Dr. med. Thomas Weber

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Thomas Weber ist seit 2016 als Oberarzt an der Universitätsklinik für Innere Medizin IV tätig. Zu seinen klinischen Schwerpunkten gehören die Behandlung von Patienten mit Malignen Lymphomen und die Durchführung von klinischen Studien bei diesen Patienten. Aktuelle wissenschaftliche Schwerpunkte seiner Arbeit sind die Untersuchung der Relevanz genetischer Veränderungen als auch des Tumorstromas für die Vermittlung von Wachstum und Chemotherapieresistenz in T-Zell-Lymphomen.

  • Oberarzt
  • Leiter der Studienzentrale
  • Verantwortlichkeit Station Innere 10
  • Ambulante Spezialsprechstunde Maligne Lymphome
  • Leiter einer molekularbiologischen Arbeitsgruppe im Forschungslabor der Klinik
  • Lymphatische Neoplasien
  • Klinische Studien
  • Translationale Forschung zur Charakterisierung genetischer Aberrationen von T-Zell  Neoplasien
  • Molekulare Grundlagen primärer Chemotherapieresistenz von T-Zell Neoplasien 
  • Rolle des Tumorstromas für das Wachstum und Therapieresistenz bei Malignen Lymphomen
  • Seit November 2018 Ko-Sprecher der AG T-Zell Lymphome der GLA
  • 2016 Förderung durch das Clinical Scientist Program der Medizinischen Fakultät der MLU
  • 2013 Facharzt für Innere Medizin
  • seit 2005 Universitätsklinikum Halle (Saale), Klinik für Innere Medizin IV;  Promotion zum Dr. med. (Prädikat: summa cum laude), Technische Universität Dresden, Klinik für Urologie
  • 2005 Technische Universität Dresden, Klinik für Urologie
  • 1998 - 2005 Studium der Humanmedizin, Technische Universität Dresden und Vrije Universiteit Amsterdam, Niederlande

2020

Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19 Patients. Kreer C, Zehner M, Weber T, Ercanoglu MS, Gieselmann L, Rohde C, Halwe S, Korenkov M, Schommers P, Vanshylla K, Di Cristanziano V, Janicki H, Brinker R, Ashurov A, Krähling V, Kupke A, Cohen-Dvashi H, Koch M, Eckert JM, Lederer S, Pfeifer N, Wolf T, Vehreschild MJGT, Wendtner C, Diskin R, Gruell H, Becker S, Klein F.Kreer C, et al. Among authors: weber t. Cell. 2020 Sep 17;182(6):1663-1673. doi: 10.1016/j.cell.2020.08.046.Cell. 2020. PMID: 32946786

Structured Reporting of Solid and Cystic Pancreatic Lesions in CT and MRI: Consensus-Based Structured Report Templates of the German Society of Radiology (DRG). Persigehl T, Baumhauer M, Baeßler B, Beyer LP, Bludau M, Bruns C, Bunck AC, Germer CT, Grenacher L, Hackländer T, Haneder S, Heinrich S, Heusch P, Hoffmann M, Juchems MS, Kröger JR, Kotter E, Layer G, Maintz D, Menke J, Palmowski M, Pantelis D, Pinto Dos Santos D, Popp FC, Schäfer N, Schlemmer HP, Schreyer AG, Siedek F, Stippel D, Völker M, Waldschmidt DT, Weber TF, von Winterfeld M, Wybranski C, Zander T, Wessling J.Persigehl T, et al. Among authors: weber tf. Rofo. 2020 Jul;192(7):641-656. doi: 10.1055/a-1150-8217. Epub 2020 Jul 2.Rofo. 2020. PMID: 32615626

Impact of bone marrow involvement on outcome in relapsed and refractory transplant eligible diffuse large B-cell lymphoma and transformed indolent lymphoma. Terziev D, Bauer M, Paschold L, Wickenhauser C, Wienke A, Binder M, Müller LP, Weber T.Terziev D, et al. Among authors: weber t. PLoS One. 2020 Jul 8;15(7):e0235786. doi: 10.1371/journal.pone.0235786. eCollection 2020.PLoS One. 2020. PMID: 32639975

 

2018

Stringent vaccination of cancer patients: is it that important?, Weber T, Ljungman P.Weber T, et al. Ann Oncol. 2018 Jun  1;29(6):1348-1349. doi: 10.1093/annonc/mdy154.Ann Oncol. 2018. PMID: 29697738

Nivolumab maintenance after salvage autologous stem cell transplantation results in long-term remission in multiple relapsed primary CNS lymphoma. Terziev D, Hutter B, Klink B, Stenzinger A, Stögbauer F, Glimm H, Fröhling S, Wickenhauser C, Jordan K, Hurtz HJ, Müller LP, Rüssel J, Weber T.Terziev D, et al. Among authors: weber t. Eur J Haematol. 2018 Jul;101(1):115-118. doi: 10.1111/ejh.13072. Epub 2018 May 11.Eur J Haematol. 2018. PMID: 29624748

Diagnosis of invasive fungal diseases in haematology and oncology: 2018 update of the recommendations of the infectious diseases working party of the German society for hematology and medical oncology (AGIHO). Ruhnke M, Behre G, Buchheidt D, Christopeit M, Hamprecht A, Heinz W, Heussel CP, Horger M, Kurzai O, Karthaus M, Löffler J, Maschmeyer G, Penack O, Rieger C, Rickerts V, Ritter J, Schmidt-Hieber M, Schuelper N, Schwartz S, Ullmann A, Vehreschild JJ, von Lilienfeld-Toal M, Weber T, Wolf HH.Ruhnke M, et al. Among authors: weber t. Mycoses. 2018 Nov;61(11):796-813. doi: 10.1111/myc.12838. Epub 2018 Sep 3.Mycoses. 2018. PMID: 30098069

 

2017

Dose-Reduced Versus Standard Conditioning Followed by Allogeneic Stem-Cell Transplantation for Patients With Myelodysplastic Syndrome: A Prospective Randomized Phase III Study of the EBMT (RICMAC Trial). Kröger N, Iacobelli S, Franke GN, Platzbecker U, Uddin R, Hübel K, Scheid C, Weber T, Robin M, Stelljes M, Afanasyev B, Heim D, Deliliers GL, Onida F, Dreger P, Pini M, Guidi S, Volin L, Günther A, Bethge W, Poiré X, Kobbe G, van Os M, Brand R, de Witte T.Kröger N, et al. Among authors: weber t. J Clin Oncol. 2017 Jul 1;35(19):2157-2164. doi: 10.1200/JCO.2016.70.7349. Epub 2017 May 2.J Clin Oncol. 2017. PMID: 28463633

Epidemiology of invasive aspergillosis and azole resistance in patients with acute leukaemia: the SEPIA Study. Koehler P, Hamprecht A, Bader O, Bekeredjian-Ding I, Buchheidt D, Doelken G, Elias J, Haase G, Hahn-Ast C, Karthaus M, Kekulé A, Keller P, Kiehl M, Krause SW, Krämer C, Neumann S, Rohde H, La Rosée P, Ruhnke M, Schafhausen P, Schalk E, Schulz K, Schwartz S, Silling G, Staib P, Ullmann A, Vergoulidou M, Weber T, Cornely OA, Vehreschild MJ.Koehler P, et al. Among authors: weber t. Int J Antimicrob Agents. 2017 Feb;49(2):218-223. doi: 10.1016/j.ijantimicag.2016.10.019. Epub 2016 Dec 12.Int J Antimicrob Agents. 2017. PMID: 27989379

 

2016

Community acquired respiratory virus infections in cancer patients-Guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for haematology and Medical Oncology. von Lilienfeld-Toal M, Berger A, Christopeit M, Hentrich M, Heussel CP, Kalkreuth J, Klein M, Kochanek M, Penack O, Hauf E, Rieger C, Silling G, Vehreschild M, Weber T, Wolf HH, Lehners N, Schalk E, Mayer K.von Lilienfeld-Toal M, et al. Among authors: weber t. Eur J Cancer. 2016 Nov;67:200-212. doi: 10.1016/j.ejca.2016.08.015. Epub 2016 Sep 25.Eur J Cancer. 2016. PMID: 27681877

Influenza virus infections in patients with malignancies -- characteristics and outcome of the season 2014/15. A survey conducted by the Infectious Diseases Working Party (AGIHO) of the German Society of Haematology and Medical Oncology (DGHO). Hermann B, Lehners N, Brodhun M, Boden K, Hochhaus A, Kochanek M, Meckel K, Mayer K, Rachow T, Rieger C, Schalk E, Weber T, Schmeier-Jürchott A, Schlattmann P, Teschner D, von Lilienfeld-Toal M.Hermann B, et al. Among authors: weber t. Eur J Clin Microbiol Infect Dis. 2017 Mar;36(3):565-573. doi: 10.1007/s10096-016-2833-3. Epub 2016 Nov 12.Eur J Clin Microbiol Infect Dis. 2017. PMID: 27838792

Enteric-coated mycophenolate sodium containing GvHD prophylaxis reduces GvHD rate after allogeneic HSCT. Weber T, Niestadtkötter J, Wienke A, Müller-Tidow C, Müller LP.Weber T, et al. Eur J Haematol. 2016 Sep;97(3):232-8. doi: 10.1111/ejh.12710. Epub 2016 Jan 14.Eur J Haematol. 2016. PMID: 26613546

 

2014

Management of sepsis in neutropenic patients: 2014 updated guidelines from the Infectious Diseases Working Party of the German Society of Hematology and Medical Oncology (AGIHO). Penack O, Becker C, Buchheidt D, Christopeit M, Kiehl M, von Lilienfeld-Toal M, Hentrich M, Reinwald M, Salwender H, Schalk E, Schmidt-Hieber M, Weber T, Ostermann H.Penack O, et al. Among authors: weber t. Ann Hematol. 2014 Jul;93(7):1083-95. doi: 10.1007/s00277-014-2086-0. Epub 2014 Apr 29.Ann Hematol. 2014. PMID: 24777705

Stage-dependent prognostic impact of molecular signatures in clear cell renal cell carcinoma. Weber T, Meinhardt M, Zastrow S, Wienke A, Erdmann K, Hofmann J, Fuessel S, Wirth MP.Weber T, et al. Onco Targets Ther. 2014 May 2;7:645-54. doi: 10.2147/OTT.S59983. eCollection 2014.Onco Targets Ther. 2014. PMID: 24833908

Treatment of rare co-occurrence of Epstein-Barr virus-driven post-transplant lymphoproliferative disorder and hemophagocytic lymphohistiocytosis after allogeneic stem cell transplantation. Weber T, Wickenhauser C, Monecke A, Gläser C, Stadler M, Desole M, Ligeti K, Behrmann C, Müller-Tidow C, Müller LP.Weber T, et al. Transpl Infect Dis. 2014 Dec;16(6):988-92. doi: 10.1111/tid.12287. Epub 2014 Sep 1.Transpl Infect Dis. 2014. PMID: 25179757

 

2013

Cyclosporine area under the curve after allogeneic hematopoietic stem cell transplantation is an indicator of Epstein-Barr virus DNAemia. Christopeit M, Janssen N, Weber T, Bacher U, Lautenschläger C, Oehme A, Kekulé AS, Schmoll HJ.Christopeit M, et al. Among authors: weber t. Leuk Lymphoma. 2013 Jan;54(1):133-7. doi: 10.3109/10428194.2012.705001. Epub 2012 Sep 8.Leuk Lymphoma. 2013. PMID: 22721496

Right flank pain and high fever in a neutropenic patient with acute lymphoblastic leukaemia. Christopeit M, Lindner A, Surov A, Weber T, Vehreschild MJ, Bialek R, Schmoll HJ.Christopeit M, et al. Among authors: weber t. Mycoses. 2013 Jan;56(1):90-2. doi: 10.1111/j.1439-0507.2012.02231.x. Epub 2012 Aug 13.Mycoses. 2013. PMID: 22889321

Allogeneic hematopoietic stem cell transplantation: an option for long-term survival for patients with simultaneous appearance of myeloid and lymphatic malignancies. Weber T, Ocheni S, Binder M, Theurich S, Scheid C, Schmid C, Müller LP, Christopeit M, Bacher U.Weber T, et al. Acta Haematol. 2013;129(3):135-6. doi: 10.1159/000343422. Epub 2012 Nov 29.Acta Haematol. 2013. PMID: 23207834

Immunohistochemical analysis of prognostic protein markers for primary localized clear cell renal cell carcinoma. Weber T, Meinhardt M, Zastrow S, Wienke A, Fuessel S, Wirth MP.Weber T, et al. Cancer Invest. 2013 Jan;31(1):51-9. doi: 10.3109/07357907.2012.749267.Cancer Invest. 2013. PMID: 23327192

PARK2 and PACRG are commonly downregulated in clear-cell renal cell carcinoma and are associated with aggressive disease and poor clinical outcome. Toma MI, Wuttig D, Kaiser S, Herr A, Weber T, Zastrow S, Koch R, Meinhardt M, Baretton GB, Wirth MP, Fuessel S.Toma MI, et al. Among authors: weber t. Genes Chromosomes Cancer. 2013 Mar;52(3):265-73. doi: 10.1002/gcc.22026. Epub 2012 Nov 2.Genes Chromosomes Cancer. 2013. PMID: 23125027

 

2012

[Unexplained fever and B-symptoms in a young male Black African]. Weber T, Ettrich T, Christopeit M, Lindner A, Holzhausen HJ, Oehme A, Arnold D, Wolf HH, Lübbert C, Kekulé AS, Schmoll HJ, Werdan K, Ebelt H.Weber T, et al. Internist (Berl). 2012 Jan;53(1):93-8. doi: 10.1007/s00108-011-2912-6.Internist (Berl). 2012. PMID: 21953027

Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial. Calhoun WJ, Ameredes BT, King TS, Icitovic N, Bleecker ER, Castro M, Cherniack RM, Chinchilli VM, Craig T, Denlinger L, DiMango EA, Engle LL, Fahy JV, Grant JA, Israel E, Jarjour N, Kazani SD, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF, Lugogo N, Martin RJ, Meyers DA, Moore WC, Pascual R, Peters SP, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Wasserman SI, Walter MJ, Wechsler ME, Boushey HA; Asthma Clinical Research Network of the National Heart, Lung, and Blood Institute.Calhoun WJ, et al. JAMA. 2012 Sep 12;308(10):987-97. doi: 10.1001/2012.jama.10893.JAMA. 2012. PMID: 22968888

 

2011

Expression of the Forkhead transcription factor FOXP1 is associated with tumor grade and Ki67 expression in clear cell renal cell carcinoma. Toma MI, Weber T, Meinhardt M, Zastrow S, Grimm MO, Füssel S, Wirth MP, Baretton GB.Toma MI, et al. Among authors: weber t. Cancer Invest. 2011 Feb;29(2):123-9. doi: 10.3109/07357907.2010.535059. Epub 2011 Jan 6.Cancer Invest. 2011. PMID: 21210727

 

2010

Human herpesvirus-6 as an inducer of porphyria cutanea tarda: implications from a case. Weber T, Theurich S, Christopeit M, Klapperstueck T, Behre G.Weber T, et al. Transpl Infect Dis. 2010 Oct;12(5):432-6. doi: 10.1111/j.1399-3062.2010.00511.x.Transpl Infect Dis. 2010. PMID: 20487413

HBs seroconversion in a patient with acute hepatitis B treated with entecavir during immunosuppression against severe bronchiolitis obliterans in the course of chronic graft versus host disease. Christopeit M, Weber T, Abendroth J, Dollinger M, Lübbert C, Oehme A, Kekulé AS, Behre G.Christopeit M, et al. Among authors: weber t. J Clin Virol. 2010 Jul;48(3):218-9. doi: 10.1016/j.jcv.2010.03.009. Epub 2010 Apr 18.J Clin Virol. 2010. PMID: 20403727

 

2009

Rituximab reduces the incidence of acute graft-versus-host disease. Christopeit M, Schütte V, Theurich S, Weber T, Grothe W, Behre G.Christopeit M, et al. Among authors: weber t. Blood. 2009 Mar 26;113(13):3130-1. doi: 10.1182/blood-2009-01-200527.Blood. 2009. PMID: 19324911

Reply to 'The correlation between cotransplantation of mesenchymal stem cells and higher recurrence rates in hematologic malignancy patients: outcome of a pilot clinical study' by Ning et al. Behre G, Theurich S, Weber T, Christopeit M.Behre G, et al. Among authors: weber t. Leukemia. 2009 Jan;23(1):178; author reply 179-80. doi: 10.1038/leu.2008.150. Epub 2008 Jun 12.Leukemia. 2009. PMID: 18548101

Successful treatment of severe sinusoidal obstruction syndrome despite multiple organ failure with defibrotide after allogeneic stem cell transplantation: a case report. Behre G, Theurich S, Christopeit M, Weber T.Behre G, et al. Among authors: weber t. J Med Case Rep. 2009 Mar 10;3:6164. doi: 10.4076/1752-1947-3-6164.J Med Case Rep. 2009. PMID: 19830097

Successful treatment of Candida spp. encephalitis occurring under Caspofungin treatment after allogeneic stem cell transplantation. Behre G, Christopeit M, Weber T.Behre G, et al. Among authors: weber t. Ann Hematol. 2009 Jan;88(1):93-4. doi: 10.1007/s00277-008-0551-3. Epub 2008 Jul 31.Ann Hematol. 2009. PMID: 18668242

Graft-versus-lymphoma effect in a 64-year-old caucasian woman after allogeneic stem-cell transplantation: a case report. Behre G, Weber T, Theurich S, Christopeit M.Behre G, et al. Among authors: weber t. J Med Case Rep. 2009 Jan 13;3:10. doi: 10.1186/1752-1947-3-10.J Med Case Rep. 2009. PMID: 19144104

 

2008

Involved field radiation therapy and donor lymphocyte infusion for relapsed or refractory non-Hodgkin lymphoma after allogeneic hematopoietic stem cell transplantation. Behre G, Christopeit M, Weber T.Behre G, et al. Among authors: weber t. Int J Hematol. 2008 Nov;88(4):463-464. doi: 10.1007/s12185-008-0174-4. Epub 2008 Oct 4.Int J Hematol. 2008. PMID: 18836792

 

2007

Neurotoxicity upon infusion of dimethylsulfoxide-cryopreserved peripheral blood stem cells in patients with and without pre-existing cerebral disease. Mueller LP, Theurich S, Christopeit M, Grothe W, Muetherig A, Weber T, Guenther S, Behre G.Mueller LP, et al. Among authors: weber t. Eur J Haematol. 2007 Jun;78(6):527-31. doi: 10.1111/j.1600-0609.2007.00851.x.Eur J Haematol. 2007. PMID: 17509106

Human parvovirus B19 infection with GvHD-like erythema in two allogeneic stem cell transplant recipients. Muetherig A, Christopeit M, Müller LP, Grothe W, Weber T, Theurich S, Behre G.Muetherig A, et al. Among authors: weber t. Bone Marrow Transplant. 2007 Mar;39(5):315-6. doi: 10.1038/sj.bmt.1705589.Bone Marrow Transplant. 2007. PMID: 17311086