2022
Thrum S, Sommer M, Raulien N, Gericke M, Massier L, Kovacs P, Krasselt M, Landgraf K, Körner A, Dietrich A, Blüher M, Rossol M, Wagner U. (2022) Macrophages in obesity are characterised by increased IL-1β response to calcium-sensing receptor signals. Int J Obes. doi: 10.1038/s41366-022-01135-x. Online ahead of print.
2021
Ackermann J, Arndt L, Kirstein M, Hobusch C, Brinker G, Klöting N, Braune J, Gericke M. (2021) Myeloid Cell-Specific IL-4 Receptor Knockout Partially Protects from Adipose Tissue Inflammation. J Immunol. 207(12):3081-3089. doi: 10.4049/jimmunol.2100699.
Baum P, Koj S, Klöting N, Blüher M, Classen J, Paeschke S, Gericke M, Toyka KV, Nowicki M, Kosacka J. (2021) Treatment-Induced Neuropathy in Diabetes (TIND)-Developing a Disease Model in Type 1 Diabetic Rats.Int J Mol Sci. 22(4):1571. doi: 10.3390/ijms22041571
Braune J, Lindhorst A, Fröba J, Hobusch C, Kovacs P, Blüher M, Eilers J, Bechmann I, Gericke M. (2021) Multinucleated Giant Cells in Adipose Tissue are Specialized in Adipocyte Degradation. Diabetes. 70(2):538-548. doi:10.2337/db20-0293
Brinker G, Froeba J, Arndt L, Braune J, Hobusch C, Lindhorst A, Bechmann I, Gericke M. (2021) CD4+ T cells regulate glucose homeostasis independent of adipose tissue dysfunction in mice. Eur J Immunol. 51(6):1399-1411. doi: 10.1002/eji.202048870
Krieg L*, Didt K*, Karkossa I, Bernhart SH, Kehr S, Subramanian N, Lindhorst A, Schaudinn A, Tabei S, Keller M, Stumvoll M, Dietrich A, von Bergen M, Stadler PF, Laurencikiene J, Krüger M, Blüher M, Gericke M, Schubert K, Kovacs P, Chakaroun R, Massier L. (2021) Multiomics reveal unique signatures of human epiploic adipose tissue related to systemic insulin resistance. Gut. doi: 10.1136/gutjnl-2021-324603. *These authors have contributed equally to this work. Online ahead of print.
Kunath A, Weiner J, Krause K, Rehders M, Pejkovska A, Gericke M, Biniossek ML, Dommel S, Kern M, Ribas-Latre A, Schilling O, Brix K, Stumvoll M, Klöting N, Heiker JT, Blüher M. (2021) Role of Kallikrein 7 in Body Weight and Fat Mass Regulation. Biomedicines. 9(2):131. doi: 10.3390/biomedicines9020131
Lindhorst A, Raulien N, Wieghofer P, Eilers J, Rossi FMV, Bechmann I, Gericke M. (2021) Adipocyte death triggers a pro-inflammatory response and induces metabolic activation of resident macrophages. Cell Death Dis. 12(6):579. doi: 10.1038/s41419-021-03872-9
Schaedlich K, Beier LS, Kolbe J, Wabitsch M, Ernst E. (2021) Pro-inflammatory effects of DEHP in SGBS-derived adipocytes and THP-1 macrophages. Sci Rep. 11:7928. doi: 10.1038/s41598-021-85119-3
2020
Dommel S, Berger C, Kunath A, Kern M, Gericke M, Kovacs P, Guiu-Jurado E, Klöting N, Blüher M. (2020) The Fabp4-Cre-Model is Insufficient to Study Hoxc9 Function in Adipose Tissue. Biomedicines. 8(7):184. doi:10.3390/biomedicines8070184
Ernst J, Gert K, Kraus FB, Rolle-Kampczyk UE, Wabitsch M, Dehghani F, Schaedlich K. (2020) Androstenedione changes stereoidogenic activity of SGBS cells. Endocr Connect. 9(7):587-598. doi:10.1530/EC-19-0549
Ernst J, Grabiec U, Falk K, Dehghani F, Schaedlich K. (2020) The endocrine disruptor DEHP and the ECS: analysis of a possible crosstalk. Endocr Connect. 9(2):101-110. doi:10.1530/EC-19-0548
Fahr L, Sunami Y, Maeritz N, Steiger K, Grünewald TGP, Gericke M, Kong B, Raulefs S, Mayerle J, Michalski CW, Regel I, Kleeff J (2020) Expression of the EWSR1-FLI1 fusion oncogene in pancreas cells drives pancreatic atrophy and lipomatosis. Pancreatology. 20(8):1673-1681. doi:10.1016/j.pan.2020.10.033
Landgraf K, Klöting N, Gericke M, Maixner N, Guiu-Jurado E, Scholz M, Witte AV, Beyer F, Schwartze JT, Lacher M, Villringer A, Kovacs P, Rudich A, Blüher M, Kiess W, Körner A (2020) The Obesity-Susceptibility Gene TMEM18 Promotes Adipogenesis through Activation of PPARG. Cell Rep. 33(3):108295. doi:10.1016/j.celrep.2020.108295
Lindhorst A, Bechmann I, Gericke M. (2020) Unspecific DNA recombination in AdipoqCre-ERT2 – mediated knockout approaches in transgenic mice is sex-, age- and genotype-dependent. Adipocyte. 9(1):1-6. doi:10.1080/21623945.2019.1701394
Massier L, Chakaroun R, Tabei S, Crane A, Didt KD, Fallmann J, von Bergen M, Haange SB, Heyne H, Stumvoll M, Gericke M, Dietrich A, Blüher M, Musat N, Kovacs P. (2020) Adipose tissue derived bacteria are associated with inflammation in obesity and type 2 diabetes. Gut. 69(10):1796-1806. doi:10.1136/gutjnl-2019-320118
Schleinitz D, Krause K, Wohland T, Gebhardt C, Linder N, Stumvoll M, Blüher M, Bechmann I, Kovacs P, Gericke M*, Tönjes A*. (2020) Identification of distinct transcriptome signatures of human adipose tissue from fifteen depots. Eur J Hum Genet. 28(12):1714-1725. doi:10.1038/s41431-020-0681-1. *These authors contributed equally to this work
Schopow N, Kallendrusch S, Gong S, Rapp F, Körfer J, Gericke M, Spindler N, Josten C, Langer S, Bechmann I. (2020) Examination of Ex-Vivo Viability of Human Adipose Tissue Slice Culture. PLoS One. 15(5):e0233152. doi:10.1371/journal.pone.0233152
Suchý T, Zieschang C, Popkova Y, Kaczmarek I, Weiner J, Liebing AD, Çakir MV, Landgraf K, Gericke M, Pospisilik JA, Körner A, Heiker JT, Dannenberger D, Schiller J, Schöneberg T, Liebscher I, Thor D. (2020) The repertoire of Adhesion G protein-coupled receptors in adipocytes and their functional relevance. Int J Obes (Lond). 44(10):2124-2136. doi:10.1038/s41366-020-0570-2
2019
Hadadi-Bechor S, Haim Y, Pecht T, Gat R, Tarnovscki T, Gericke M, Rudich A. (2019) Autophagy differentially regulates macrophage lipid handling depending on the lipid substrate (oleic acid vs. acetylated-LDL) and inflammatory activation state. Biochim Biophys Acta Mol Cell Biol Lipids. 1864(12):158527. doi:10.1016/j.bbalip.2019.158527
Hoffmann A, Ebert T, Klöting N, Kolb M, Gericke M, Jeromin F, Jessnitzer B, Lössner U, Burkhardt R, Stumvoll M, Fasshauer M, Kralisch S. (2019) Leptin decreases circulating inflammatory IL-6 and MCP-1 in mice. BioFactors. 45(1):43-48. doi:10.1002/biof.1457
Nyavor Y, Estill R, Edwards H, Ogden H, Heideman K, Starks K, Miller C, May G, Flesch L, McMillan J, Gericke M, Forney L, Balemba O. (2019) Intestinal nerve cell injury occurs prior to insulin resistance in female mice ingesting a high-fat diet. Cell Tissue Res. 376(3):325-340. doi:10.1007/s00441-019-03002-0
Schedlbauer C, Blaue D, Gericke M, Blüher M, Starzonek J, Gittel C, Brehm W, Vervuert I.(2019) Impact of body weight gain on hepatic metabolism and hepatic inflammatory cytokines in comparison of Shetland pony geldings and Warmblood horse geldings. PeerJ. 7:e7069. doi:10.7717/peerj.7069
Winkler S, Hempel M, Hsu MJ, Gericke M, Kühne H, Brückner S, Erler S, Burkhardt R, Christ B. (2019) Immune-Deficient Pfp/Rag2-/- Mice Featured Higher Adipose Tissue Mass and Liver Lipid Accumulation with Growing Age than Wildtype C57BL/6N Mice. Cells. 8(8):775. doi:10.3390/cells8080775
2018
Arndt L, Dokas J, Gericke M, Müller S, Thiery J, Burkhardt R. (2018) Tribbles homolog 1 deficiency modulates function and polarization of murine bone marrow-derived macrophages. J Biol Chem. 293(29):11527-11536. doi:10.1074/jbc.RA117.000703
Haimon Z, Volaski A, Orthgiess J, Boura-Halfon S, Varol D, Shemer A, Yona S, Zuckerman B, David E, Chappell-Maor L, Bechmann I, Gericke M, Ulitsky I, Jung S. (2018) Re-evaluating microglia expression profiles using RiboTag and cell isolation strategies. Nat Immunol. 19(6):636-644. doi:10.1038/s41590-018-0110-6
Schaedlich K, Gebauer S, Hunger L, Beier LS, Koch HM, Wabitsch M, Fischer B, Ernst J. (2018) DEHP deregulates adipokine levels and impairs fatty acid storage in human SGBS-adipocytes. Sci Rep. 8(1):3447. doi:10.1038/s41598-018-21800-4
Zieger K, Weiner J, Kunath A, Gericke M, Krause K, Kern M, Stumvoll M, Klöting N, Blüher M, Heiker JT. (2018) Ablation of kallikrein 7 (KLK7) in adipose tissue ameliorates metabolic consequences of high fat diet-induced obesity by counteracting adipose tissue inflammation in vivo. Cell Mol Life Sci. 75(4):727-742. doi:10.1007/s00018-017-2658-y
2017
Bechor S, Nachmias D, Elia N, Haim Y, Vatarescu M, Leikin-Frenkel A, Gericke M, Tarnovscki T, Las G, Rudich A. (2017) Adipose tissue conditioned media support macrophage lipid-droplet biogenesis by interfering with autophagic flux. Biochim Biophys Acta. 1862(9):1001-1012. doi:10.1016/j.bbalip.2017.06.012
Braune J, Weyer U, Matz-Soja M, Hobusch C, Kern M, Kunath A, Klöting N, Kralisch S, Blüher M, Gebhardt R, Zavros Y, Bechmann I, Gericke M. (2017) Hedgehog signaling in macrophages impacts on body weight, adipose tissue inflammation and glucose metabolism. Diabetologia. 60(5):889-899. doi:10.1007/s00125-017-4223-5
Braune J, Weyer U, Hobusch C, Mauer J, Brüning JC, Bechmann I, Gericke M. (2017) IL-6 regulates local proliferation of adipose tissue macrophages in obesity via up-regulation of the IL-4 receptor alpha. J Immunol. 198(7):2927-2934. doi:10.4049/jimmunol.1600476
Hesselbarth N, Kunath A, Kern M, Gericke M, Mejhert N, Ryden M, Stumvoll M, Blüher M, Klöting N. (2017) Repin1 deficiency in adipose tissue improves whole-body insulin sensitivity and lipid metabolism. Int J Obesity. 41(12):1815-1823. doi:10.1038/ijo.2017.172
2016
Ernst J, Grabiec U, Greither T, Fischer B, Dehghani F. (2016) The endocannabinoid system in the human granulosa cell line KGN. Mol Cell Endocrinol. 423:67-76.
Fiandanese N, Borromeo V, Berrini A, Fischer B, Schaedlich K, Schmidt JS, Secchi C, Pocar P. (2016) Maternal exposure to a mixture of di(2-ethylhexyl) phthalate (DEHP) and polychlorinated biphenyls (PCBs) causes reproductive dysfunction in adult male mouse offspring. Reprod Toxicol. 65:123-132.
Kunath A, Gericke M, Kern M, Dommel S, Hesselbarth N, Kovacs P, Stumvoll M, Blüher M, Klöting N. (2016) Repin1 deficiency improves insulin sensitivity and glucose metabolism in db/db mice by reducing adipose tissue mass and inflammation. Biochem Biophys Res Commun. 478(1):398-402.
Orthgiess J*, Gericke M*, Immig I, Schulz A, Hirrlinger J, Bechmann I, Eilers J. Neurons exhibit lyz2 promoter activity in vivo: implications for using LysM-Cre mouse in myeloid cell research. Eur J Immunol. (2016) 46(6):1529-1532. *These authors contributed equally to the article as first authors.
Stelzner K, Herbert D, Lorz A, Popkova Y, Schiller J, Gericke M, Blüher M, Simon JC, Saalbach A. (2016) Free fatty acids sensitize human monocyte derived dendritic cells for activation and favor a Th1/Th17 immune response. Eur J Immunol. 46(8):2043-2053.