UNR/CSDE1 Drives a Post-transcriptional Program to Promote Melanoma Invasion and Metastasis. Laurence Wurth, Panagiotis Papasaikas, David Olmeda, Nadine Bley, Guadalupe T. Calvo, Santiago Guerrero, Daniela Cerezo-Wallis, Javier Martinez-Useros, María García-Fernández, Stefan Hüttelmaier, Maria S. Soengas, Fátima Gebauer. PMID: 27908735. DOI:

Möller B, Glaß M, Misiak D, Posch S. MiToBo - A Toolbox for Image Processing and Analysis. Journal of Open Research Software. 2016;4(1):e17. DOI:

Rietscher K, Wolf A, Hause G, Rother A, Keil R, Magin TM, Glass M, Niessen CM, Hatzfeld M. Growth retardation, loss of desmosomal adhesion and impaired tight junction function identify a unique role of plakophilin 1 in vivo. J Invest Dermatol. 2016 Mar 28. pii: S0022-202X(16)30984-8. doi: 10.1016/j.jid.2016.03.021. [Epub ahead of print] PubMed PMID: 27033150

Köhn M, Hüttelmaier S. Non-coding RNAs, the cutting edge of histone messages. RNA Biol. 2016 Feb 24:0. [Epub ahead of print] PubMed PMID: 26909464.

Busch B, Bley N, Müller S, Glaß M, Misiak D, Lederer M, Vetter M, Strauß HG, Thomssen C, Hüttelmaier S. The oncogenic triangle of HMGA2, LIN28B and IGF2BP1 antagonizes tumor-suppressive actions of the let-7 family. Nucleic Acids Res. 2016 Feb 24. pii: gkw099. [Epub ahead of print] PubMed PMID: 26917013.

Bretschneider M, Busch B, Mueller D, Nolze A, Schreier B, Gekle M, Grossmann C. Activated mineralocorticoid receptor regulates micro-RNA-29b in vascular smooth muscle cells. FASEB J. 2016 Jan 4. pii: fj.15-271254. [Epub ahead of print] PubMed PMID: 26728178. 


Sun Y, Bell JL, Carter DR, Gherardi S, Poulos RC, Milazzo G, Wong JW, Al-Awar R, Tee AE, Liu PY, Liu B, Atmadibrata B, Wong M, Trahair T, Zhao Q, Shohet JM, Haupt Y, Schulte JH, Brown PJ, Arrowsmith CH, Vedadi M, MacKenzie KL, Huttelmaier S, Perini G, Marshall GM, Braithwaite A, Liu T. WDR5 supports an N-Myc transcriptional complex that drives a pro-tumorigenic gene expression signature in neuroblastoma. Cancer Res. 2015 Oct 15. pii: canres.0423.2015. [Epub ahead of print] PubMed PMID: 26471359.

Köhn M, Ihling C, Sinz A, Krohn K, Hüttelmaier S. The Y3** ncRNA promotes the 3' end processing of histone mRNAs. Genes Dev. 2015 Oct 1;29(19):1998-2003. doi: 10.1101/gad.266486.115. PubMed PMID: 26443846; PubMed Central PMCID: PMC4604341.

Jasinski-Bergner S, Stoehr C, Bukur J, Massa C, Braun J, Hüttelmaier S, Spath V, Wartenberg R, Legal W, Taubert H, Wach S, Wullich B, Hartmann A, Seliger B. Clinical relevance of miR-mediated HLA-G regulation and the associated immune cell infiltration in renal cell carcinoma. Oncoimmunology. 2015 Mar 2;4(6):e1008805. eCollection 2015 Jun. PubMed PMID: 26155421; PubMed Central PMCID: PMC4485830.

Bell JL, Turlapati R, Liu T, Schulte JH, Hüttelmaier S. IGF2BP1 Harbors Prognostic Significance by Gene Gain and Diverse Expression in Neuroblastoma. J Clin Oncol. 2015 Mar 9. pii: JCO.2014.55.9880. [Epub ahead of print] PubMed PMID:25753434.



Bley N, Lederer M, Pfalz B, Reinke C, Fuchs T, Glaß M, Möller B, Hüttelmaier S. Stress granules are dispensable for mRNA stabilization during cellular stress. Nucleic Acids Res. 2014 Dec 8. pii: gku1275. [Epub ahead of print] PubMed PMID: 25488811.

Lederer M, Bley N, Schleifer C, Hüttelmaier S. The role of the oncofetal IGF2 mRNA-binding protein 3 (IGF2BP3) in cancer. Semin Cancer Biol. 2014 Dec;29:3-12. doi: 10.1016/j.semcancer.2014.07.006. Epub 2014 Jul 25. PubMed PMID: 25068994.

Jasinski-Bergner S, Stehle F, Gonschorek E, Kalich J, Schulz K, Huettelmaier S, Braun J, Seliger B. Identification of 14-3-3β gene as a novel miR-152 target using a proteome-based approach. J Biol Chem. 2014 Nov 7;289(45):31121-35. doi: 10.1074/jbc.M114.556290. Epub 2014 Sep 16. PubMed PMID: 25228695; PubMed Central PMCID: PMC4223316.

Liu PY, Erriquez D, Marshall GM, Tee AE, Polly P, Wong M, Liu B, Bell JL, Zhang XD, Milazzo G, Cheung BB, Fox A, Swarbrick A, Hüttelmaier S, Kavallaris M, Perini G, Mattick JS, Dinger ME, Liu T. Effects of a novel long noncoding RNA, lncUSMycN, on N-Myc expression and neuroblastoma progression. J Natl Cancer Inst. 2014 Jun 6;106(7). pii: dju113. doi: 10.1093/jnci/dju113. Print 2014 Jul. Erratumin: J Natl Cancer Inst. 2015 ; Jan;107(1):doi/10.1093/jnci/dju359. PubMed PMID:24906397.

Gutschner T, Hämmerle M, Pazaitis N, Bley N, Fiskin E, Uckelmann H, Heim A, Groβ M, Hofmann N, Geffers R, Skawran B, Longerich T, Breuhahn K, Schirmacher P, Mühleck B, Hüttelmaier S, Diederichs S. Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an important protumorigenic factor in hepatocellular carcinoma. Hepatology. 2014 May;59(5):1900-11. doi: 10.1002/hep.26997. Epub 2014 Apr 1. PubMed PMID: 24395596. 

Braun J, Misiak D, Busch B, Krohn K, Hüttelmaier S. Rapid identification of regulatory microRNAs by miTRAP (miRNA trapping by RNA in vitro affinity purification). Nucleic Acids Res. 2014 Apr 1;42(8):e66. doi: 10.1093/nar/gku127. Epub 2014 Feb 7. PubMed PMID: 24510096; PubMed Central PMCID: PMC4005655.

Misiak D, Posch S, Lederer M, Reinke C, Hüttelmaier S, Möller B. Extraction of protein profiles from primary neurons using active contour models and wavelets. Journal of Neuroscience Methods, Volume 225, 30 March 2014, Pages 1-12. pii: S0165-0270(13)00433-0. doi: 10.1016/j.jneumeth.2013.12.009. [Epub ahead of print] PubMed PMID: 24457055.



Seltmann K, Roth W, Kröger C, Loschke F, Lederer M, Hüttelmaier S, Magin TM. Keratins mediate localization of hemidesmosomes and repress cell motility. J Invest Dermatol. 2013 Jan;133(1):181-90. doi: 10.1038/jid.2012.256. Epub 2012 Aug 16. PubMed PMID: 22895363; PubMed Central PMCID: PMC3575009.

Nolze A, Schneider J, Keil R, Lederer M, Hüttelmaier S, Kessels MM, Qualmann B, Hatzfeld M. FMRP regulates actin filament organization via the armadillo protein p0071. RNA. 2013 Nov;19(11):1483-96. doi: 10.1261/rna.037945.112. Epub 2013 Sep 23. PubMed PMID: 24062571; PubMed Central PMCID: PMC3851716.

Bell JL, Wächter K, Mühleck B, Pazaitis N, Köhn M, Lederer M, Hüttelmaier S. Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression? Cell Mol Life Sci. 2013 Aug;70(15):2657-75. doi: 10.1007/s00018-012-1186-z. Epub 2012 Oct 16. Review. PubMed PMID: 23069990; PubMed Central PMCID: PMC3708292.

Zirkel A, Lederer M, Stöhr N, Pazaitis N, Hüttelmaier S. IGF2BP1 promotes mesenchymal cell properties and migration of tumor-derived cells by enhancing the expression of LEF1 and SNAI2 (SLUG). Nucleic Acids Res. 2013 May 15. [Epub ahea of print] PubMed PMID: 23677615.

Wächter K, Köhn M, Stöhr N, Hüttelmaier S. Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA binding proteins) is modulated by distinct RNA-binding domains. Biol Chem. 2013 May 1. doi:10.1515/hsz-2013-0111. [Epub ahead of print] PubMed PMID: 23640942

Köhn M, Pazaitis N, Hüttelmaier S. Why YRNAs? About Versatile RNAs and Their Functions. Biomolecules. 2013 Feb 8;3(1):143-56. doi: 10.3390/biom3010143. PubMed PMID: 24970161; PubMed Central PMCID: PMC4030889.

Wolf A, Rietscher K, Glaß M, Hüttelmaier S, Schutkowski M, Ihling C, Sinz A, Wingenfeld A, Mun A, Hatzfeld M. Insulin signaling via Akt2 switches plakophilin 1 functions from stabilizing cell adhesion to promoting cell proliferation. J Cell Sci. 2013 Feb 26. [Epub ahead of print] PubMed PMID: 23444369.



Glaß M, Möller B, Posh S. Scratch Assay Analysis in ImageJ. In Proc. of ImageJ User and Developer Conference, vol. 1, pp. 211-214, Luxembourg, October 2012.

Möller B, Misiak D. SnakeOptimizer - Object Segmentation with Parametric Active Contours in ImageJ. In Proc. of ImageJ User and Developer Conference, vol. 1, pp. 215-218, Luxembourg, October 2012.

Glaß M, Möller B, Zirkel A, Wächter K, Hüttelmaier S, Posch S. Cell migration analysis: Segmenting scratch assay images with level sets and support vector machines. Pattern Recognition, Volume 45, Issue 9, September 2012, Pages 3154-3165, ISSN 0031-3203, 10.1016/j.patcog.2012.03.00.

Stöhr N, Hüttelmaier S. IGF2BP1: a post-transcriptional "driver" of tumor cell migration. Cell Adh Migr. 2012 Jul-Aug;6(4):312-8. doi: 10.4161/cam.20628. Epub 2012 Jul 1. PubMed PMID: 22983196; PubMed Central PMCID: PMC3478252.

Berndt H, Harnisch C, Rammelt C, Stöhr N, Zirkel A, Dohm JC, Himmelbauer H,Tavanez JP, Hüttelmaier S, Wahle E. Maturation of mammalian H/ACA box snoRNAs: PAPD5-dependent adenylation and PARN-dependent trimming. RNA. 2012 May;18(5):958-72. Epub 2012 Mar 22. PMID: 22442037.

Stöhr N, Köhn M, Lederer M, Glaß M, Reinke C, Singer RH, Hüttelmaier S. IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling. Genes Dev. 2012 Jan 15;26(2):176-189. PubMed PMID: 22279049.



Fronz K, Güttinger S, Burkert K, Kühn U, Stöhr N, Schierhorn A, Wahle E. Arginine methylation of the nuclear poly(A) binding protein weakens the interaction with its nuclear import receptor, transportin. J Biol Chem. 2011 Aug 1. [Epub ahead of print] PubMed PMID: 21808065. 

Braun J, Hüttelmaier S. Pathogenic mechanisms of deregulated microRNA expression in thyroid carcinomas of follicular origin. Thyroid Research. 2011 August 3; vol. 4. PubMed PMID: 21835047; PubMed Central PMCID: PMC3155107.

Glaß M, Möller B, Zirkel A, Wächter K, Hüttelmaier S, Posch S. Scratch assay analysis with topology-preserving level sets and texture measures. Proc. of 5th Iberian Conference on Pattern Recognition and Image Analysis (IbPRIA '11), pages 100-108, Gran Canaria, Spain, 2011



Möller B, Stöhr N, Hüttelmaier S, Posch S. Cascaded Segmentation of Grained Cell Tissue with Active Contour Models. In Proc. of Int. Conf. on Pattern Recognition (ICPR), IEEE, pp. 1481-1484, Istanbul, Turkey, August 2010.

Braun J, Hoang-Vu C, Dralle H, Hüttelmaier S. Downregulation of microRNAs directs the EMT and invasive potential of anaplastic thyroid carcinomas. Oncogene. 2010 May 24. [Epub ahead of print] PubMed PMID: 20498632.

Köhn M, Lederer M, Wächter K, Hüttelmaier S. Near-infrared (NIR) dye-labeled RNAs identify binding of ZBP1 to the noncoding Y3-RNA. RNA. 2010 Jul;16(7):1420-8. Epub 2010 May 21. PubMed PMID: 20494969; PubMed Central PMCID: PMC2885690.

Möller B, Greß O, Stöhr N, Hüttelmaier S, Posch S. Adaptive segmentation of cells and particles in fluorescent microscope images. In Proc. of International Conference on Computer Vision Theory and Applications (VISAPP '10), vol. 2, pp. 97-106, Angers, France, May 2010.

Wolf A, Krause-Gruszczynska M, Birkenmeier O, Ostareck-Lederer A, Hüttelmaier S, Hatzfeld M. Plakophilin 1 stimulates translation by promoting eIF4A1 activity.J Cell Biol. 2010 Feb 22;188(4):463-71. Epub 2010 Feb 15. PubMed PMID: 20156963; PubMed Central PMCID: PMC2828926.



Misiak D, Posch S, Stöhr N, Hüttelmaier S, Möller B. Automatic analysis of fluorescence labeled neurites in microscope images. In IEEE Workshop an Applications of Computer Vision (WACV '09), pages 118-124, 2009. IEEE Catalog Number CFP09082-CDR.

Weinlich S, Hüttelmaier S, Schierhorn A, Behrens SE, Ostareck-Lederer A, Ostareck DH. IGF2BP1 enhances HCV IRES-mediated translation initiation via the 3'UTR. RNA. 2009 Aug;15(8):1528-42. Epub 2009 Jun 18. PubMed PMID: 19541769; PubMed Central PMCID: PMC2714754.



Weidensdorfer D, Stöhr N, Baude A, Lederer M, Köhn M, Schierhorn A, Buchmeier S, Wahle E, Hüttelmaier S. Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs. RNA. 2009 Jan;15(1):104-15. Epub 2008 Nov 24. PubMed PMID: 19029303; PubMed Central PMCID: PMC2612774.

White R, Gonsior C, Krämer-Albers EM, Stöhr N, Hüttelmaier S, Trotter J. Activation of oligodendroglial Fyn kinase enhances translation of mRNAs transported in hnRNP A2-dependent RNA granules. J Cell Biol. 2008 May 19;181(4):579-86. PubMed PMID: 18490510; PubMed Central PMCID: PMC2386098.



Pan F, Hüttelmaier S, Singer RH, Gu W. ZBP2 facilitates binding of ZBP1 to beta-actin mRNA during transcription. Mol Cell Biol. 2007 Dec;27(23):8340-51. Epub 2007 Sep 24. Erratum in: Mol Cell Biol. 2009 May;29(9):2481. PubMed PMID: 17893325; PubMed Central PMCID: PMC2169170.

Köbel M, Weidensdorfer D, Reinke C, Lederer M, Schmitt WD, Zeng K, Thomssen C, Hauptmann S, Hüttelmaier S. Expression of the RNA-binding protein IMP1 correlates with poor prognosis in ovarian carcinoma. Oncogene. 2007 Nov 29;26(54):7584-9. Epub 2007 Jun 4. PubMed PMID: 17546046.

Keil R, Wolf A, Hüttelmaier S, Hatzfeld M. Beyond regulation of cell adhesion: local control of RhoA at the cleavage furrow by the p0071 catenin. Cell Cycle. 2007 Jan 15;6(2):122-7. Epub 2007 Jan 19. Review. PubMed PMID: 17264675.



Wolf A, Keil R, Götzl O, Mun A, Schwarze K, Lederer M, Hüttelmaier S, Hatzfeld M. The armadillo protein p0071 regulates Rho signalling during cytokinesis. Nat Cell Biol. 2006 Dec;8(12):1432-40. Epub 2006 Nov 19. PubMed PMID: 17115030.

Stöhr N, Lederer M, Reinke C, Meyer S, Hatzfeld M, Singer RH, Hüttelmaier S. ZBP1 regulates mRNA stability during cellular stress. J Cell Biol. 2006 Nov 20;175(4):527-34. Epub 2006 Nov 13. PubMed PMID: 17101699; PubMed Central PMCID: PMC2064588.

Rideau AP, Gooding C, Simpson PJ, Monie TP, Lorenz M, Hüttelmaier S, Singer RH, Matthews S, Curry S, Smith CW. A peptide motif in Raver1 mediates splicing repression by interaction with the PTB RRM2 domain. Nat Struct Mol Biol. 2006 Sep;13(9):839-48. Epub 2006 Aug 27. PubMed PMID: 16936729.

Köbel M, Langhammer T, Hüttelmaier S, Schmitt WD, Kriese K, Dittmer J, Strauss HG, Thomssen C, Hauptmann S. Ezrin expression is related to poor prognosis in FIGO stage I endometrioid carcinomas. Mod Pathol. 2006 Apr;19(4):581-7. PubMed PMID: 16554733.

Ostareck-Lederer A, Ostareck DH, Rucknagel KP, Schierhorn A, Moritz B, Hüttelmaier S, Flach N, Handoko L, Wahle E. Asymmetric arginine dimethylation of heterogeneous nuclear ribonucleoprotein K by protein-arginine methyltransferase 1 inhibits its interaction with c-Src. J Biol Chem. 2006 Apr 21;281(16):11115-25. Epub 2006 Feb 21. PubMed PMID: 16492668.

Boukhelifa M, Moza M, Johansson T, Rachlin A, Parast M, Hüttelmaier S, Roy P, Jockusch BM, Carpen O, Karlsson R, Otey CA. The proline-rich protein palladin is a binding partner for profilin. FEBS J. 2006 Jan;273(1):26-33. PubMed PMID: 16367745.



Hüttelmaier S, Zenklusen D, Lederer M, Dictenberg J, Lorenz M, Meng X, Bassell GJ, Condeelis J, Singer RH. Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1. Nature. 2005 Nov 24;438(7067):512-5. PubMed PMID: 16306994.

Faul C, Hüttelmaier S, Oh J, Hachet V, Singer RH, Mundel P. Promotion of importin alpha-mediated nuclear import by the phosphorylation-dependent binding of cargo protein to 14-3-3. J Cell Biol. 2005 May 9;169(3):415-24. PubMed PMID: 15883195; PubMed Central PMCID: PMC2171942.



Niessing D, Hüttelmaier S, Zenklusen D, Singer RH, Burley SK. She2p is a novel RNA binding protein with a basic helical hairpin motif. Cell. 2004 Nov 12;119(4):491-502. PubMed PMID: 15537539.



Gromak N, Rideau A, Southby J, Scadden AD, Gooding C, Hüttelmaier S, Singer RH, Smith CW. The PTB interacting protein raver1 regulates alpha-tropomyosin alternative splicing. EMBO J. 2003 Dec 1;22(23):6356-64. PubMed PMID: 14633994; PubMed Central PMCID: PMC291850.

Jockusch BM, Hüttelmaier S, Illenberger S. From the nucleus toward the cell periphery: a guided tour for mRNAs. News Physiol Sci. 2003 Feb;18:7-11. Review. PubMed PMID: 12531924.



Farina KL, Hüttelmaier S, Musunuru K, Darnell R, Singer RH. Two ZBP1 KH domains facilitate beta-actin mRNA localization, granule formation, and cytoskeletal attachment. J Cell Biol. 2003 Jan 6;160(1):77-87. Epub 2002 Dec 30. PubMed PMID: 12507992; PubMed Central PMCID: PMC2172732.

Chartrand P, Meng XH, Hüttelmaier S, Donato D, Singer RH. Asymmetric sorting of ash1p in yeast results from inhibition of translation by localization elements in the mRNA. Mol Cell. 2002 Dec;10(6):1319-30. PubMed PMID: 12504008.

Wang W, Wyckoff JB, Frohlich VC, Oleynikov Y, Hüttelmaier S, Zavadil J, Cermak L, Bottinger EP, Singer RH, White JG, Segall JE, Condeelis JS. Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling. Cancer Res. 2002 Nov 1;62(21):6278-88. Erratum in: Cancer Res 2002 Dec 1;62(23):7132. PubMed PMID: 12414658.

Olson TM, Illenberger S, Kishimoto NY, Hüttelmaier S, Keating MT, Jockusch BM. Metavinculin mutations alter actin interaction in dilated cardiomyopathy. Circulation. 2002 Jan 29;105(4):431-7. PubMed PMID: 11815424.



Hüttelmaier S, Illenberger S, Grosheva I, Rüdiger M, Singer RH, Jockusch BM. Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and microfilament attachment proteins. J Cell Biol. 2001 Nov 26;155(5):775-86. Epub 2001 Nov 26. PubMed PMID: 11724819; PubMed Central PMCID: PMC2150882.



Harbeck B, Hüttelmaier S, Schluter K, Jockusch BM, Illenberger S. Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin. J Biol Chem. 2000 Oct 6;275(40):30817-25. PubMed PMID: 10882740.



Hüttelmaier S, Harbeck B, Steffens O, Messerschmidt T, Illenberger S, Jockusch BM. Characterization of the actin binding properties of the vasodilator-stimulated phosphoprotein VASP. FEBS Lett. 1999 May 14;451(1):68-74. PubMed PMID: 10356985.



Hüttelmaier S, Mayboroda O, Harbeck B, Jarchau T, Jockusch BM, Rüdiger M. The interaction of the cell-contact proteins VASP and vinculin is regulated by phosphatidylinositol-4,5-bisphosphate. Curr Biol. 1998 Apr 23;8(9):479-88. PubMed PMID: 9560340.



Hüttelmaier S, Bubeck P, Rüdiger M, Jockusch BM. Characterization of two F-actin-binding and oligomerization sites in the cell-contact protein vinculin. Eur J Biochem. 1997 Aug 1;247(3):1136-42. PubMed PMID: 9288940.