Bernegger S, Brunner C, Vizovišek M, Fonovic M, Cuciniello G, Giordano F, Stanojlovic V, Jarzab M, Simister P, Feller SM, Obermeyer G, Posselt G, Turk B, Cabrele C, Schneider G, Wessler S (2020) A novel FRET peptide assay reveals efficient Helicobacter pylori HtrA inhibition through zinc and copper binding. Scientific Reports, 10: 10563

Bongartz H, Gille K, Hessenkemper W, Mandel K, Lewitzky M, Feller SM, Schaper F (2019) The multi-site docking protein Grb2-associated binder 1 (Gab1) enhances interleukin-6-induced MAPK-pathway activation in an SHP2-, Grb2-, and time-dependent manner. Cell Communication and Signaling, 17: 135.

Bongartz H, Hessenkemper W, Müller C, Fensky M, Fritsch J, Mandel K, Behrmann I, Haan C, Fischer T, Feller SM, Schaper F (2017) The multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617F-positive cells and mediates proliferation of human erythroleukaemia cells. CELLULAR SIGNALLING, 35: 37-47.

Frejno M, Zenezini Chiozzi R, Wilhelm M, Koch H, Zheng R, Klaeger S, Ruprecht B, Meng C, Kramer K, Jarzab A, Heinzlmeir S, Johnstone E, Domingo E, Kerr D, Jesinghaus M, Slotta-Huspenina J, Weichert W, Knapp S, Feller SM, Kuster B (2017) Pharmacoproteomic characterisation of human colon and rectal cancer. Molecular Systems Biology, 13: 951.

Feller SM, Lewitzky M (2016) Hunting for the ultimate liquid cancer biopsy - let the TEP dance begin. Cell Communication and Signaling, 14: 24.

Huang F, Ma Z, Pollan S, Yuan X, Swartwood S, Gertych A, Rodriguez M, Mallick J, Bhele S, Guindi M, Dhall D, Walts AE, Bose S, de Peralta Venturina M, Marchevsky AM, Luthringer DJ, Feller SM, Berman B, Freeman MR, Alvord WG, Vande Woude G, Amin MB, Knudsen BS (2016) Quantitative imaging for development of companion diagnostics to drugs targeting HGF/MET. J Pathol Clin Res, 2: 210-222.

Kramer HB, Lai CF, Patel H, Periyasamy M, Lin ML, Feller SM, Fuller-Pace FV, Meek DW, Ali S, Buluwela L (2016) LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner. NUCLEIC ACIDS RESEARCH, 44: 582-94.

Paster W, Bruger AM, Katsch K, Grégoire C, Roncagalli R, Fu G, Gascoigne NRJ, Nika K, Cohnen A, Feller SM, Simister PC, Molder KC, Cordoba SP, Dushek O, Malissen B, Acuto O (2015) A THEMIS:SHP1 complex promotes T-cell survival. EMBO JOURNAL, 34: 393-409.

Rouka E, Simister PC, Janning M, Kumbrink J, Konstantinou T, Muniz JRC, Joshi D, O'Reilly N, Volkmer R, Ritter B, Knapp S, von Delft F, Kirsch KH, Feller SM (2015) Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3). JOURNAL OF BIOLOGICAL CHEMISTRY, 290: 25275-92.

Stoepker C, Ameziane N, van der Lelij P, Kooi IE, Oostra AB, Rooimans MA, van Mil SE, Brink A, Dietrich R, Balk JA, Ylstra B, Joenje H, Feller SM, Brakenhoff RH (2015) Defects in the Fanconi Anemia Pathway and Chromatid Cohesion in Head and Neck Cancer. CANCER RESEARCH, 75: 3543-53.

Wolf A, Eulenfeld R, Bongartz H, Hessenkemper W, Simister PC, Lievens S, Tavernier J, Feller SM, Schaper F (2015) MAPK-induced Gab1 translocation to the plasma membrane depends on a regulated intramolecular switch. CELLULAR SIGNALLING, 27: 340-52.

Gao S, Bajrami I, Verrill C, Kigozi A, Ouaret D, Aleksic T, Asher R, Han C, Allen P, Bailey D, Feller S, Kashima T, Athanasou N, Blay JY, Schmitz S, Machiels JP, Upile N, Jones TM, Thalmann G, Ashraf SQ, Wilding JL, Bodmer WF, Middleton MR, Ashworth A, Lord CJ, Macaulay VM (2014) Dsh homolog DVL3 mediates resistance to IGFIR inhibition by regulating IGF-RAS signaling. CANCER RESEARCH, 74: 5866-77.

Krieger JM, Fusco G, Lewitzky M, Simister PC, Marchant J, Camilloni C, Feller SM, De Simone A (2014) Conformational recognition of an intrinsically disordered protein. BIOPHYSICAL JOURNAL, 106: 1771-9.

Lourenço FC, Munro J, Brown J, Cordero J, Stefanatos R, Strathdee K, Orange C, Feller SM, Sansom OJ, Vidal M, Murray GI, Olson MF (2014) Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferation. GUT, 63: 480-93.

Perna AM, Reisen F, Schmidt TP, Geppert T, Pillong M, Weisel M, Hoy B, Simister Philip C, Feller SM, Wessler S, Schneider G (2014) Inhibiting Helicobacter pylori HtrA protease by addressing a computationally predicted allosteric ligand binding site. Chemical Science, 5: 3583-3690.

Feller SM (2013) Tony (Anthony James) Pawson, a giant in the field of cell signaling research, dies unexpectedly at the age of 60. Cell Communication and Signaling, 11: 61.

Feller SM (2013) Excellence in cell signaling research recognized with major new award. Cell Communication and Signaling, 11: 17.

Paster W, Brockmeyer C, Fu G, Simister PC, de Wet B, Martinez-Riaño A, Hoerter JAH, Feller SM, Wülfing C, Gascoigne NRJ, Acuto O (2013) GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development. JOURNAL OF IMMUNOLOGY, 190: 3749-56.

Rose HM, Stuiver M, Thongwichian R, Theillet FX, Feller SM, Selenko P (2013) Quantitative NMR analysis of Erk activity and inhibition by U0126 in a panel of patient-derived colorectal cancer cell lines. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1834: 1396-401.

Sato S, Zhao Y, Imai M, Simister PC, Feller SM, Trackman PC, Kirsch KH, Sonenshein GE (2013) Inhibition of CIN85-mediated invasion by a novel SH3 domain binding motif in the lysyl oxidase propeptide. PLoS One, 8: e77288.

Simister PC, Luccarelli J, Thompson S, Appella DH, Feller SM, Hamilton AD (2013) Novel inhibitors of a Grb2 SH3C domain interaction identified by a virtual screen. BIOORGANIC & MEDICINAL CHEMISTRY, 21: 4027-33.

Tordella L, Koch S, Salter V, Pagotto A, Doondeea JB, Feller SM, Ratnayaka I, Zhong S, Goldin RD, Lozano G, McKeon FD, Tavassoli M, Fritzsche F, Huber GF, Rössle M, Moch H, Lu X (2013) ASPP2 suppresses squamous cell carcinoma via RelA/p65-mediated repression of p63. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110: 17969-74.

Feller S (2012) Microproteins (miPs) - the next big thing. Cell Communication and Signaling, 10: 42.

Feller SM (2012) Science, democracy and emerging threats to scientific progress. Cell Communication and Signaling, 10: 24.

Feller SM, Lewitzky M (2012) What's in a loop? Cell Communication and Signaling, 10: 31.

Feller SM, Lewitzky M (2012) Very 'sticky' proteins - not too sticky after all? Cell Communication and Signaling, 10: 15.

Kaneko T, Joshi R, Feller SM, Li SS (2012) Phosphotyrosine recognition domains: the typical, the atypical and the versatile. Cell Communication and Signaling, 10: 32.

Lewitzky M, Simister PC, Feller SM (2012) Beyond 'furballs' and 'dumpling soups' - towards a molecular architecture of signaling complexes and networks. FEBS LETTERS, 586: 2740-50.

Schuh A, Becq J, Humphray S, Alexa A, Burns A, Clifford R, Feller SM, Grocock R, Henderson S, Khrebtukova I, Kingsbury Z, Luo S, McBride D, Murray L, Menju T, Timbs A, Ross M, Taylor J, Bentley D (2012) Monitoring chronic lymphocytic leukemia progression by whole genome sequencing reveals heterogeneous clonal evolution patterns. BLOOD, 120: 4191-6.

Simister PC, Feller SM (2012) Order and disorder in large multi-site docking proteins of the Gab family--implications for signalling complex formation and inhibitor design strategies. Molecular BioSystems, 8: 33-46.


Ehsanian R, Van Waes C, Feller SM (2011) Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers. Cell Communication and Signaling, 9: 13.

Feller SM (2011) First Honorary Medal of the Signal Transduction Society (STS) and 'CELL COMMUNICATION AND SIGNALING' awarded to Professor Anthony J. (Tony) Pawson. Cell Communication and Signaling, 9: 3.

Feller SM (2011) Science under the lamppost. Cell Communication and Signaling, 9: 21.

Liu F, Giubellino A, Simister PC, Qian W, Giano MC, Feller SM, Bottaro DP, Burke TR (2011) Application of ring-closing metathesis to Grb2 SH3 domain-binding peptides. BIOPOLYMERS, 96: 780-8.

Simister PC, Schaper F, O'Reilly N, McGowan S, Feller SM (2011) Self-organization and regulation of intrinsically disordered proteins with folded N-termini. PLOS BIOLOGY, 9: e1000591.

Wu Z, Doondeea JB, Gholami AM, Janning MC, Lemeer S, Kramer K, Eccles SA, Gollin SM, Grenman R, Walch A, Feller SM, Kuster B (2011) Quantitative chemical proteomics reveals new potential drug targets in head and neck cancer. MOLECULAR & CELLULAR PROTEOMICS, 10: M111.011635.


Ehsanian R, Brown M, Lu H, Yang XP, Pattatheyil A, Yan B, Duggal P, Chuang R, Doondeea J, Feller S, Sudol M, Chen Z, Van Waes C (2010) YAP dysregulation by phosphorylation or ΔNp63-mediated gene repression promotes proliferation, survival and migration in head and neck cancer subsets. ONCOGENE, 29: 6160-71.

Feller, Stephan M (2010) Beyond journal impact factors? Cell Communication and Signaling, 8: 4.

Feller, Stephan M (2010) Early beginnings - the emergence of complex signaling systems and cell-to-cell communication. Cell Communication and Signaling, 8: 16.

Feller, Stephan M (2010) The dawn of a new era in cell signalling research. Cell Communication and Signaling, 8: 7.

Feller, Stephan M (2010) Life v2.0 - Quo vadis Homo sapiens? Cell Communication and Signaling, 8: 9.

Kress TR, Raabe T, Feller SM (2010) High Erk activity suppresses expression of the cell cycle inhibitor p27Kip1 in colorectal cancer cells. Cell Communication and Signaling, 8: 1.

Kroczek C, Lang C, Brachs S, Grohmann M, Dütting S, Schweizer A, Nitschke L, Feller SM, Jäck HM, Mielenz D (2010) Swiprosin-1/EFhd2 controls B cell receptor signaling through the assembly of the B cell receptor, Syk, and phospholipase C gamma2 in membrane rafts. JOURNAL OF IMMUNOLOGY, 184: 3665-76.

Pietrek M, Brinkmann MM, Glowacka I, Enlund A, Hävemeier A, Dittrich-Breiholz O, Kracht M, Lewitzky M, Saksela K, Feller SM, Schulz TF (2010) Role of the Kaposi's sarcoma-associated herpesvirus K15 SH3 binding site in inflammatory signaling and B-cell activation. JOURNAL OF VIROLOGY, 84: 8231-40.

Brady SC, Coleman ML, Munro J, Feller SM, Morrice NA, Olson MF (2009) Sprouty2 association with B-Raf is regulated by phosphorylation and kinase conformation. CANCER RESEARCH, 69: 6773-81.

Entschladen F, Lindquist JA, Serfling E, Thiel G, Kieser A, Giehl K, Ehrhardt C, Feller SM, Ullrich O, Schaper F, Janssen O, Hass R, Friedrich K (2009) Signal transduction--receptors, mediators, and genes. Science Signaling, 2: mr3.

Feller, Stephan M (2009) Obituary: hidesaburo hanafusa 1929-2009. Cell Communication and Signaling, 7: 7.

Friedrich K, Lindquist JA, Entschladen F, Serfling E, Thiel G, Kieser A, Giehl K, Ehrhardt C, Feller SM, Ullrich O, Schaper F, Janssen O, Hass R (2009) Signal transduction in the footsteps of goethe and schiller. Cell Communication and Signaling, 7: 2.

Harkiolaki M, Tsirka T, Lewitzky M, Simister PC, Joshi D, Bird LE, Jones EY, O'Reilly N, Feller SM (2009) Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. STRUCTURE, 17: 809-22.

Watanabe T, Tsuda M, Makino Y, Konstantinou T, Nishihara H, Majima T, Minami A, Feller SM, Tanaka S (2009) Crk adaptor protein-induced phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration. CELL RESEARCH, 19: 638-50.

Aleksic T, Feller SM (2008) Gamma-secretase inhibition combined with platinum compounds enhances cell death in a large subset of colorectal cancer cells. Cell Communication and Signaling, 6: 8.

Backert S, Feller SM, Wessler S (2008) Emerging roles of Abl family tyrosine kinases in microbial pathogenesis. TRENDS IN BIOCHEMICAL SCIENCES, 33: 80-90.

Benz PM, Blume C, Moebius J, Oschatz C, Schuh K, Sickmann A, Walter U, Feller SM, Renné T (2008) Cytoskeleton assembly at endothelial cell-cell contacts is regulated by alphaII-spectrin-VASP complexes. JOURNAL OF CELL BIOLOGY, 180: 205-19.

Benz PM, Feller SM, Sickmann A, Walter U, Renné T (2008) Prostaglandin-induced VASP phosphorylation controls alpha II-spectrin breakdown in apoptotic cells. INTERNATIONAL IMMUNOPHARMACOLOGY, 8: 319-24.

Emaduddin M, Bicknell DC, Bodmer WF, Feller SM (2008) Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105: 2358-62.

Emaduddin M, Edelmann MJ, Kessler BM, Feller SM (2008) Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells. Cell Communication and Signaling, 6: 7

Feller SM, Hass R, Janssen O, Friedrich K (2008) Cell Communication and Signaling is becoming the official journal of the Signal Transduction Society. Cell Communication and Signaling, 6: 1.

Niendorf S, Oksche A, Kisser A, Löhler J, Prinz M, Schorle H, Feller S, Lewitzky M, Horak I, Knobeloch KP (2007) Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivo. MOLECULAR AND CELLULAR BIOLOGY, 27: 5029-39.

Poppe M, Feller SM, Römer G, Wessler S (2007) Phosphorylation of Helicobacter pylori CagA by c-Abl leads to cell motility. ONCOGENE, 26: 3462-72.

Cadd VA, Hogg PJ, Harris AL, Feller SM (2006) Molecular profiling of signalling proteins for effects induced by the anti-cancer compound GSAO with 400 antibodies. BMC CANCER, 6: 155.

Feller SM, Lewitzky M (2006) Potential disease targets for drugs that disrupt protein-- protein interactions of Grb2 and Crk family adaptors. CURRENT PHARMACEUTICAL DESIGN, 12: 529-48.

Harkiolaki M, Gilbert RJC, Jones EY, Feller SM (2006) The C-terminal SH3 domain of CRKL as a dynamic dimerization module transiently exposing a nuclear export signal. STRUCTURE, 14: 1741-53.


Hogan C, Serpente N, Cogram P, Hosking CR, Bialucha CU, Feller SM, Braga VMM, Birchmeier W, Fujita Y (2004) Rap1 regulates the formation of E-cadherin-based cell-cell contacts. MOLECULAR AND CELLULAR BIOLOGY, 24: 6690-700.

Lewitzky M, Harkiolaki M, Domart MC, Jones EY, Feller SM (2004) Mona/Gads SH3C binding to hematopoietic progenitor kinase 1 (HPK1) combines an atypical SH3 binding motif, R/KXXK, with a classical PXXP motif embedded in a polyproline type II (PPII) helix. JOURNAL OF BIOLOGICAL CHEMISTRY, 279: 28724-32.

Schmidt EK, Fichelson S, Feller SM (2004) PI3 kinase is important for Ras, MEK and Erk activation of Epo-stimulated human erythroid progenitors. BMC BIOLOGY, 2: 7.


Feller SM, Tuchscherer G, Voss J (2003) High affinity molecules disrupting GRB2 protein complexes as a therapeutic strategy for chronic myelogenous leukaemia. LEUKEMIA & LYMPHOMA, 44: 411-27.

Harkiolaki M, Lewitzky M, Gilbert RJC, Jones EY, Bourette RP, Mouchiroud G, Sondermann H, Moarefi I, Feller SM (2003) Structural basis for SH3 domain-mediated high-affinity binding between Mona/Gads and SLP-76. EMBO JOURNAL, 22: 2571-82.

Feller SM, Wecklein H, Lewitzky M, Kibler E, Raabe T (2002) SH3 domain-mediated binding of the Drk protein to Dos is an important step in signaling of Drosophila receptor tyrosine kinases. MECHANISMS OF DEVELOPMENT, 116: 129-39.

Schweimer K, Hoffmann S, Bauer F, Friedrich U, Kardinal C, Feller SM, Biesinger B, Sticht H (2002) Structural investigation of the binding of a herpesviral protein to the SH3 domain of tyrosine kinase Lck. BIOCHEMISTRY, 41: 5120-30.

Feller SM (2001) Crk family adaptors-signalling complex formation and biological roles. ONCOGENE, 20: 6348-71.

Lewitzky M, Kardinal C, Gehring NH, Schmidt EK, Konkol B, Eulitz M, Birchmeier W, Schaeper U, Feller SM (2001) The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif. ONCOGENE, 20: 1052-62.

Sabbak D, Kardinal C, Lewtitzky M, Walburg M, Knudsen BS, Feller SM (2001) Hepatocyte growth factor/scaffer (HGF) signaling depends on Crk family adapter proteins. Signal Transduction, 1: 25-36.

Voss J, Heisterkamp N, Groffen J, Feller SM (2001) Leukemic Kinases of the Abl family - an update. Signal Transduction, 1: 1-26.

Wenzel J, Sanzenbacher R, Ghadimi M, Lewitzky M, Zhou Q, Kaplan DR, Kabelitz D, Feller SM, Janssen O (2001) Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor. FEBS LETTERS, 509: 255-62.

Coutinho S, Jahn T, Lewitzky M, Feller S, Hutzler P, Peschel C, Duyster J (2000) Characterization of Ggrb4, an adapter protein interacting with Bcr-Abl. BLOOD, 96: 618-24.

Luber B, Candidus S, Handschuh G, Mentele E, Hutzler P, Feller S, Voss J, Höfler H, Becker KF (2000) Tumor-derived mutated E-cadherin influences beta-catenin localization and increases susceptibility to actin cytoskeletal changes induced by pervanadate. CELL COMMUNICATION AND ADHESION, 7: 391-408.

Posern G, Rapp UR, Feller SM (2000) The Crk signaling pathway contributes to the bombesin-induced activation of the small GTPase Rap1 in Swiss 3T3 cells. ONCOGENE, 19: 6361-8.

Posern G, Saffrich R, Ansorge W, Feller SM (2000) Rapid lamellipodia formation in nerve growth factor-stimulated PC12 cells is dependent on Rac and PI3K activity. JOURNAL OF CELLULAR PHYSIOLOGY, 183: 416-24.

Sakkab D, Lewitzky M, Posern G, Schaeper U, Sachs M, Birchmeier W, Feller SM (2000) Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL. JOURNAL OF BIOLOGICAL CHEMISTRY, 275: 10772-8.

Schmidt M, Goebeler M, Posern G, Feller SM, Seitz CS, Brocker EB, Rapp UR, Ludwig S (2000) Ras-independent activation of the Raf/MEK/ERK pathway upon calcium-induced differentiation of keratinocytes. JOURNAL OF BIOLOGICAL CHEMISTRY, 275: 41011-7.

Schulz A, Aderman K, Eulitz M, Feller SM, Kardinal C (2000) Preparation of disulfide-bonded heterodimers by tiration of thioactivated peptides with thiol-containing peptides. Tetrahedron, 56: 3889-3891.