The regulation of selected antigen processing genes by microRNAs
In a variety of human tumors of distinct origin a down-regulation or complete loss of MHC class I surface expression was detected, which was associated with a reduced T cell-mediated lysis and poor prognosis of patients. The underlying molecular mechanisms of MHC class I abnormalities could be caused by the modulation and/or inhibition of the expression of APM components. Previous work often demonstrated a discordant mRNA and protein expression for the antigen processing components ERAP1, TAP1 and TAP2 in human tumors suggesting a posttranscriptional gene regulation of APM components. Therefore, the aim of the project is determine whether APM-specific microRNAs are involved in this process.
Supervisor: Prof. Seliger