The inaugural lecture of the HAL-OX lecture series ‘Disease Biology and Molecular Medicine’ took place on 12th January 2015 in the Grand Ballroom of the Stadthaus at Halle’s Main Market Square and was opened with greetings from the Lord Mayor of Halle, Dr. Bernd Wiegand, and the State Prime Minister, Dr. Reiner Haseloff. The English version of the Halle image film also premiered on this occasion. The guest of honor was Prof. Eric O’Neill from the CRUK/MRC Institute for Radiation Oncology, located on Oxford’s Old Road Campus, who reported on recent research in genetic defects and their roles in cancer development and therapies.