Multivisceral Oncological Resections Involving the Pancreas - An International Multicenter Study
Objective
Complete resection is crucial for solid malignancies. Locally advanced cases may require multivisceral resection, introducing complexities and risks. This study addresses the impact of multivisceral oncological resections involving the pancreas on morbidity, mortality, and long-term survival across various tumor entities. The objective is to provide evidence-based recommendations and potentially establish an international study group.
Study Design
Retrospective multicenter study globally, analyzing elective multivisceral oncological resections involving the pancreas.
Inclusion and Exclusion Criteria
Consecutive patients from Jan 1, 2010, to Dec 31, 2022, undergoing elective multivisceral oncological resections involving the pancreas. Various patient and operation characteristics will be documented.
Objectives
Evaluate outcomes, determine factors associated with morbidity/mortality, overall survival, and disease-free survival.
Data Collection
Online survey for yearly case volumes and care standards. Online electronic case report form (REDCap®) for detailed data.
Ethics
Approval from the Ethics Committee of the University Hospital Halle (Saale), Germany was obtained.
Statistical Analysis
Exploratory study, appropriate statistical tests applied. Subgroup analyses for distinct tumor entities will be conducted.
Study Coordinator:
Artur Rebelo, MD, MHBA, FEBVS; Department of Visceral, Vascular and Endocrine Surgery, University Hospital Halle (Saale),
Principal Investigators:
Jörg Kleeff, MD, MHBA, FACS, FRCS; Department of Visceral, Vascular and Endocrine Surgery, University Hospital Halle (Saale), Germany
Giovanni Marchegiani, MD, PhD; Hepato Biliary Pancreatic (HPB) and Liver Transplant Surgery, Padova University Hospital, Italy
Tom Gallagher, MD; General Surgery / HPB and Liver Transplant Surgery, St Vincent's Private Hospital, Dublin, Ireland
Participating Centers:
Acibadem University, Istanbul, Turkey
Bologna University Hospital, Italy
Bonn University, Germany
Göttingen University, Germany
Halle (Saale) University, Germany
Liverpool University Hospitals NHS Foundation Trust, UK
Padova University Hospital, Italy
Peking Union Medical College Hospital, China
St Vincent's University Hospital, Dublin, Ireland
Funding:
Advanced Clinician Scientist Program, Faculty of Medicine, Martin-Luther-University Halle-Wittenberg
Authorship And Publication Policy
Centers contributing at least 10 cases qualify for authorship. Those with 50 cases or more may have two authorship positions. Study coordinators and principal investigators acknowledged as senior authors. Dissemination involves all authors; each center retains ownership of its data.
For additional information, please download the study protocol and register at REDCap®. For any other question, please contact us via email.
