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Stem cell transplantation

Scientific analysis of implemented blood stem cell transplantation

Besides the registration of recovery rates and side effects we are also analysing several influences on the clinical course after transplantation. Our main focus is on the influence of iron overload on the reconstruction of the immune system after transplantation as well as the identification of parameters predicting the therapy response of Graft versus Host diseases.

 

 http://web.uk-halle.de/fileadmin/Bereichsordner/Kliniken/InnereMedizin4/Fotos_Klinik/Session_11/DSC_6850.png

 

Transplantation of mesenchymal stem cells (MSC)

 

Mesenchymal stem cells can be isolated from many tissues of the human body. These cells seem to influence the regeneration of injured tissues as well as the regulation of the immune system. This knowledge offers various approaches for a therapeutic usage of these cells.

 

Selected publications of our working group

Keyszer G, Christopeit M, Fick S, Schendel M, Taute BM, Behre G, Müller LP, Schmoll HJ: Treatment of severe progressive systemic sclerosis with transplantation of mesenchymal stromal cells from allogeneic related donors: report of five cases. Arthritis Rheumatism 63 (8) (2011), 2540-2. 

Weber TGlaeser U, Christopeit M, Behre G. High pre-transplant ferritin is associated with low CD8 + count and infectious complications after allogeneic blood stem cell transplantation. Bone Marrow Transplant 45 (S2) (2010), P449 

Weber T, Theurich S, Christopeit M, Klapperstueck T, Behre G. Human herpesvirus-6 as an inducer of porphyria cutanea tarda: implications from a case. Transpl Infect Dis 12 (5) (2010), 432-6.

Jordan K, Wolf HH, Voigt W, Kegel T, Mueller LP, Behlendorf T, Sippel C, Arnold D, Schmoll HJ. Bevacizumab in combination with sequential high-dose chemotherapy in solid cancer, a feasibility study. Bone Marrow Transplant 45 (12) (2010), 1704-9. 

Keyßer G, Müller L, Schendel M, Schmoll, H-J Therapeutische Anwendung mesenchymaler Stromazellen bei Autoimmunerkrankungen - Rationale und erste klinische Erfahrungen. Zeitschrift für Rheumatologie 68 (2009), 220-227. 

Christopeit M, Schendel M, Föll J, Müller LP, Keysser G, Behre G: Marked improvement of severe progressive systemic sclerosis after transplantation of mesenchymal stem cells from an allogeneic haploidentical-related donor mediated by ligation of CD137L. Leukemia 22 (5) (2008), 1062-4.

Mueller LP, Theurich S, Christopeit M, Grothe W, Muetherig A, Weber T, Guenther S, Behre G: Neurotoxicity upon infusion of dimethylsulfoxide-cryopreserved peripheral blood stem cells in patients with and without preexisting cerebral disease. Eur J Haematol 78 (6) (2007) 527-31.

Muetherig AChristopeit MMueller LPGrothe WWeber TTheurich SBehre G: Human parvovirus B19 infection with GvHD-like erythema in two allogeneic stem cell transplant recipients. Bone Marrow Transplant 39 (5) (2007), 315-316. 

Voigt WKegel TMaher GJordan KMüller LSchmoll HJ: Bevacizumab plus high-dose ifosfamide, etoposide and carboplatin (HD-ICE) as third-line salvage chemotherapy induced an unexpected dramatic response in highly platinum refractory germ-cell cancer. Ann Oncol 17(3) (2006), 531-533. 

 

 

Contact

Prof. Dr. med.
Carsten Müller-Tidow
 

University Hospital Halle
Department of Inner Medicine IV
Hematology and Oncology
Ernst-Grube-Str. 40
D - 06120 Halle (Saale) 

Phone: +49 345 557 2924
Fax: +49 345 557 2950
E-Mail: innere4©uk-halle.de