Inflammatory cues as modulators of early pancreatic carcinogenesis (InCuPanC)

Chronic unresolved inflammation is considered as one of the most important risk factors for numerous malignancies including pancreatic cancer. In established pancreatic tumors, the impact of the inflammatory tumor microenvironment has been extensively studied during recent years. However, knowledge about the molecular circuits triggering inflammation-induced early pancreatic carcinogenesis is still very limited. Therefore, this RTG aims to systematically decipher the influence of different inflammatory cues induced by genetic, metabolic or exogenous triggers on the transition from preinvasive precursor lesions to invasive cancers during early pancreatic carcinogenesis.