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Research

Our lab is interested in the characterization of regulatory mechanisms directing the cytoplasmic fate of specific mRNAs and how this posttranscriptional control of gene expression modulates cell function and pathogenesis, in particular tumor progression. 

The cytoplasmic control of gene expression is essentially facilitated by two classes of molecular regulators, RNA-binding proteins and non-coding (nc) RNAs. Projects in the lab focus on RNA binding proteins of the IGF2BP (IGF2 mRNA binding protein) family, various microRNAs directing the expression of transcription factors and finally a group of four ncRNAs in human, termed Y-RNAs.  How these regulators modulate the migration, invasiveness and/or trans-differentiation (EMT) of tumor cells is a key interest of ongoing projects in the lab.