Regulation of RNA stability plays an important role in the regulation of gene expression. The first and often rate limiting step in mRNA decay is the removal of the poly(A)tail.
The poly(A)-specific ribonuclease (PARN) is an enzyme that catalyzes the removal of the poly(A)tail in vitro and can probably influence gene expression posttranscriptionally. But not much is known about the in vivo function of PARN in mammalian cells.
Using microarray analysis we could identify several potential PARN substrates and now I’m going to clarify the role of this enzyme in mammalian cells.
Supervisor: Prof. Wahle
Phone: +49-(0)-345-552 4951