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Publications

Götze M, Dufourt J, Ihling C, Rammelt C, Pierson S, Sambrani N, Temme C, Sinz A, Simonelig M, Wahle E. Translational repression of the Drosophila nanos mRNA involves the RNA helicase Belle and RNA coating by Me31B and Trailer hitch. RNA. 2017 Oct;23(10):1552-1568. doi: 10.1261/rna.062208.117. Epub 2017 Jul 12. PubMed PMID: 28701521; PubMed Central PMCID: PMC5602113.

Zhou F, Liu Y, Rohde C, Pauli C, Gerloff D, Köhn M, Misiak D, Bäumer N, Cui C, Göllner S, Oellerich T, Serve H, Garcia-Cuellar MP, Slany R, Maciejewski JP, Przychodzen B, Seliger B, Klein HU, Bartenhagen C, Berdel WE, Dugas M, Taketo MM, Farouq D, Schwartz S, Regev A, Hébert J, Sauvageau G, Pabst C, Hüttelmaier S, Müller-Tidow C. AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia. Nat Cell Biol. 2017 Jul;19(7):844-855. doi: 10.1038/ncb3563. Epub 2017 Jun 26. PubMed PMID: 28650479. 

Wong M, Tee AE, Milazzo G, Bell JL, Poulos RC, Atmadibrata B, Sun Y, Jing D, Ho N, Ling D, Liu PY, Zhang XD, Hüttelmaier S, Wong JW, Wang J, Polly P, Perini G, Scarlett CJ, Liu T. The histone methyltransferase DOT1L promotes neuroblastoma by regulating gene transcription. Cancer Res. 2017 Feb 16. pii: canres.1663.2016. doi: 10.1158/0008-5472.CAN-16-1663. [Epub ahead of print] PubMed PMID: 28209620. 

Kühn U, Buschmann JWahle E. The nuclear poly(A) binding protein of mammals, but not of fission yeast, participates in mRNA polyadenylation. RNA. 2017 Apr;23(4):473-482. doi: 10.1261/rna.057026.116. Epub 2017 Jan 17. PubMed PMID: 28096519; PubMed Central PMCID: PMC5340911.

Wurth L, Papasaikas P, Olmeda D, Bley N, Calvo GT, Guerrero S, Cerezo-Wallis D, Martinez-Useros J, García-Fernández M, Hüttelmaier S, Soengas MS, Gebauer F. UNR/CSDE1 Drives a Post-transcriptional Program to Promote Melanoma Invasion and Metastasis. Cancer Cell. 2016 Nov 14;30(5):694-707. doi: 10.1016/j.ccell.2016.10.004. Epub 2016 Oct 27. PubMed PMID: 27908735.

Jasinski-Bergner S, Reches A, Stoehr C, Massa C, Gonschorek E, Huettelmaier SBraun J, Wach S, Wullich B, Spath V, Wang E, Marincola FM, Mandelboim O, Hartmann A, Seliger B. Identification of novel microRNAs regulating HLA-G expression and investigating their clinical relevance in renal cell carcinoma. Oncotarget. 2016 May 3;7(18):26866-78. doi: 10.18632/oncotarget.8567. PubMed PMID: 27057628; PubMed Central PMCID: PMC5042021.

Möller B, Glaß M, Misiak D, Posch S. MiToBo - A Toolbox for Image Processing and Analysis. Journal of Open Research Software. 2016;4(1):e17. DOI: doi.org/10.5334/jors.103 

Harnisch C, Cuzic-Feltens S, Dohm JC, Götze M, Himmelbauer H, Wahle E. Oligoadenylation of 3' decay intermediates promotes cytoplasmic mRNA degradation in Drosophila cells. RNA. 2016 Mar;22(3):428-42. doi: 10.1261/rna.053942.115. Epub 2016 Jan 19. PubMed PMID: 26786835; PubMed Central PMCID: PMC4748820.

Busch BBley N, Müller S, Glaß M, Misiak D, Lederer M, Vetter M, Strauß HG, Thomssen C, Hüttelmaier S. The oncogenic triangle of HMGA2, LIN28B and IGF2BP1 antagonizes tumor-suppressive actions of the let-7 family. Nucleic Acids Res. 2016 Feb 24. pii: gkw099. [Epub ahead of print] PubMed PMID: 26917013.

Bretschneider M, Busch B, Mueller D, Nolze A, Schreier BGekle MGrossmann C. Activated mineralocorticoid receptor regulates micro-RNA-29b in vascular smooth muscle cells. FASEB J. 2016 Jan 4. pii: fj.15-271254. [Epub ahead of print] PubMed PMID: 26728178. 

Rothe K, Quandt D, Schubert K, Rossol M, Klingner M, Jasinski-Bergner S, Scholz R, Seliger B, Pierer M, Baerwald C, Wagner U. Latent Cytomegalovirus Infection in Rheumatoid Arthritis and Increased Frequencies of Cytolytic LIR-1+CD8+ T Cells. Arthritis Rheumatol. 2016 Feb;68(2):337-46. doi: 10.1002/art.39331. PubMed PMID: 26314621.

Stehle F, Leisz S, Schulz K, Schwurack N, Weber N, Massa C, Kalich J, Fahldieck C, Seliger B. VHL-dependent alterations in the secretome of renal cell carcinoma: Association with immune cell response? Oncotarget. 2015 Dec 22;6(41):43420-37. doi: 10.18632/oncotarget.5560. PubMed PMID: 26486078.

Fiedler M, Rossmanith W, Wahle E, Rammelt C. Mitochondrial poly(A) polymerase is involved in tRNA repair. Nucleic Acids Res. 2015 Nov 16;43(20):9937-49. doi: 10.1093/nar/gkv891. Epub 2015 Sep 9. PubMed PMID: 26354863.

Sun Y, Bell JL, Carter DR, Gherardi S, Poulos RC, Milazzo G, Wong JW, Al-Awar R, Tee AE, Liu PY, Liu B, Atmadibrata B, Wong M, Trahair T, Zhao Q, Shohet JM, Haupt Y, Schulte JH, Brown PJ, Arrowsmith CH, Vedadi M, MacKenzie KL, Huttelmaier S, Perini G, Marshall GM, Braithwaite A, Liu T. WDR5 supports an N-Myc transcriptional complex that drives a pro-tumorigenic gene expression signature in neuroblastoma. Cancer Res. 2015 Oct 15. pii: canres.0423.2015. [Epub ahead of print] PubMed PMID: 26471359.

Köhn M, Ihling C, Sinz A, Krohn K, Hüttelmaier S. The Y3** ncRNA promotes the 3' end processing of histone mRNAs. Genes Dev. 2015 Oct 1;29(19):1998-2003. doi: 10.1101/gad.266486.115. PubMed PMID: 26443846; PubMed Central PMCID: PMC4604341.

Elbaum-Garfinkle S, Kim Y, Szczepaniak K, Chen CC, Eckmann CR, Myong S, Brangwynne CP. The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7189-94. doi: 10.1073/pnas.1504822112. Epub 2015 May 26. PubMed PMID: 26015579; PubMed Central PMCID: PMC4466716.

Nousch MEckmann CR. Translational activation maintains germline tissue homeostasis during adulthood. Worm. 2015 Jun 2;4(3):e1042644. doi: 10.1080/21624054.2015.1042644. eCollection 2015 Jul-Sep. PubMed PMID: 26430565; PubMed Central PMCID: PMC4588557.

Leisz S, Schulz K, Erb S, Oefner P, Dettmer K, Mougiakakos D, Wang E, Marincola FM, Stehle F, Seliger B. Distinct von Hippel-Lindau gene and hypoxia-regulated alterations in gene and protein expression patterns of renal cell carcinoma and their effects on metabolism. Oncotarget. 2015 May 10;6(13):11395-406. PubMed PMID: 25890500; PubMed Central PMCID: PMC4484464.

Jasinski-Bergner S, Stoehr C, Bukur J, Massa C, Braun J, Hüttelmaier S, Spath V, Wartenberg R, Legal W, Taubert H, Wach S, Wullich B, Hartmann A, Seliger B. Clinical relevance of miR-mediated HLA-G regulation and the associated immune cell infiltration in renal cell carcinoma. Oncoimmunology. 2015 Mar 2;4(6):e1008805. eCollection 2015 Jun. PubMed PMID: 26155421; PubMed Central PMCID: PMC4485830.

Bell JLTurlapati R, Liu T, Schulte JH, Hüttelmaier S. IGF2BP1 Harbors Prognostic Significance by Gene Gain and Diverse Expression in Neuroblastoma. J Clin Oncol. 2015 Mar 9. pii: JCO.2014.55.9880. [Epub ahead of print] PubMed PMID:25753434. 

Bley N, Lederer M, Pfalz B, Reinke C, Fuchs T, Glaß M, Möller B, Hüttelmaier S. Stress granules are dispensable for mRNA stabilization during cellular stress. Nucleic Acids Res. 2015 Feb 27;43(4):e26. doi: 10.1093/nar/gku1275. Epub 2014 Dec 8. PubMed PMID: 25488811; PubMed Central PMCID: PMC4344486.

Götze M, Pettelkau J, Fritzsche R, Ihling CH, Schäfer M, Sinz A. Automated assignment of MS/MS cleavable cross-links in protein 3D-structure analysis. J Am Soc Mass Spectrom. 2015 Jan;26(1):83-97. doi: 10.1007/s13361-014-1001-1. Epub 2014 Sep 27. PubMed PMID: 25261217.

Lederer M, Bley N, Schleifer C, Hüttelmaier S. The role of the oncofetal IGF2 mRNA-binding protein 3 (IGF2BP3) in cancer. Semin Cancer Biol. 2014 Dec;29:3-12. doi: 10.1016/j.semcancer.2014.07.006. Epub 2014 Jul 25. Review. PubMed PMID: 25068994.

Renner I, Funk N, Geissler R, Friedrich S, Penzel A, Behrens SE. Antiviral interferon-beta signaling induced by designed transcription activator-like effectors (TALE). PLoS One. 2014 Dec 3;9(12):e114288. doi: 10.1371/journal.pone.0114288. eCollection 2014. PubMed PMID: 25470486; PubMed Central PMCID: PMC4255017.

Schreier B, Rabe S, Winter S, Ruhs S, Mildenberger S, Schneider B, Sibilia M, Gotthardt M, Kempe S, Mäder K, Grossmann CGekle M. Moderate inappropriately high aldosterone/NaCl constellation in mice: cardiovascular effects and the role of cardiovascular epidermal growth factor receptor. Sci Rep. 2014 Dec 11;4:7430. doi: 10.1038/srep07430. PubMed PMID: 25503263; PubMed Central PMCID: PMC4262830.

Schönemann L, Kühn U, Martin G, Schäfer P, Gruber AR, Keller W, Zavolan M, Wahle E. Reconstitution of CPSF active in polyadenylation: recognition of the polyadenylation signal by WDR33. Genes Dev. 2014 Nov 1;28(21):2381-93. doi: 10.1101/gad.250985.114. Epub 2014 Oct 9. PubMed PMID: 25301781; PubMed Central PMCID: PMC4215183.

Jasinski-Bergner S, Stehle F, Gonschorek E, Kalich J, Schulz K, Huettelmaier S, Braun J, Seliger B. Identification of 14-3-3β gene as a novel miR-152 target using a proteome-based approach. J Biol Chem. 2014 Nov 7;289(45):31121-35. doi: 10.1074/jbc.M114.556290. Epub 2014 Sep 16. PubMed PMID: 25228695; PubMed Central PMCID: PMC4223316.

Friedrich S, Schmidt T, Geissler R, Lilie H, Chabierski S, Ulbert S, Liebert UG, Golbik RP, Behrens SE. AUF1 p45 promotes West Nile virus replication by an RNA chaperone activity that supports cyclization of the viral genome. J Virol. 2014 Oct;88(19):11586-99. doi: 10.1128/JVI.01283-14. Epub 2014 Jul 30. PubMed PMID: 25078689; PubMed Central PMCID: PMC4178777.

Nousch M, Yeroslaviz A, Habermann B, Eckmann CR. The cytoplasmic poly(A) polymerases GLD-2 and GLD-4 promote general gene expression via distinct mechanisms. Nucleic Acids Res. 2014 Oct;42(18):11622-33. doi: 10.1093/nar/gku838. Epub 2014 Sep 12. PubMed PMID: 25217583; PubMed Central PMCID: PMC4191412.

Jasinski-Bergner S, Mandelboim O, Seliger B. The role of microRNAs in the control of innate immune response in cancer. J Natl Cancer Inst. 2014 Sep 12;106(10). pii: dju257. doi: 10.1093/jnci/dju257. Print 2014 Oct. Review. PubMed PMID: 25217579.

Millonigg S, Minasaki RNousch MEckmann CR. GLD-4-mediated translational activation regulates the size of the proliferative germ cell pool in the adult C. elegans germ line. PLoS Genet. 2014 Sep 25;10(9):e1004647. doi: 10.1371/journal.pgen.1004647. eCollection 2014 Sep. PubMed PMID: 25254367; PubMed Central PMCID: PMC4177745.

Liu PY, Erriquez D, Marshall GM, Tee AE, Polly P, Wong M, Liu B, Bell JL, Zhang XD, Milazzo G, Cheung BB, Fox A, Swarbrick A, Hüttelmaier S, Kavallaris M, Perini G, Mattick JS, Dinger ME, Liu T. Effects of a novel long noncoding RNA, lncUSMycN, on N-Myc expression and neuroblastoma progression. J Natl Cancer Inst. 2014 Jun 6;106(7). pii: dju113. doi: 10.1093/jnci/dju113. Print 2014 Jul. Erratum in: J Natl Cancer Inst. 2015 Jan;107(1):doi/10.1093/jnci/dju359. PubMed PMID: 24906397.

Abendroth U, Schmidtke CBonas U. Small non-coding RNAs in plant-pathogenic Xanthomonas spp. RNA Biol. 2014;11(5):457-63. Epub 2014 Feb 27. Review. PubMed PMID: 24667380; PubMed Central PMCID: PMC4152354.

Quandt D, Jasinski-Bergner S, Müller U, Schulze B, Seliger B. Synergistic effects of IL-4 and TNFα on the induction of B7-H1 in renal cell carcinoma cells inhibiting allogeneic T cell proliferation. J Transl Med. 2014 May 30;12:151. doi: 10.1186/1479-5876-12-151. PubMed PMID: 24885059; PubMed Central PMCID: PMC4079621.

Gutschner T, Hämmerle M, Pazaitis NBley N, Fiskin E, Uckelmann H, Heim A, Groβ M, Hofmann N, Geffers R, Skawran B, Longerich T, Breuhahn K, Schirmacher P, Mühleck B, Hüttelmaier S, Diederichs S. Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an important protumorigenic factor in hepatocellular carcinoma. Hepatology. 2014 May;59(5):1900-11. doi: 10.1002/hep.26997. Epub 2014 Apr 1. PubMed PMID: 24395596.

Braun J, Misiak D, Busch B, Krohn K, Hüttelmaier S. Rapid identification of regulatory microRNAs by miTRAP (miRNA trapping by RNA in vitro affinity purification). Nucleic Acids Res. 2014 Apr 1;42(8):e66. doi: 10.1093/nar/gku127. Epub 2014 Feb 7. PubMed PMID: 24510096; PubMed Central PMCID: PMC4005655.

Misiak D, Posch S, Lederer M, Reinke C, Hüttelmaier S, Möller B. Extraction of protein profiles from primary neurons using active contour models and wavelets. J Neurosci Methods. 2014 Mar 30;225:1-12. doi: 10.1016/j.jneumeth.2013.12.009. Epub 2014 Jan 20. PubMed PMID: 24457055.

Monecke T, Buschmann J, Neumann P, Wahle E, Ficner R. Crystal structures of the novel cytosolic 5'-nucleotidase IIIB explain its preference for m7GMP. PLoS One. 2014 Mar 6;9(3):e90915. doi: 10.1371/journal.pone.0090915. eCollection 2014. PubMed PMID: 24603684; PubMed Central PMCID: PMC3946280.

Schreier BGekle MGrossmann C. Role of epidermal growth factor receptor in vascular structure and function. Curr Opin Nephrol Hypertens. 2014 Mar;23(2):113-21. doi: 10.1097/01.mnh.0000441152.62943.29. Review. PubMed PMID: 24401788.

Götze MWahle E. Smaug destroys a huge treasure. Genome Biol. 2014 Jan 27;15(1):101. doi: 10.1186/gb4156. PubMed PMID: 24468051; PubMed Central PMCID: PMC4054708.

Maldonado-Bonilla LD, Eschen-Lippold L, Gago-Zachert S, Tabassum N, Bauer N, Scheel D, Lee J. The Arabidopsis Tandem Zinc Finger 9 Protein binds RNA and Mediates Pathogen-Associated Molecular Pattern-Triggered Immune Responses. Plant Cell Physiol. 2013 Nov 27. [Epub ahead of print] PubMed PMID: 24285750.

Bell JL, Wächter K, Mühleck B, Pazaitis N, Köhn M, Lederer M, Hüttelmaier S. Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression? Cell Mol Life Sci. 2013 Aug;70(15):2657-75. doi: 10.1007/s00018-012-1186-z. Epub 2012 Oct 16. Review. PubMed PMID: 23069990; PubMed Central PMCID: PMC3708292. 

Zirkel A, Lederer M, Stöhr NPazaitis NHüttelmaier S. IGF2BP1 promotes mesenchymal cell properties and migration of tumor-derived cells by enhancing the expression of LEF1 and SNAI2 (SLUG). Nucleic Acids Res. 2013 May 15. [Epub ahea of print] PubMed PMID: 23677615.

Wächter K, Köhn M, Stöhr NHüttelmaier S. Subcellular localization and RNP
formation of IGF2BPs (IGF2 mRNA binding proteins) is modulated by distinct
RNA-binding domains. Biol Chem. 2013 May 1. doi:10.1515/hsz-2013-0111.
[Epub ahead of print] PubMed PMID: 23640942

Köhn M, Pazaitis NHüttelmaier S. Why YRNAs? About Versatile RNAs and Their Functions. Biomolecules. 2013 Feb 8;3(1):143-56. doi: 10.3390/biom3010143. PubMed PMID: 24970161; PubMed Central PMCID: PMC4030889.

Wolf A, Rietscher K, Glaß M, Hüttelmaier S, Schutkowski M, Ihling C, Sinz A, Wingenfeld A, Mun A, Hatzfeld M. Insulin signaling via Akt2 switches plakophilin 1 functions from stabilizing cell adhesion to promoting cell proliferation. J Cell Sci. 2013 Feb 26. [Epub ahead of print] PubMed PMID: 23444369.

Schreier B, Rabe S, Schneider B, Bretschneider M, Rupp S, Ruhs S, Neumann J,
Rueckschloss U, Sibilia M, Gotthardt M, Grossmann CGekle M. Loss of Epidermal
Growth Factor Receptor in Vascular Smooth Muscle Cells and Cardiomyocytes Cause Arterial Hypotension and Cardiac Hypertrophy. Hypertension. 2012 Dec 17. [Epub
ahead of print] PubMed PMID: 23248150

Buschmann J, Moritz B, Jeske M, Lilie H, Schierhorn A, Wahle E. Identification
of Drosophila and human 7-methyl GMP-specific nucleotidases. J Biol Chem. 2012
Dec 5. [Epub ahead of print] PubMed PMID: 23223233 

Bell JL, Wächter K, Mühleck B, Pazaitis N, Köhn M, Lederer M, Hüttelmaier S. Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression? Cell Mol Life Sci. 2012 Oct 16. [Epub ahead of print] PubMed PMID: 23069990.

Stöhr NHüttelmaier S. IGF2BP1: a post-transcriptional "driver" of tumor cell migration. Cell Adh Migr. 2012 Jul-Aug;6(4):312-8. doi: 10.4161/cam.20628. Epub 2012 Jul 1. PubMed PMID: 22983196; PubMed Central PMCID: PMC3478252.

Berndt H, Harnisch C, Rammelt CStöhr NZirkel A, Dohm JC, Himmelbauer H,Tavanez JP, Hüttelmaier SWahle E. Maturation of mammalian H/ACA box snoRNAs: PAPD5-dependent adenylation and PARN-dependent trimming. RNA. 2012 May;18(5):958-72. Epub 2012 Mar 22. PMID: 22442037  [PubMed - as supplied by publisher]

Stöhr N, Köhn M, Lederer M, Glaß M, Reinke C, Singer RH, Hüttelmaier S. IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling. Genes Dev. 2012 Jan 15;26(2):176-189. PubMed PMID: 22279049.

Schmidtke C, Findeiß S, Sharma CM, Kuhfuß J, Hoffmann S, Vogel J, Stadler PF, Bonas U. Genome-wide transcriptome analysis of the plant pathogen Xanthomonas identifies sRNAs with putative virulence functions. Nucleic Acids Res. 2011 Nov 12. PubMed PMID: 22080557.

Götze M, Pettelkau J, Schaks S, Bosse K, Ihling CH, Krauth F, Fritzsche R, Kühn U, Sinz A. StavroX-A Software for Analyzing Crosslinked Products in Protein Interaction Studies. J Am Soc Mass Spectrom. 2011 Oct 25. PubMed PMID: 22038510.

Braun JHüttelmaier S. Pathogenic mechanisms of deregulated microRNA expression in thyroid carcinomas of follicular origin. Thyroid Research. 2011 August 3; vol. 4. PubMed PMID: 21835047; PubMed Central PMCID: PMC3155107.

Danckwardt S, Gantzert AS, Macher-Goeppinger S, Probst HC, Gentzel M, Wilm M, Gröne HJ, Schirmacher P, Hentze MW, Kulozik AE. p38 MAPK controls prothrombin expression by regulated RNA 3' end processing. Mol Cell. 2011 Feb 4;41(3):298-310. PubMed PMID: 21292162.

Braun J, Hoang-Vu C, Dralle H, Hüttelmaier S. Downregulation of microRNAs directs the EMT and invasive potential of anaplastic thyroid carcinomas. Oncogene. 2010 Jul 22;29(29):4237-44. Epub 2010 May 24. PubMed PMID: 20498632.

Pulikkan JA, Dengler V, Peramangalam PS, Peer Zada AA, Müller-Tidow C, Bohlander SK, Tenen DG, Behre G. Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia. Blood. 2010 Mar 4;115(9):1768-78. Epub 2009 Dec 22. PubMed PMID: 20029046; PubMed Central PMCID: PMC2832809.