The first lecture of the HAL-OX lecture series ‘Disease Biology and Molecular Medicine’ took place on 12th January 2015 in the grand ballroom of the Stadthaus located at Halle's main market square and was opened with greetings from the Lord Mayor of the City of Halle (Saale), Dr. Bernd Wiegand, and the Prime Minister of the State of Saxony-Anhalt, Dr. Reiner Haseloff. On this occasion, the english version of the image film of the city of Halle (Saale) also had its premiere. The guest of honor was Professor Eric O’Neill from the CRUK/MRC Institute for Radiation Oncology at the Old Road Campus in Oxford, who reported on recent research in genetic defects and their role in cancer development and therapy.