Publikationen

Publications (last five years)

• Weber V, Olzscha H, Längrich T, Hartmann C, Jung M, Hofmann B, Horstkorte R, Bork K (2020):
   Glycation Increases the Risk of Microbial Traversal through an Endothelial Model of the Human Blood-Brain Barrier after Use of Anesthetics.
  J Clin Med. 9(11):3672

• Rosenstock P, Bork K, Massa C, Selke P, Seliger B, Horstkorte R (2020):
   Sialylation of Human Natural Killer (NK) Cells is Regulated by IL-2.
  J Clin Med. 9(6):1816

• Nagasundaram M, Horstkorte R, Gnanapragassam VS (2020):
   Sialic Acid Metabolic Engineering of Breast Cancer Cells Interferes with Adhesion and Migration.
  Molecules. 25(11):2632

• Scheer M, Bork K, Simon F, Nagasundaram M, Horstkorte R, Gnanapragassam VS (2020):
   Glycation Leads to Increased Polysialylation and Promotes the Metastatic Potential of Neuroblastoma Cells.
  Cells. 9(4):868

• Weber V, Bork K, Horstkorte R, Olzscha H (2020):
   Analyzing the Permeability of the Blood-Brain Barrier by Microbial Traversal through Microvascular Endothelial Cells.
  J Vis Exp. (156)

• Klaus C, Hansen JN, Ginolhac A, Gérard D, Gnanapragassam VS, Horstkorte R, Rossdam C, Buettner FFR, Sauter T, Sinkkonen L, Neumann H, Linnartz-Gerlach B (2020):
   Reduced sialylation triggers homeostatic synapse and neuronal loss in middle-aged mice.
  Neurobiol Aging. 88:91-107

• Simon F, Bork K, Gnanapragassam VS, Baldensperger T, Glomb MA, Di Sanzo S, Ori A, Horstkorte R (2019):
   Increased Expression of Immature Mannose-Containing Glycoproteins and Sialic Acid in Aged Mouse Brains.
  Int J Mol Sci. 20(24):6118

• Ye Z, Mittag S, Schmidt M, Simm A, Horstkorte R, Huber O (2019):
   Wnt Glycation Inhibits Canonical Signaling.
  Cells. 8(11):1320

• Bezold V, Rosenstock P, Scheffler J, Geyer H, Horstkorte R, Bork K (2019):
   Glycation of macrophages induces expression of pro-inflammatory cytokines and reduces phagocytic efficiency.
  Aging (Albany NY). 11(14):5258-5275

• Pogoryelova O, Urtizberea JA, Argov Z, Nishino I, Lochmüller H; ENMC workshop study group (2019):
   237th ENMC International Workshop: GNE myopathy - current and future research Hoofddorp, The Netherlands, 14-16 September 2018.
  Neuromuscul Disord. 29(5):401-410

• Rosenstock P, Bezold V, Bork K, Scheffler J, Horstkorte R (2019):
   Glycation interferes with natural killer cell function.
  Mech Ageing Dev. 178:64-71

• Scheffler J, Bork K, Bezold V, Rosenstock P, Gnanapragassam VS, Horstkorte R (2018):
   Ascorbic acid leads to glycation and interferes with neurite outgrowth.
  Exp Gerontol. 117:25-30

• Frank F, Bezold V, Bork K, Rosenstock P, Scheffler J, Horstkorte R (2019):
   Advanced glycation endproducts and polysialylation affect the turnover of the neural cell adhesion molecule (NCAM) and the receptor for advanced glycation endproducts (RAGE).
  Biol Chem. 400(2):219-226

• Volkers G, Lizak C, Niesser J, Rosell FI, Preidl J, Gnanapragassam VS, Horstkorte R, Rademann J, Strynadka NCJ (2018):
   Structural Basis for Binding of Fluorescent CMP-Neu5Ac Mimetics to Enzymes of the Human ST8Sia Family.
  ACS Chem Biol. 13(8):2320-2328

• Wratil PR, Horstkorte R (2017):
   Metabolic Glycoengineering of Sialic Acid Using N-acyl-modified Mannosamines.
  J Vis Exp. (129):55746

• Rosenstock P, Horstkorte R, Gnanapragassam VS, Harth J, Kielstein H (2017):
   Siglec-7 expression is reduced on a natural killer (NK) cell subset of obese humans.
  Immunol Res. 65(5):1017-1024

• Navarrete Santos A, Jacobs K, Simm A, Glaubitz N, Horstkorte R, Hofmann B (2017):
   Dicarbonyls induce senescence of human vascular endothelial cells.
  Mech Ageing Dev. 166:24-32

• Bork K, Weidemann W, Berneck B, Kuchta M, Bennmann D, Thate A, Huber O, Gnanapragassam VS, Horstkorte R (2017):
   The expression of sialyltransferases is regulated by the bioavailability and biosynthesis of sialic acids.
  Gene Expr Patterns. 23-24:52-58

• Goschzik T, Cremer H, Gnanapragassam VS, Horstkorte R, Bork K, Diestel S (2017):
   Mutation of a putative MAP kinase consensus site regulates NCAM endocytosis and NCAM-dependent neurite outgrowth.
  Neurosci Res. 120:28-35

• Kreuzmann D, Horstkorte R, Kohla G, Kannicht C, Bennmann D, Thate A, Bork K (2017):
   Increased Polysialylation of the Neural Cell Adhesion Molecule in a Transgenic Mouse Model of Sialuria.
  Chembiochem. 18(13):1188-1193

• Wratil PR, Horstkorte R, Reutter W (2016):
   Metabolic Glycoengineering with N-Acyl Side Chain Modified Mannosamines.
  Angew Chem Int Ed Engl. 55(33):9482-512

• Bennmann D, Weidemann W, Thate A, Kreuzmann D, Horstkorte R (2016):
   Aberrant O-GlcNAcylation disrupts GNE enzyme activity in GNE myopathy.
  FEBS J. 283(12):2285-94

• Hussain M, Bork K, Gnanapragassam VS, Bennmann D, Jacobs K, Navarette-Santos A, Hofmann B, Simm A, Danker K, Horstkorte R (2016):
   Novel insights in the dysfunction of human blood-brain barrier after glycation.
  Mech Ageing Dev. 155:48-54