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Publications

2018

Mensch A, Meinhardt B, Bley N, Hüttelmaier S, Schneider I, Stoltenburg-Didinger G, Kraya T, Müller T, Zierz S. The p.S85C-mutation in MATR3 impairs stress granule formation in Matrin-3 myopathy. Exp Neurol. 2018 Aug;306:222-231. 

Müller S, Bley N, Glaß M, Busch B, Rousseau V, Misiak D, Fuchs T, Lederer M, Hüttelmaier S. IGF2BP1 enhances an aggressive tumor cell phenotype by impairing miRNA-directed downregulation of oncogenic factors. Nucleic Acids Res. 2018 Jul 6;46(12):6285-6303. 

2017

Schneider M, Prudic K, Pippel A, Klapperstück M, Braam U, Müller CE, Schmalzing G, Markwardt F. Interaction of Purinergic P2X4 and P2X7 Receptor Subunits. Front Pharmacol. 2017 Nov 22;8:860.

2016

Wurth L, Papasaikas P, Olmeda D, Bley N, Calvo GT, Guerrero S, Cerezo-Wallis D, Martinez-Useros J, García-Fernández M, Hüttelmaier S, Soengas MS, Gebauer F. UNR/CSDE1 Drives a Post-transcriptional Program to Promote Melanoma Invasion and Metastasis. Cancer Cell. 2016 Nov 14;30(5):694-707. 

Möller B, Glaß M, Misiak D, Posch S. MiToBo - A Toolbox for Image Processing and Analysis. Journal of Open Research Software. 2016;4(1):e17. 

Keil R, Rietscher K, Hatzfeld M. Antagonistic Regulation of Intercellular Cohesion by Plakophilins 1 and 3. J Invest Dermatol. 2016 Oct;136(10):2022-9. 

Rietscher K, Wolf A, Hause G, Rother A, Keil R, Magin TM, Glass M, Niessen CM, Hatzfeld M. Growth retardation, loss of desmosomal adhesion and impaired tight junction function identify a unique role of plakophilin 1 in vivo. J Invest Dermatol. 2016 Mar 28. pii: S0022-202X(16)30984-8. 

Busch B, Bley N, Müller S, Glaß M, Misiak D, Lederer M, Vetter M, Strauß HG, Thomssen C, Hüttelmaier S. The oncogenic triangle of HMGA2, LIN28B and IGF2BP1 antagonizes tumor-suppressive actions of the let-7 family. Nucleic Acids Res. 2016 May 5;44(8):3845-64. 

Bretschneider M, Busch B, Mueller D, Nolze A, Schreier B, Gekle M, Grossmann C. Activated mineralocorticoid receptor regulates micro-RNA-29b in vascular smooth muscle cells. FASEB J. 2016 Jan 4. pii: fj.15-271254. 

2015

Köhn M, Ihling C, Sinz A, Krohn K, Hüttelmaier S. The Y3** ncRNA promotes the 3' end processing of histone mRNAs. Genes Dev. 2015 Oct 1;29(19):1998-2003. 

Bell JL, Turlapati R, Liu T, Schulte JH, Hüttelmaier S. IGF2BP1 harbors prognostic significance by gene gain and diverse expression in neuroblastoma. J Clin Oncol. 2015 Apr 10;33(11):1285-93. 

Bley N, Lederer M, Pfalz B, Reinke C, Fuchs T, Glaß M, Möller B, Hüttelmaier S. Stress granules are dispensable for mRNA stabilization during cellular stress. Nucleic Acids Res. 2015 Feb 27;43(4):e26. 

2014

Keil R, Hatzfeld M. The armadillo protein p0071 is involved in Rab11-dependent recycling. J Cell Sci. 2014 Jan 1;127(Pt 1):60-71. 

Lederer M, Bley N, Schleifer C, Hüttelmaier S. The role of the oncofetal IGF2 mRNA-binding protein 3 (IGF2BP3) in cancer. Semin Cancer Biol. 2014 Dec; 29:3-12.  

Riemann A, Schneider B, Gündel D, Stock C, Thews O, Gekle M. Acidic priming enhances metastatic potential of cancer cells. Pflügers Archiv: DOI 10.1007/s00424-014-1458-6 (2014)

Möller B, Piltz E, Bley N. Quantification of Actin Structures using Unsupervised Pattern Analysis Techniques. Proceedings International Conference on Pattern Recognition (ICPR), IEEE, pp. to appear, Stockholm, Sweden, August 2014. 

Misiak D, Posch S, Lederer M, Reinke C, Hüttelmaier S, Möller B. Extraction of protein profiles from primary neurons using active contour models and wavelets. Journal of Neuroscience Methods, Volume 225, 30 March 2014, Pages 1-12. pii: S0165-0270(13)00433-0. 

Gutschner T, Hämmerle M, Pazaitis N, Bley N, Fiskin E, Uckelmann H, Heim A, Groß M, Hofmann N, Geffers R, Skawran B, Longerich T, Breuhahn K, Schirmacher P, Mühleck B, Hüttelmaier S, Diederichs S. The Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an important pro-tumorigenic factor in hepatocellular carcinoma. Hepatology. 2014 Jan 7. 

2013

Zirkel A, Lederer M, Stöhr N, Pazaitis N, Hüttelmaier S. IGF2BP1 promotes mesenchymal cell properties and migration of tumor-derived cells by enhancing the expression of LEF1 and SNAI2 (SLUG). Nucleic Acids Res. 2013 May 15. 

Wächter K, Köhn M, Stöhr N, Hüttelmaier S. Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA binding proteins) is modulated by distinct RNA-binding domains. Biol Chem. 2013 May 1. doi:10.1515/hsz-2013-0111. 

Wolf A, Rietscher K, Glaß M, Hüttelmaier S, Schutkowski M, Ihling C, Sinz A, Wingenfeld A, Mun A, Hatzfeld M (2013). Insulin signaling via Akt2 switches plakophilin 1 function from stabilizing cell adhesion to promoting cell proliferation. J Cell Sci 126: 1832-1844.7

Köhn M, Pazaitis  N, Hüttelmaier, S. Why YRNAs? About Versatile RNAs and Their Functions. Biomolecules 2013, 3(1), 143-156. 2013 Feb 13. 

2012

Glaß M, Möller B, Zirkel A, Wächter K, Hüttelmaier S, Posch S. Cell migration analysis: Segmenting scratch assay images with level sets and support vector machines. Pattern Recognition, Volume 45, Issue 9, September 2012, Pages 3154-3165, ISSN 0031-3203, 10.1016/j.patcog.2012.03.00.

Seltmann K, Roth W, Kröger C, Loschke F, Lederer M, Hüttelmaier S, Magin TM. Keratins mediate localization of hemidesmosomes and repress cell motility. J Invest Dermatol. 2013 Jan;133(1):181-90. 

  Stöhr N, Hüttelmaier S. IGF2BP1: a post-transcriptional "driver" of tumor cell migration. Cell Adh Migr. 2012 Jul-Aug;6(4):312-8. 


Eiseler T, Koehler C, Nimmagadda SC, Jamali A, Funk N, Joodi G, Storz P, Seufferlein T. Protein Kinase D1 mediates anchorage-dependent and independent growth of tumor cells via the zinc-finger transcription factor Snail1. J Biol Chem. 2012 Jul 12. 

Ruhs S, Strätz N, Schlör K, Meinel S, Mildenberger S, Rabe S, Gekle M, Grossmann C. Modulation of transcriptional mineralocorticoid receptor activity by nitrosative stress. Free Radic Biol Med. 2012 Jun 26;53(5):1088-1100.

Grossmann C, Ruhs, S, Langenbruch, L, Mildenberger, S, Straetz, N, Schumann, K, Gekle, M. Nuclear Shuttling Precedes Dimerization in Mineralocorticoid Receptor Signaling. Chem Biol. 2012 Jun 22;19(6):742-51.

Seiferth A, Ruhs S, Mildenberger S, Gekle M, Grossmann C. The phosphatase calcineurin PP2BAβ mediates part of mineralocorticoid receptor transcriptional activity. FASEB J. 2012 Jun;26(6):2327-37.

Berndt H, Harnisch C, Rammelt C, Stöhr N, Zirkel A, Dohm JC, Himmelbauer H,Tavanez JP, Hüttelmaier S, Wahle E. Maturation of mammalian H/ACA box snoRNAs: PAPD5-dependent adenylation and PARN-dependent trimming. RNA. 2012 May;18(5):958-72. 

Busch T, Armacki M, Eiseler T, Joodi G, Temme C, Jansen J, von Wichert G, Omary MB, Spatz J, Seufferlein T. Keratin 8 phosphorylation regulates keratin reorganization and migration of epithelial tumor cells. J Cell Sci. 2012 May 1;125(Pt 9):2148-59. 

Stöhr N, Köhn M, Lederer M, Glaß M, Reinke C, Singer RH, Hüttelmaier S. IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling. Genes Dev. 2012 Jan 15;26(2):176-189. 

2011

Fronz K, Güttinger S, Burkert K, Kühn U, Stöhr N, Schierhorn A, Wahle E. Arginine methylation of the nuclear poly(A) binding protein weakens the interaction with its nuclear import receptor, transportin. J Biol Chem. 2011 Aug 1. 

Braun J, Hüttelmaier S. Pathogenic mechanisms of deregulated microRNA expression in thyroid carcinomas of follicular origin. Thyroid Research. 2011 August 3; vol. 4.

Glaß M, Möller B, Zirkel A, Wächter K, Hüttelmaier S, Posch S. Scratch assay analysis with topology-preserving level sets and texture measures. Proc. of 5th Iberian Conference on Pattern Recognition and Image Analysis (IbPRIA '11), pages 100-108, Gran Canaria, Spain, 2011

2010

Möller B, Stöhr N, Hüttelmaier S, Posch S. Cascaded Segmentation of Grained Cell Tissue with Active Contour Models. In Proc. of Int. Conf. on Pattern Recognition (ICPR), IEEE, pp. 1481-1484, Istanbul, Turkey, August 2010. 

Grossmann C, Husse B, Mildenberger S, Schreier B, Schuman K, Gekle M. Colocalization of mineralocorticoid and EGF receptor at the plasma membrane. Biochim Biophys Acta. 2010 May;1803(5):584-90.

Braun J, Hoang-Vu C, Dralle H, Hüttelmaier S. Downregulation of microRNAs directs the EMT and invasive potential of anaplastic thyroid carcinomas. Oncogene. 2010 May 24. 

Köhn M, Lederer M, Wächter K, Hüttelmaier S. Near-infrared (NIR) dye-labeled RNAs identify binding of ZBP1 to the noncoding Y3-RNA. RNA. 2010 Jul;16(7):1420-8.

Möller B, Greß O, Stöhr N, Hüttelmaier S, Posch S. Adaptive segmentation of cells and particles in fluorescent microscope images. In Proc. of International Conference on Computer Vision Theory and Applications (VISAPP '10), vol. 2, pp. 97-106, Angers, France, May 2010. 

Wolf A, Krause-Gruszczynska M, Birkenmeier O, Ostareck-Lederer A, Hüttelmaier S, Hatzfeld M. Plakophilin 1 stimulates translation by promoting eIF4A1 activity.J Cell Biol. 2010 Feb 22;188(4):463-71.