oct 9; (80) doi: 10.3791/50881

Chuang HN, van Rossum D, Sieger D, Siam L, Klemm F, Bleckmann A, Bayerlová M, Farhat K, Scheffel J, Schulz M, Dehghani F, Stadelmann C, Hanisch UK, Binder C, Pukrop T. (2013) Carcinoma cells misuse the host tissue damage response to invade the brain. Glia. 61(8):1331-46.

Dimitrova K, Stoehr M, Dehghani F, Dietz A, Wichmann G, Bertolini J, Mozet C. (2013) Overexpression of the Hedgehog signalling pathway in head and neck squamous cell carcinoma. Onkologie. 36(5):279-286.

Hagemann C, Fuchs S, Monoranu CM, Herrmann P, Smith J, Hohmann T, Grabiec U, Kessler AF, Dehghani F, Löhr M, Ernestus RI, Vince GH, Stein U. (2013) Impact of MACC1 on human malignant glioma progression and patients' unfavorable prognosis. Neuro Oncol. 15(12):1696-709.

Kallendrusch S, Kremzow S, Nowicki M, Grabiec U, Winkelmann R, Benz A, Kraft R, Bechmann I, Dehghani F, Koch M. (2013) The G protein-coupled receptor 55 (GPR55) ligand L-α-lysophosphatidylinositol (LPI) exerts microglia-dependent neuroprotection after excitotoxic lesion. Glia. 61:1822-31.

Merz F, Gaunitz F, Dehghani F, Renner C, Meixensberger J, Gutenberg A, Giese A, Schopow K, Hellwig C, Schäfer M, Bauer M, Stöcker H, Taucher-Scholz G, Durante M, Bechmann I. (2013) Organotypic slice cultures of human glioblastoma reveal different susceptibilities to treatments. Neuro Oncol. 15(6):670-81.

AG Prof. Fischer

Schindler M, Fischer S, Thieme R, Fischer B, Navarrete Santos A. (2013) cAMP-responsive element binding protein: a vital link in embryonic hormonal adaptation. Endocrinology. 154(6):2208-21.

apl. Prof. Claassen

Claassen H, Schmitt O, Schulze M, Wree A. (2013) Variation in the hypothenar muscles and its impact on ulnar tunnel syndrome. Surg Radiol Anat. 35(10):893-9.

Prof. Peschke

Batulevicius D, Frese T, Peschke E, Pauza DH, Batuleviciene V. (2013) Remodelling of the intracardiac ganglia in diabetic Goto-Kakizaki rats: an anatomical study. Cardiovasc Diabetol. 12:85.

Hofmann K, Schönerstedt U, Mühlbauer E, Wedekind D, Peschke E. (2013) Clock Gene Expression in the Liver of Streptozotocin-induced and Spontaneous Type 1 Diabetic Rats. Horm Metab Res. 45:629-39.

Mühlbauer E*, Bazwinsky-Wutschke I*, Wolgast S, Labucay K, Peschke E. (2013) Differential and day-time dependent expression of nuclear receptors RORα, RORβ, RORγ and RXRα in the rodent pancreas and islet. Mol Cell Endocrinol. 365(2):129-138. *These authors contributed equally to the article as first authors.

Peschke E, Bähr I, Mühlbauer E. (2013) Melatonin and Pancreatic Islets: Interrelationships between Melatonin, Insulin and Glucagon. Int J Mol Sci. 14:6981-7015.


AG Prof. Kielstein

Jungebluth P, Bader A, Baiguera S, Möller S, Jaus M, Lim ML, Fried K, Kjartansdóttir KR, Go T, Nave H, Harringer W, Lundin V, Teixeira AI, Macchiarini P. (2012) The concept of in vivo airway tissue engineering. Biomaterials. 33:4319-26.

Kielstein JT, Suntharalingam M, Perthel R, Rong S, Martens-Lobenhoffer J, Jäger K, Bode-Böger SM, Nave H. (2012) Asymmetric dimethylarginine may mediate increased heat pain threshold in experimental chronic kidney disease. Nephrol Dial Transplant. 27:899-902.

Tzialidou-Palermo I, von Kaisenberg CS, Garcia-Rocha GJ, Schloesser HW, Baehr I, Schippert C. (2012) Diagnostic challenges of hemihematocolpos and dysmenorrhea in adolescents: obstructed hemivagina, didelphys or bicornuate uterus and renal aplasia is a rare female genital malformation. Arch Gynecol Obstet. 286:785-91.

Wrann CD, Eguchi J, Bozec A, Xu Z, Mikkelsen T, Gimble J, Nave H, Wagner EF, Ong SE, Rosen ED. (2012) FOSL2 promotes leptin gene expression in human and mouse adipocytes. J Clin Invest. 122:1010-21.

Wrann CD, Laue T, Hübner L, Kuhlmann S, Jacobs R, Goudeva L, Nave H. (2012) Short-term and long-term leptin exposure differentially affetcs human natural killer cell immune functions. Am J Physiol Endocrinol Metab. 302:E108-16.

AG Prof. Dehghani

Ebrahimi F, Koch M, Pieroh P, Ghadban C, Hobusch C, Bechmann I, Dehghani F. (2012) Time dependent neuroprotection of mycophenolate mofetil: effects on temporal dynamics in glial proliferation, apoptosis, and scar formation. J Neuroinflammation. 9:89.

Grabiec U, Koch M, Kallendrusch S, Kraft R, Hill K, Merkwitz C, Ghadban C, Lutz B, Straiker A, Dehghani F. (2012) The endocannabinoid N-arachidonoyldopamine (NADA) exerts neuroprotective effects after excitotoxic neuronal damage via cannabinoid receptor 1 (CB(1)). Neuropharmacology. 62(4):1797-807.

Hezel M, Ebrahimi F, Koch M, Dehghani F. (2012) Propidium iodide staining: a new application in fluorescence microscopy for analysis of cytoarchitecture in adult and developing rodent brain. Micron. 43(10):1031-8.

Kallendrusch S, Hobusch C, Ehrlich A, Nowicki M, Ziebell S, Bechmann I, Geisslinger G, Koch M, Dehghani F. (2012) Intrinsic Up-Regulation of 2-AG Favors an Area Specific Neuronal Survival in Different In Vitro Models of Neuronal Damage. PLoS One. 7(12):e51208.

Kallendrusch S, Hobusch C, Ehrlich A, Ziebell S, Ueda N, Geisslinger G, Koch M, Dehghani F. (2012) Site-specific and time-dependent activation of the endocannabinoid system after transection of long-range projections. PLoS One. 7(3):e33537.

AG Prof. Fischer

Biemann R, Navarrete Santos An, Navarrete Santos Al, Riemann D, Knelangen J, Blüher M, Fischer B. (2012) Endocrine disrupting chemicals affect the adipogenic differentiation of mesenchymal stem cells in distinct ontogenetic windows. Biochem Biophys Res Commun. 417:747-52.

Duranthon V, Beaujean N, Brunner M, Odening KE, Santos AN, Kacskovics I, Hiripi L, Weinstein EJ, Bosze Z. (2012) On the emerging role of rabbit as human disease model and the instrumental role of novel transgenic tools.Transgenic Res. 21(4):699-713.

Fischer B, Chavatte-Palmer P, Viebahn C, Navarrete Santos A, Duranthon V. (2012) Rabbit as a reproductive model for human health. Reproduction. 144:1-10.

Fowler PA, Bellingham M, Sinclair KD, Evans NP, Pocar P, Fischer B, Schaedlich K, Schmidt JS, Amezaga MR, Bhattacharya S, Rhind SM, O'Shaughnessy PJ. (2012) Impact of endocrine-disrupting compounds (EDCs) on female reproductive health. Mol Cell Endocrinol. 355:231-39.

Knelangen JM, Kurz R, Schagdarsurengin U, Fischer B, Navarrete Santos A. (2012) Short-time glucose exposure of embryonic carcinoma cells impairs their function as terminally differentiated cardiomyocytes. Biochem Biophys Res Commun. 420:230-5.

Königsdorf CAI, Navarrete Santos A, Schmidt JS, Fischer S, Fischer B. (2012) Expression profile of fatty acid metabolism genes in preimplantation blastocysts of obese and non-obese mice. Obesity Facts. 5:575–86.

Llobat L, Marco-Jiménez F, Peñaranda DS, Thieme R, Navarrete Santos A, Vicente JS. (2012) mRNA expression in rabbit blastocyst and endometrial tissue of candidate gene involved in gestational losses. Reprod Dom Anim. 47:281-7.

Pocar P, Fiandanese N, Secchi C, Berrini A, Fischer B, Schmidt JS, Schaedlich K, Borromeo V. (2012) Exposure to di(2-ethyl-hexyl) phthalate (DEHP) in utero and during lactation causes long-term pituitary-gonadal axis disruption in mouse male and female offspring. Endocrinology. 153:937-48.

Pocar P, Fiandanese N, Secchi C, Berrini A, Fischer B, Schmidt JS, Schaedlich K, Rhind SM, Zhang Z, Borromeo V. (2012) Effects of polychlorinated biphenyls in CD-1 mice: reproductive toxicity and intergenerational transmission. Toxicol Sci. 126:213-26.

Schmidt JS, Schaedlich K, Fiandanese N, Pocar P, Fischer B. (2012) Effects of Di(2-ethylhexyl) Phthalate (DEHP) on Female Fertility and Adipogenesis in C3H/N mice. Environmental Health Perspectives. 120:1123-9.

Schroeder IS, Sulzbacher S, Nolden T, Fuchs J, Czarnota J, Meisterfeld R, Himmelbauer H, Wobus AM. (2012) Induction and selection of sox17-expressing endoderm cells generated from murine embryonic stem cells. Cells Tissues Organs. 195:507-23.

Thieme R, Ramin N, Fischer S, Püschel B, Fischer B, Navarrete Santos A. (2012) Gastrulation in rabbit blastocysts depends on insulin and the insulin-like-growth-factor 1. Mol Cell Endocrinol. 348:112-9.

Thieme R, Schindler M, Ramin N, Fischer S, Mühleck B, Fischer B, Navarrete Santos A. (2012) Insulin growth factor adjustment in preimplantation rabbit blastocysts and uterine tissues in response to maternal type 1 diabetes. Mol Cell Endocrinol. 358:96-103.

Prof. Peschke

Bähr I, Bazwinsky-Wutschke I, Wolgast S, Hofmann K, Streck S, Mühlbauer E, Wedekind D, Peschke E. (2012) GLUT4 in the endocrine pancreas--indicating an impact in pancreatic islet cell physiology? Horm Metab Res. 44(6):442-50.

Bähr I, Mühlbauer E, Albrecht E, Peschke E. (2012) Evidence of the receptor-mediated influence of melatonin on pancreatic glucagon secretion via the Gαq protein-coupled and PI3K signaling pathways. J Pineal Res. 53:390-8.

Bazwinsky-Wutschke I, Wolgast S, Mühlbauer E, Albrecht E, Peschke E. (2012) Phosphorylation of cyclic AMP-response element-binding protein (CREB) is influenced by melatonin treatment in pancreatic rat insulinoma β-cells (INS-1). J Pineal Res. 53(4):344-57.

Mühlbauer E, Albrecht E, Bazwinsky-Wutschke I, Peschke E. (2012) Melatonin influences insulin secretion primarily via MT(1) receptors in rat insulinoma cells (INS-1) and mouse pancreatic islets. J Pineal Res. 52(4):446-59.


AG Prof. Kielstein

Held N, Smits BMG, Gockeln R, Schubert S, Nave H, Northrup E, Cuppen E, Hedrich HJ, Wedekind D. (2011) A mutation in Myo15 leads to Usher-like symptoms in LEW/Ztm-ci2 rats. PLoS One. 6:e15669.

Jäger K, Nielitz A, Garreis F, Sel S, Nave H, Paulsen FP. (2011) In vitro evidence of involvement of the epithelial y+ transporter in β-defensin production on the ocular surface. Ann Anat. 193:479-85.

Lautenbach A, Breitmeier D, Kuhlmann S, Nave H. (2011) Human obesity reduces the number of hepatic leptin receptor (ob-R) expressing NK cells. Endocr Res. 36:158-66.

Nave H, Beutel G, Kielstein JT. (2011) Obesity-related immunodeficiency as a major risk factor in patients with pandemic influenza A (H1N1) virus infection. Lancet Infect Dis. 11:14-15.

Stadler J, Le TP, Haas P, Nave H. (2011) Distinct effects of NPY13-36, a specific NPY Y2 agonist, in a model of rodent endotoxemia on leukocyte subsets and cytokine levels. Ann Anat. 193:486-93.

Stephan M, Radicke A, Leutloff S, Schmiedl A, Pabst R, von Hörsten S, Dettmer S, Lotz J, Nave H. (2011) Dipeptidyl peptidase IV (DPP4)-deficiency attenuates diet-induced obesity in rats: possible implications for the hypothalamic neuropeptidergic system. Behav Brain Res. 216:712-8.

AG Prof. Dehghani

Koch M, Kreutz S, Böttger C, Benz A, Maronde E, Ghadban C, Korf HW, Dehghani F. (2011) Palmitoylethanolamide protects dentate gyrus granule cells via peroxisome proliferator-activated receptor-α. Neurotox Res. 19(2):330-40.

Koch M, Kreutz S, Böttger C, Grabiec U, Ghadban C, Korf HW, Dehghani F. (2011) The cannabinoid WIN 55,212-2-mediated protection of dentate gyrus granule cells is driven by CB1 receptors and modulated by TRPA1 and Cav 2.2 channels. Hippocampus. 21(5):554-64.

Maronde E, Saade A, Ackermann K, Goubran-Botros H, Pagan C, Bux R, Bourgeron T, Dehghani F, Stehle JH. (2011) Dynamics in enzymatic protein complexes offer a novel principle for the regulation of melatonin synthesis in the human pineal gland. J Pineal Res. 5(1):145-55.

AG Prof. Fischer

Horling K, Navarrete Santos A, Fischer B. (2011) The AhR is constitutively activated and affects granulosa cell features in the human cell line KGN. Mol Hum Reprod. 17:104-14.

Knelangen J, van der Hoek M, Kong WC, Owens J, Fischer B, Navarrete Santos A. (2011) MicroRNA expression profile during adipogenic differentiation in mouse embryonic stem cells. Physiol Genomics. 43:611-20.

Willing C, Peich M, Danescu A, Kehlen A, Fowler PA, Hombach-Klonisch S. (2011) Estrogen-independent actions of environmentally relevant AhR-agonists in human endometrial epithelial cells. Mol Hum Reprod. 17:115-26.

apl. Prof. Claassen

Claassen H, Schicht M, Brandt J, Reuse K, Schädlich R, Goldring MB, Guddat SS, Thate A, Paulsen F. (2011) C-28/I2 and T/C-28a2 chondrocytes as well as human primary articular chondrocytes express sex hormone and insulin receptors--Useful cells in study of cartilage metabolism. Ann Anat. 193:23-9.

Claassen H, Schicht M, Paulsen F. (2011) Impact of sex hormones, insulin, growth factors and peptides on cartilage health and disease. Prog Histochem Cytochem. 45:239-93.

Prof. Peschke

Bähr I, Mühlbauer E, Schucht H, Peschke E. (2011) Melatonin stimulates glucagon secretion in vitro and in vivo. J Pineal Res. 50:336-44.

Bazwinsky-Wutschke I, Paulsen F, Stövesandt D, Holzhausen HJ, Heine HJ, Peschke E. (2011) Anatomical changes after pneumonectomy. Ann Anat. 193(2):168-72.

Mühlbauer E, Albrecht E, Hofmann K, Bazwinsky-Wutschke I, Peschke E. (2011) Melatonin inhibits insulin secretion in rat insulinoma β-cells (INS-1) heterologously expressing the human melatonin receptor isoform MT2. J Pineal Res. 51(3):361-72.

Peschke E, Hofmann K, Bähr I, Streck S, Albrecht E, Wedekind D, Mühlbauer E. (2011) The insulin-melatonin antagonism: studies in the LEW.1AR1-iddm rat (an animal model of human type 1 diabetes mellitus). Diabetologia. 54:1831-40.

Prof. Paulsen

Bazwinsky-Wutschke I, Paulsen F, Stövesandt D, Holzhausen HJ, Heine HJ, Peschke E. (2011) Anatomical changes after pneumonectomy. Ann Anat. 193(2):168-72.

Garreis F, Gottschalt M, Schlorf T, Gläser R, Harder J, Worlitzsch D, Paulsen FP. (2011) Expression and regulation of antimicrobial peptide psoriasin (S100A7) at the ocular surface and in the lacrimal apparatus. Invest Ophth Vis Sci. 52:4914-22.


Prof. Dr. Heike Kielstein

Medizinische Fakultät
Institut für Anatomie und Zellbiologie
Große Steinstraße 52
06108 Halle (Saale)

06097 Halle (Saale) - Postanschrift

Prof. Dr. med. 
Heike Kielstein

Prof. Dr. med. 
Faramarz Dehghani

Evelyn Axmann
Elisabeth George
Antje Harbach

(+49) (345) 557 - 1701, -1702, -1703
Fax: (+49) (345) 557 - 1700

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